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Capturing “Trial-to-Trial” Variations in Human Brain Activity: From Laboratory to Real World University Press Scholarship Online Oxford Scholarship Online The Dynamic Brain: An Exploration of Neuronal Variability and Its Functional Significance Mingzhou Ding, PhD and Dennis Glanzman,PhD Print publication date: 2011 Print ISBN-13: 9780195393798 Published to Oxford Scholarship Online: September 2011 DOI: 10.1093/acprof:oso/9780195393798.001.0001 Capturing “Trial-to-Trial” Variations in Human Brain Activity: From Laboratory to Real World Akaysha C. Tang Matthew T. Sutherland Zhen Yang DOI:10.1093/acprof:oso/9780195393798.003.0009 To understand cognition and emotion in the real world, it is critical to investigate the phenomena of interest within the rich context of moment-to-moment variations in the real world, which we assume is at least in part encoded in the high-dimensional state of the brain. Here the chapter reviews empirical evidence from a series of novel validation studies that demonstrate the technical capabilities of one blind source separation (BSS) algorithm—second-order blind identification (SOBI)—in enabling neuronscientists and clinicians to investigate human brain functions, cognition, and behavior using the electroencephalography (EEG). The chapter concludes that by shifting from an EEGsensor-based to a neuronal-source-based characterization of brain states, one may better capture the rich context of moment-to-moment variations in the real world. Page 1 of 2 PRINTED FROM OXFORD SCHOLARSHIP ONLINE (www.oxfordscholarship.com). (c) Copyright Oxford University Press, 2014. All Rights Reserved. Under the terms of the licence agreement, an individual user may print out a PDF of a single chapter of a monograph in OSO for personal use (for details see http://www.oxfordscholarship.com/page/privacy-policy). Subscriber: Florida International University; date: 04 February 2015 Capturing “Trial-to-Trial” Variations in Human Brain Activity: From Laboratory to Real World Keywords: independent component analysis, blind source separation, EEG, context effect, source localization, internal validity, external validity, reliability, cross-subject, reliability, cross-time, efficiency Oxford Scholarship Online requires a subscription or purchase to access the full text of books within the service. Public users can however freely search the site and view the abstracts and keywords for each book and chapter. Please, subscribe or login to access full text content. If you think you should have access to this title, please contact your librarian. To troubleshoot, please check our FAQs , and if you can't find the answer there, please contact us . Page 2 of 2 PRINTED FROM OXFORD SCHOLARSHIP ONLINE (www.oxfordscholarship.com). (c) Copyright Oxford University Press, 2014. All Rights Reserved. Under the terms of the licence agreement, an individual user may print out a PDF of a single chapter of a monograph in OSO for personal use (for details see http://www.oxfordscholarship.com/page/privacy-policy). Subscriber: Florida International University; date: 04 February 2015