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2014, Neuro-Oncology
Pharmacological Research
IN VIVO GLIOMA GROWTH REQUIRES HOST-DERIVED MATRIX METALLOPROTEINASE 2 FOR MAINTENANCE OF ANGIOARCHITECTURE2002 •
2002 •
2002 •
Membrane-type (MT) 1 matrix metalloproteinase (MMP) is up-regulated in many tumor types and has been implicated in tumor progression and metastasis. MT1-MMP is critical for pericellular degradation of the extracellular matrix, thereby promoting tumor cell invasion and dissemination. To grow efficiently in vivo, tumor cells induce angiogenesis in both primary solid tumors and metastatic foci. The present study describes a functional link between the expression of MT1-MMP and vascular endothelial growth factor (VEGF) production in human glioma U251 xenografts in athymic mice. To investigate the effects of MT1-MMP on VEGF expression, U251 cells were stably transfected with MT1-MMP to generate the U-MT cell line overexpressing the enzyme. In vitro, the U-MT cells had an increased rate of proliferation and migration as well as the ability to activate the MMP-2 proenzyme and directionally remodel a three-dimensional collagen matrix. These findings suggested higher tumorigenicity of U-MT c...
Clinical & experimental metastasis
Modulation of endothelial cell morphogenesis in vitro by MMP-9 during glial-endothelial cell interactions2000 •
The purpose of this study was to investigate the roles of matrix metalloproteinase-9 (MMP-9) and tissue inhibitor of metalloproteinase-1 (TIMP-1) in the formation of capillary structures by human brain microvascular endothelial cells cocultured with SNB19 glioblastoma cells. Unstimulated cocultures did not form capillaries and produce MMP-9 but stimulation with the protein kinase C (PKC) activator 4-phorbol-12-myristate 13-acetate (PMA) produced MMP-9 and capillary networks. Addition of recombinant MMP-9 increased capillary formation. Anti-MMP-9 antibodies, TIMP-1, the synthetic MMPs inhibitor Batimastat (BB-94), and the PKC inhibitor calphostin-C all reduced MMP-9 activity and capillary network formation in these cocultures. Cytochalasin-D in the presence of PMA suppressed MMP-9 expression and capillary formation, but colchicine-B had no such effect. Finally, PMA-induced MMP-9 expression and capillary formation were inhibited by the MEKK-specific inhibitor PD98059. These results su...
Cancer Research
Tumor MMP-1 Activates Endothelial PAR1 to Facilitate Vascular Intravasation and Metastatic Dissemination2013 •
International journal of clinical and experimental pathology
Expression of MMP-2 correlates with increased angiogenesis in CNS metastasis of lung carcinoma2010 •
Matrix metalloproteinases (MMP) have been implicated in increased invasive and metastatic potential of tumors, possibly via interactions with the extracellular matrix and angiogenesis. This study investigates the relationship between MMP-2 immunoexpression and angiogenesis in a series of lung carcinomas metastatic to the central nervous system (CNS). Twenty eight metastatic carcinoma cases with adequate brain-tumor interface were identified from the archives at the Moffitt Cancer Center. MMP-2 expression was determined by immunohistochemistry using an antibody directed against pro and active forms (NeoMarkers). Similarly, microvessels were identified on parallel sections with anti-CD34 antibody (Biogenix). Angiogenesis profiles within the tumor and at the CNS/tumor interface were morphometrically assessed by the Image Pro Plus image analysis system. Briefly, CD34 positive vessels were quantitated and correlated with presence or absence of MMP-2 expression in the tumor. Mean microves...
The American Journal of Pathology
Matrix Metalloproteinase-1 and Thrombin Differentially Activate Gene Expression in Endothelial Cells via PAR-1 and Promote Angiogenesis2008 •
Anticancer Research
Glioblastoma Factors Increase the Migration of Human Brain Endothelial Cells In Vitro by Increasing MMP-9/CXCR4 Levels… journal of oncology
Glioma cells suppress hypoxia-induced endothelial cell apoptosis and promote angiogenic process2007 •
2001 •
Angiogenesis, tumor cell proliferation, and migration are the hallmarks of solid tumors, such as gliomas. This study demonstrates that a fragment derived from the autocatalytic digestion of matrix metalloproteinase (MMP)-2, called PEX, acts simultaneously as an inhibitor of glioma angiogenesis, cell proliferation, and migration. PEX is detected in the cultured medium of various human glioma, endothelial, breast, and prostate carcinoma cell lines. PEX is purified from the medium of glioma cell lines by chromatography, where PEX is constitutively expressed as a free and a TIMP-2-bound form. In human glioma tissue, PEX expression correlates with histological subtype and grade and with alpha v beta 3 integrin expression to which it is bound. Systemic administration of PEX to s.c. and intracranial human glioma xenografts results in a 99% suppression of tumor growth with no signs of toxicity. Thus, PEX is a very promising candidate for the treatment of human malignant gliomas.
Studies on Tantra in Bengal and Eastern India
Prema and Śakti: Vaiṣṇava Sahajiyā Appropriations of Gauḍīya Vaiṣṇavism and Śāktism in the Ānandabhairava of Prema-dāsa2022 •
Psychology & Sexuality
LGBTQ+ emerging adults perceptions of discrimination and exclusion within the LGBTQ+ community2020 •
Revista de História
Da Paraíba ao Estado do Maranhão: trajetórias de governo na américa portuguesa (séculos XVII e XVIII)2009 •
Anales de la Facultad de Medicina
Efectos de la Irradiación Gamma en Ratones2014 •
Jurnal Studi Komunikasi (Indonesian Journal of Communications Studies)
The impact of public information awareness and service towards public engagementEnvironmental Microbiology
Comparative genomics and physiology of the genus Methanohalophilus , a prevalent methanogen in hydraulically fractured shale2018 •
European Physical Journal C
Greybody factors of holographic superconductors with $$z=2$$ Lifshitz scaling2020 •
Colloids and Surfaces A: Physicochemical and Engineering Aspects
Hybrid hydrogel systems of micelles of drug anion containing ionic liquid and biopolymers: Rheological behavior and drug release2018 •
European Psychiatry
The impact of interpersonal violence in youth sport on adult psychopathology2017 •
SWOT Analysis in Business Risk Awareness in MSMEs
SWOT Analysis in Business Risk Awareness in MSMEs2024 •