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2010, Emerging infectious diseases
Because chemokine receptor 5 (CCR5) may have a role in pulmonary immune response, we explored whether patients with severe pandemic (H1N1) 2009 were more likely to carry the CCR5Δ32 allele than were members of the general population. We found a large proportion of heterozygosity for the CCR5Δ32 allele among white patients with severe disease.
2020 •
A polymorphism in the LZTFL1 gene located in the chemokine-receptor gene cluster (chromosome 3p) has been associated with the risk of developing COVID-19. The chemokine receptor-5 (CCR5) maps to this region, and the common 32 bp deletion variant (Δ32) has been associated with the extent of inflammatory disease and the outcome in several viral diseases. Several studies have also suggested that the pharmacological targeting of CCR5 could reduce the impact of SARS-CoV-2 infection and the severity of COVID-19. We sought to investigate whether this polymorphism was associated with the risk of moderate-severe COVID-19.We genotyped 294 patients who required hospitalization due to COVID-19 (85 were severe cases) and 460 controls. We found a significantly lower frequency of CCR5-Δ32 among the COVID-19 patients (0.10 vs 0.18 in controls; p=0.002, OR=0.48, 95%CI=0.29-0.76). The difference was mainly due to the reduced frequency of CCR5-Δ32 carriers in the severe, significantly lower than in th...
BMC Research Notes
The CCR5Δ32 allele is not a major predisposing factor for severe H1N1pdm09 infection2014 •
International Immunopharmacology
Variant-genetic and transcript-expression analysis showed a role for the chemokine-receptor CCR5 in COVID-19 severity2021 •
The Journal of Infectious Diseases
Variants of the Chemokine Receptor CCR5 Are Associated with Severe Bronchiolitis Caused by Respiratory Syncytial Virus2003 •
2021 •
COVID-19, the pandemic infection caused by SARS-CoV-2, may take highly variable clinical courses, ranging from symptom-free and pauci-symptomatic to fatal disease. The goal of the current study was to assess the association of COVID-19 clinical courses controlled by patients’ adaptive immune responses without progression to severe disease with patients’ Human Leukocyte Antigen (HLA) genetics, the presence or absence of near-loss-of-function delta 32 deletion mutant of C-C chemokine receptor type 5 (CCR5) and AB0 blood group antigens. We further analyzed the association of these immunogenetic background characteristics with patients’ humoral antiviral immune response patterns, assessed longitudinally. The study enrolled 157 convalescent adult patients followed up for up to 250 days. Univariate HLA analyses identified putatively protective HLA alleles (HLA class II DRB1*01:01 and HLA class I B*35:01, with a trend for DRB1*03:01) associated with reduced durations of disease and decreas...
Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression
Polymorphisms in the human CC chemokine receptor-3 gene1998 •
Epistemic Studies, De Gruyter
Konstitutive Bedingungen mentaler Repräsentation (Constitutive Conditions of Mental Representation)2024 •
My book investigates a characteristic and enigmatic ability of the mind: being directed towards the world (intentionality) and representing things as being a certain way (mental representation). I aim to find out in a broadly naturalistic spirit what the constitutive conditions of representational intentionality are and how sensory mechanisms must be structured to realize the first form of mind. By combining analytic, empirical and phenomenological approaches to animal mind and perception, I show that the mainstream approach – the "tracking" paradigm of mental representation– is insufficient to explain two key features of intentional states, distality and veridicality. I present an alternative approach developing primitive forms of objectivity and subjectivity. Dealing with mental representation, the project has deep implications for the most important and highly debated concept of philosophy of mind, cognitive science and artificial intelligence today. Check out: https://www.degruyter.com/document/doi/10.1515/9783111380551/html?lang=en#overview
2019 •
Sebagai mahasiswa sistem informasi kita dituntut untuk memahami bagaimana manajemen proyek sistem informasi itu agar ilmu ini bisa di implementasikan dalam kehidupan nyata.Untuk mengetahui secara lebih jelas tentang manajemen proyek sistem informasi maka selanjutnya akan dibahas lebih mendetail mulai dari pengertian hingga metodologi umum pelaksanaan proyek sistem informasi.
IOP Conference Series: Earth and Environmental Science, Volume 1283, Issue 1, id.012016, 18 pp.
Assessing the Efficacy of Spatial Planning and Architecture in New Cities: A Case Study of Galala City and Its Implications for Responsible Urban Development2015 •
Malaysian Journal of Consumer and Family Economics
Journal Article MAJCAFE 2018.PDF2018 •
Kabbalah in America: Ancient Lore in the New World
The Calf Awakens: Language, Zionism and Heresy in Twentieth-Century American Hasidism2020 •
Journal of Food Protection
The National Advisory Committee on Microbiological Criteria for FoodsHistoria ecclesiastica I Colloquia mediaevalia Pragensia
Ľudová zbožnosť vo včasnom stredoveku na príklade príveskov-amuletov2007 •
2011 •
Frontiers in cardiovascular medicine
Effect of on-pump vs. off-pump coronary artery bypass grafting in patients with non-dialysis-dependent severe renal impairment: propensity-matched analysis from the UK registry dataset2024 •
Gragoatá
Cruzando Fronteiras: A Promoção De Direitos Com Refugiados Nas Práticas De Ensino De Línguas2017 •
2008 International Multiconference on Computer Science and Information Technology
Reliability of malfunction tolerance2008 •
Revista Ideales
La Investigación Formativa Como Estrategia Pedagógica y Social en La Modalidad a Distancia De La Universidad Del Tolima2013 •
Journal of Magnetic Resonance
Standard-based method for proton–electron double resonance imaging of oxygen2011 •
BMC Musculoskeletal Disorders
Unusual localization and presentation of osteoid osteoma mimicking juvenile spondyloarthritis: a case report2019 •