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2023, Mohammed Ahmed Bamashmos
New diabetic disease modified drugs
Diabetes Spectrum
New Drugs in Development for the Treatment of Diabetes2009 •
In Brief A variety of new agents are in development for the treatment of type 1 or type 2 diabetes. In addition to new dipeptidyl peptidase-4 inhibitors, glucagon-like peptide 1 analogs, thiazolidinediones, glinides, and new insulin formulations, there are also unique peroxisome proliferator-activated receptor agonists, selective sodium glucose cotransporter 2 inhibitors, and several other unique agents now in development.
2020 •
Diabetes mellitus is among the top 10 life threatening diseases across the globe. It can further cause fatal diseases like cardiovascular complications, atherosclerosis, nephropathy etc. This disease affects millions of people each year in both rural as well as urban areas. Currently, many anti-diabetic drugs are available commercially, but there are many problems or side effects that are related to those drugs like hyperglycemia or hypoglycemia. With the help of advance technology, new formulations are being produced or modifications are being performed on the existing drugs for better efficacy. This review mainly focuses on the current advancements in the anti-diabetic drugs.
2024 •
Elsharif Bazie, Ahmed Elkhalifa, Mehak Nazar, Iqra Hussain, Zahid Ramz, Shubeena Ahad, Nusr Bashir, Elham Elamin
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY
ABS TRACT Although diabetes mellitus (DM) is known to mankind since long and much is studied, written and practiced about this disease, but still we have not been able to conquer this devil. Instead it is expanding by monstrous proportions. As a result of years of research, many good drugs are available which essentially control the hyperglycemia. But as per our recent knowledge diabetes mellitus is much more than mere hyperglycemia. New clinical goals are being set to improve the patient outcome in diabetes, in relation to which new targets are identified which can help in achieving these clinical goals. M any new drugs are under development based on such targets, several of which may enter in the battery of standard drugs for DM in near future. In this article we take an overview of such drugs which are under development, clinical or preclinical.
2015 •
Diabetes type 2 is a metabolic condition diabetes is constantly increasing worldwide. Regardless of the integrated approach to the disease treatment, the proportion of patients with poor glycemic control remains high. New ph products with improved tolerability and efficacy are in the focus of continuous research and development efforts.
Background: Diabetes mellitus has reached epidemic proportions in many countries. Current challenges in diabetes mellitus management include: optimizing the use of currently available therapies to ensure adequate glycemic, blood pressure, and lipid control and to reduce complications. Aim of the review is to provide a brief overview of recent advancement in diabetes mellitus management. Method Different published articles were reviewed systematically. Result Current standard of care for Type 2 Diabetes mellitus consists of screening for elevated HbA1c levels or, in some cases, fasting plasma glucose, with diagnosis followed by management with lifestyle modifications and metformin. While Insulin, along with diet, is crucial to the survival of individuals with Type 1Diabetes Mellitus. Despite the known benefits of lifestyle modification, and insulin therapy many individuals still find it harder to maintain a healthier life because of the higher possibilities of sedentary behavior and overeating in the modern world. The success of antidiabetes medication has also been limited by their mechanisms of action, and undesirable side effects. The past 10 years have seen an explosion in the number of new treatments available for diabetes and there are a number of exciting new drugs in development to achieve these goals including oral insulin, islet and pancreatic cell transplant, gene therapy, the incretins, dipeptidyl peptidase-4 inhibitors, peroxisome proliferator-activated receptor inhibitors, and sodium–glucose cotransporter inhibitors to treat Type 2 diabetes Mellitus. Conclusion Current standard of care for diabetes management is not sufficient to provide long run benefits to diabetes patients. Therefore, future remedies with the modifications in insulin delivery system and pharmacogenetic therapeutic approaches could possibly provide the much nodded effect and changes the outcome of diabetes management with new outlook.
Journal of Diabetes Research
Recent Trends in Therapeutic Approaches for Diabetes Management: A Comprehensive Update2015 •
Diabetes highlights a growing epidemic imposing serious social economic crisis to the countries around the globe. Despite scientific breakthroughs, better healthcare facilities, and improved literacy rate, the disease continues to burden several sections, especially middle and low income countries. The present trends indicate the rise in premature death, posing a major threat to global development. Scientific and technological advances have witnessed the development of newer generation of drugs like sulphonylureas, biguanides, alpha glucosidase inhibitors, and thiazolidinediones with significant efficacy in reducing hyperglycemia. Recent approaches in drug discovery have contributed to the development of new class of therapeutics like Incretin mimetics, Amylin analogues, GIP analogs, Peroxisome proliferator activated receptors, and dipeptidyl peptidase-4 inhibitor as targets for potential drugs in diabetes treatment. Subsequently, the identification and clinical investigation of bio...
Diabetes Mellitus (DM) is a complex set of disease. It is basically a metabolic disorder in which body is unable to make enough insulin or it is not able to use insulin effectively or in some instances both. According to global report on diabetes released by World Health Organization, Geneva 422 million people suffers from diabetes in 2014. The number is expected to increase to 552 million by 2030. A number of researches are going on around the globe by pharmaceutical companies to exploit the huge market it provides. This short review covers the brief basics of DM and its classification medication. This review mainly focus on type 2 diabetes discussing the new classification of medication available in the market as well as the approved antidiabetic drugs for type 2 diabetes by USFDA after 2010 and the pipeline antidiabetic drugs under clinical trials.
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'Filosofía y religión en la Grecia antigua'. Dirigido por Jorge Luis Gutiérrez y David Torrijos-Castrillejo. Editado por Andre da Paz, Luiz Eduardo Freitas y Pedro Maurício Garcia Dotto, Salamanca: Pontificia Universidad de Salamanca/Sindéresis, 2024. ISBN: 978-84-17601-83-6, 291 pp.
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