McNair Poster Presentations McNair Scholars Institute 2014 Ambulatory Extracorporeal Arterioveous CO2 Removal via Subclavian Vessels Alejandra Macias University of Nevada, Las Vegas Alvaro Rojas-Pena University of Michigan - Ann Arbor Follow this and additional works at: https://digitalscholarship.unlv.edu/mcnair_posters Part of the Biomechanical Engineering Commons, and the Medicine and Health Sciences Commons Repository Citation Macias, A., Rojas-Pena, A. (2014). Ambulatory Extracorporeal Arterioveous CO2 Removal via Subclavian Vessels. Available at: https://digitalscholarship.unlv.edu/mcnair_posters/28 This Poster is protected by copyright and/or related rights. It has been brought to you by Digital Scholarship@UNLV with permission from the rights-holder(s). You are free to use this Poster in any way that is permitted by the copyright and related rights legislation that applies to your use. For other uses you need to obtain permission from the rights-holder(s) directly, unless additional rights are indicated by a Creative Commons license in the record and/ or on the work itself. This Poster has been accepted for inclusion in McNair Poster Presentations by an authorized administrator of Digital Scholarship@UNLV. For more information, please contact digitalscholarship@unlv.edu. Alejandra Macias, McNair Scholar, Mechanical Engineering Major! Dr. Alvaro Rojas-Peña, Faculty Mentor, Department of Surgery, University of Michigan Health Systems! Figure 2: Cannulas Figure 3: Novalung ® iLA Conclusions   ! ! The arteriovenous shunt was 13.39±3.8% (21.2±2.5 mL/min/kg) of cardiac output, yet systemic hemodynamics remained stable. Across the device, PaCO2 decreased on average from 28.6 to 19.3 mmHg in the healthy sheep, while in the hypercapnic animals it decreased from 59.4 to 36.2 mmHg. Device efficacy was further evidenced by the rising CO2 removal rate for both animal conditions as the sweep flow increased, achieving a maximum of 228.25 mL/min in the healthy animals and 202.5 mL/min in the hypercapnic ones. This demonstrates that the proposed configuration is not only feasible, but has the potential to be a bridge to lung transplantation and even a future destination therapy for hypercapnic patients. Methods  and  methods Following University of Michigan’s protocols, 4 healthy sheep (61±6.2 kg) were anesthetized. The left subclavian vessels were exposed surgically. Two vascular grafts were anastomosed to the artery and vein and subsequently cannulated (17Fr) to create an AV shunt. Each animal was extubated, recovered, and fitted with a low-resistance membrane gas exchanger. The device’s effectiveness at removing CO2 was measured by analyzing pre- and postdevice blood gases and sweep gas exhaust samples as room air sweep flow was incrementally raised from 0-15 L/min. This was done in awake, spontaneously breathing animals and repeated after they were re-anesthetized, placed on mechanical ventilation, and rendered hypercapnic by lowering minute ventilation to less than 2 L/min. Figure 1: Study Schematic Literature  Cited 2012 Annual Report of the U.S. Organ Procurement and Transplantation Network and the Scientific Registry of Transplant Recipients: Transplant Data 2012. Department of Health and Human Services, Health Resources and Services Administration, Healthcare Systems Bureau, Division of Transplantation, Rockville, MD; United Network for Organ Sharing, Richmond, VA; University Renal Research and Education Association, Ann Arbor, MI Acknowledgments   Authors of Pending Publication: Lucas Witer, MD; Ryan Howard, BA; Benjamin Bryner, MD; John Trahanas, MD; Fares Alghanem BS; Hayley Hoffman, BS; Alvaro Rojas-Peña, MD; Robert Bartlett, MD Cardiovascular Center Summer Undergraduate Research Fellowship & The Esperance Family Foundation Extracorporeal Life Support Laboratory team Director: Dr. Bartlett Research Fellows, Staff, and Students University of Michigan & University of Nevada, Las Vegas The Center for Academic Enrichment and Outreach, UNLV Ronald E. McNair Scholars Institute Further  informa9on   Extracorporeal Life Support Research Lab http://www.sitemaker.umich.edu/ecls/home