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2017, Journal of Nursing and Health Studies
Annals of Pharmacotherapy
Serious Psychiatric Symptoms After Chloroquine Treatment Following Experimental Malaria Infection2005 •
OBJECTIVE: To report serious psychiatric symptoms after standard chloroquine treatment following human malaria infection induced for research. CASE SUMMARY: A 34-year-old healthy woman volunteered to participate in a study of malaria treatment. She was infected on day 0 with a chloroquine-susceptible strain of Plasmodium falciparum and was treated with a standard 3-day course of chloroquine from day 9 onward, following a positive blood smear (parasitemia 0.001%). On day 10, the blood smear became negative. On day 11, she developed a psychotic disorder not otherwise specified, most probably caused by chloroquine use, with symptoms of depersonalization and anxiety. The diagnosis of delirium was considered but ruled out because of clear consciousness with lack of diurnal fluctuations. She refused to take antipsychotic medication. Three weeks later, the woman still encountered serious concentration problems. All complaints gradually subsided over the next 4 months, after which she felt ...
Travel Medicine and Infectious Disease
Antimalarial chemoprophylaxis and the risk of neuropsychiatric disorders2013 •
Chloroquine and hydroxychloroquine are commonly used drugs in the treatment of malaria as well as chronic diseases, such as rheumatoid arthritis, and systemic lupus erythematosus. Although various reports on possible psychiatric side effects of these drugs exist, the nature and extent of these effects remain poorly understood. Moreover, the relevance of these drugs in the treatment of early stages of COVID-19 necessitates a careful estimation of their side effects. Here, we provide a systematic review of the psychiatric side effects associated with chloroquine and hydroxychloroquine. We used PubMed, Scopus, and Web of Science platforms to identify relevant literature published between 1962 and 2020. Search terms included chloroquine, hydroxychloroquine, psychiatry, psychosis, depression, anxiety, bipolar disorder, delirium, and psychotic disorders. Only case reports and clinical trials were included. All studies included records of psychiatric side effects induced by either chloroqu...
Open Journal of Preventive Medicine
Review: Can Toxic Substances Initiate Psychotic Behavior? Part I. Antimalarial Drugs2014 •
Clinical Case Reports
Prolonged neuropsychiatric effects following management of chloroquine intoxication with psychotropic polypharmacy2015 •
Drug, Healthcare and …
Signal detection to identify serious adverse events (neuropsychiatric events) in travelers taking mefloquine for chemoprophylaxis of malaria2012 •
BackgroundFor all medications, there is a trade-off between benefits and potential for harm. It is important for patient safety to detect drug-event combinations and analyze by appropriate statistical methods. Mefloquine is used as chemoprophylaxis for travelers going to regions with known chloroquine-resistant Plasmodium falciparum malaria. As such, there is a concern about serious adverse events associated with mefloquine chemoprophylaxis. The objective of the present study was to assess whether any signal would be detected for the serious adverse events of mefloquine, based on data in clinicoepidemiological studies.Materials and methodsWe extracted data on adverse events related to mefloquine chemoprophylaxis from the two published datasets. Disproportionality reporting of adverse events such as neuropsychiatric events and other adverse events was presented in the 2 × 2 contingency table. Reporting odds ratio and corresponding 95% confidence interval [CI] data-mining algorithm was applied for the signal detection. The safety signals are considered significant when the ROR estimates and the lower limits of the corresponding 95% CI are ≥2.ResultsTwo datasets addressing adverse events of mefloquine chemoprophylaxis (one from a published article and one from a Cochrane systematic review) were included for analyses. Reporting odds ratio 1.58, 95% CI: 1.49–1.68 based on published data in the selected article, and 1.195, 95% CI: 0.94–1.44 based on data in the selected Cochrane review. Overall, in both datasets, the reporting odds ratio values of lower 95% CI were less than 2.ConclusionBased on available data, findings suggested that signals for serious adverse events pertinent to neuropsychiatric event were not detected for mefloquine. Further studies are needed to substantiate this.
Malaria Journal
Neurological and psychiatric safety of tafenoquine in Plasmodium vivax relapse prevention: a reviewBackground Tafenoquine is an 8-aminoquinoline anti-malarial drug recently approved as a single-dose (300 mg) therapy for Plasmodium vivax relapse prevention, when co-administered with 3-days of chloroquine or other blood schizonticide. Tafenoquine 200 mg weekly after a loading dose is also approved as travellers’ prophylaxis. The development of tafenoquine has been conducted over many years, using various dosing regimens in diverse populations. Methods This review brings together all the preclinical and clinical data concerning tafenoquine central nervous system safety. Data were assembled from published sources. The risk of neuropsychiatric adverse events (NPAEs) with single-dose tafenoquine (300 mg) in combination with chloroquine to achieve P. vivax relapse prevention is particularly examined. Results There was no evidence of neurotoxicity with tafenoquine in preclinical animal models. In clinical studies in P. vivax relapse prevention, nervous system adverse events, mainly heada...
Sultan Qaboos University Medical Journal
Chloroquine-induced Acute Dystonic Reactions after a Standard Therapeutic Dose for Uncomplicated Malaria2013 •
Journal of Kathmandu Medical College
A study on mefloquine-associated neuropsychiatric manifestations among Nepalese soldiers posted for United Nations peace mission2018 •
Background: Mefloquine is one of the prophylactic medications recommended by the government of Nepal. In areas of intense malaria transmission, prophylaxis with drugs is an important strategy to prevent malaria. During prophylactic use, several neuro-psychiatric and other systemic adverse effects can occur with mefloquine. Notable psychiatric manifestations include anxiety, depression, restlessness, and confusion. Objective: To study the psychiatric effects of mefloquine in Nepalese serving soldiers posted in the United Nations peace mission nations of the African continent taking mefloquine prophylaxis. Methodology: This prospective descriptive study was conducted among Nepalese soldiers posted for United Nations peace mission in South Sudan over a period of one year. Soldiers of age group 25-55 years posted for peace mission having no past and family history of psychiatric illnesses were enrolled in the study. General Health Questionnaire-12, translated into Nepali by Nepalese Jou...
2024 •
Biblische Notizen
Die "Mutter alles Lebendigen" auf den ältesten Bildzeugnissen der Levante und im Genesis-Prolog: Biblische Notizen 187, 2020, 3-14.2020 •
Calculated Nationalism in Contemporary South Korea
Calculated Nationalism in Contemporary South Korea"Standing on the shoulders of giants": A Festschrift in honour of Wolfgang Mieder on the occasion of his 80th birthday
LEARNING FROM "WRONG" ANSWERS IN PROVERB SURVEYS2020 •
Balanced Automation Systems II
Measuring manufacturing flexibility a resource-elements based approach1996 •
Conflict Management and Peace Science
Geographic Proximity, Trade, and International Conflict/Cooperation2007 •
Asia-Pacific Science Education
A Teacher’s Practical Knowledge in an SSI-STEAM Program Dealing with Climate ChangeJournal of Hypertension
Smokeless Tobacco (Snus) and Risk of Heart Failure in Two Swedish Cohorts: PP.1.062010 •
International Journal of Bifurcation and Chaos
Controlling Chaotic Dynamics Using Backstepping Design with Application to the Lorenz System and Chua's Circuit1999 •
International Journal of Fauna and Biological Studies
Effect of broad range doses of oral administration of Zinc Oxide Nanoparticles in freshwater fish Oreochromis mossambicus2019 •
2016 •
BioMed Research International
Leishmania infantum Genetic Diversity and Lutzomyia longipalpis Mitochondrial Haplotypes in Brazil2016 •