Zoonoses are primarily recognized as animal diseases that are transmitted to human beings through various routes. These diseases have a serious impact on public health as well as economy throughout the world. Leptospirosis is an emerging and re-emerging infectious zoonotic disease with global public health implications in terms of morbidity and mortality of humans and livestock. The disease can occur in sporadic as well as in epidemic forms. The source of infection is exogenous. Leptospirosis is a life threatening disease that causes 10.3 million cases and 58900 deaths each year worldwide. Rodents are considered the main reservoir of Leptospira. The contact of the skin with moist soil, water, and vegetation contaminated with urine of the infected animals and penetration of the organism to the skin, mucous membrane through abrasion, cut, and injury help in the transmission of the infection. Leptospirosis presents most important public health crisis that exists at the animals-humans-ecosystem interface. A strategic break in the relationship between the host-pathogen and their ecosystem could provide effective control of several possible zoonoses including leptospirosis. Global strategy to broaden interdisciplinary partnerships and coordination in all areas of health care for humans, livestock and the community is required.