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2017, Clinical Therapeutics
2000 •
American Journal of Hypertension
Effect of Antihypertensive Treatment on Cardiac and Subcutaneous Artery Structure A Comparison Between Calcium Channel Blocker and Thiazide-Based Regimens1998 •
2019 •
Introduction: Hypertension is significantly contributing to global mortality and morbidity and has been identified as the most important modifiable risk factor for early development of cardio-vascular diseases (CVD). Aim: The aim of this study was to investigate the efficacy of different combinations of antihypertensive therapy on blood pressure, arterial stiffness and peripheral resistance in patients with essential hypertension using the brachial oscillometric ambulatory blood pressure monitor. Methods: This study was designed as an observational, prospective, multi centric study conducted in eight primary care centers of the Health Center of Canton Sarajevo during the period of six months. The study included 655 participants, both genders, aged between 30 and 75, who were diagnosed with hypertension according to the ESC/ESH guidelines. Participants were divided into six treatment groups based on the hypertensive drug therapy they were using; lisinopril, losartan or valsartan alone or in combination with hydrochlorothiazide (A, B and C group respectively) or combination of lisinopril, losartan or valsartan with/without hydrochlorothiazide together with amlodipine (D, E and F respectively). The participants were monitored at baseline, after 3 and 6 months (1 st and 2 nd follow-up). Brachial oscillometric ambulatory blood pressure monitor was used for measuring systolic (SBP), diastolic (DBP), pulse pressure (PP), pulse wave velocity (PWV) and peripheral resistance (PR). Results: SBP, DPB, PP, and PWV significantly decreased from baseline to 2 nd follow-up in all treatment groups. The mean reductions in SBP were from-11.7 (95%CI; 9.3-14.1) to-23.2 (95%CI; 18.3-28.1) mmHg and DBP reductions varied from-5.5 (95%CI; 3.9-7.1) to-13.4 (95%CI; 7.7-19.1) mmHg. PWV decreased in all treatment groups (from-3.3% to-8.2%). Treatment regiment was not associated with significant differences in SBP, DBP, PP or PWV reductions or their values measured at 2 nd follow-up. Peripheral resistance significantly decreased only in group C (p=0.011), group D (p=0.009) and group F (p=0.027). Conclusion: These data suggest that lisinopril/lisinopril + hydrochlorothiazide, losartan/losartan + hydrochlorothiazide and valsartan/valsartan + hydrochlorothiazide alone or in combination with amlodipine are equally effective and well tolerated for the reduction of both systolic and diastolic blood pressure and improve arterial stiffness in patients with essential hypertension.
2009 •
Journal of Human Hypertension
Differential pulse pressure response to various antihypertensive drug families2006 •
Current Therapeutic Research
Blood pressure profile as a predictor of reversal of cardiovascular structural changes during antihypertensive treatment1997 •
2014 •
2023 •
Routledge Readings in Colonial and Contemporary Northeastern India
Practices of Sovereignty, Practices of the Market and Early Colonialism2024 •
2016 •
… de Arte: Revista del Departamento de …
La fototeca del Laboratorio de arte1995 •
2015 •
Prostate Cancer and Prostatic Diseases
Obese men have more advanced and more aggressive prostate cancer at time of surgery than non-obese men after adjusting for screening PSA level and age: results from two independent nested case–control studies2013 •
European Journal of Science and Theology
ABBREVIATIONS AND SYMBOLS FOUNDED IN BIBLICAL MANUSCRIPTS AND CHRISTIANS ICONS2010 •
2018 •
Revista Digital Universitaria
Habilidades del futuro para los estudiantes del SUAyEDJournal of the American Society for Mass Spectrometry
Ter-body intermediates in the gas phase: Reaction of ionized enols with tert-butanol2001 •
Revista Argentina de Cardiología
Efficacy of Multielectrode Array Catheter for Ventricular Tachycardia Ablation in a Patient with Electrical Storm2015 •