Shampoos an Overview

Anti-inflammatory & anti-allergy agents in medicinal chemistry, 2016

Non-steroidal anti-inflammatory drugs (NSAIDS) are clinically used as anti-inflammatory, analgesic and antipyretic agents but they have the drawbacks of causing gastric irritation and gastric ulceration. Recently, quinoline derivatives have shown significant anti-inflammatory and less ulcerogenic activity. The present study deals with the synthesis and pharmacological assessment of a series of novel quinoline derivatives bearing azetidinones scaffolds as anti-inflammatory and analgesic agents. A series of newer 3-chloro-1-(substituted)-4-(tetrazolo [1,5-a]quinolin-4-yl)azetidin-2-one derivatives (6a-l) was synthesized starting with acetanilide (1). Initially, acetanilide (1) was allowed to react with Vilsmeier-Haack reagent (DMF + POCl3) to form 2-chloro-3-formyl quinoline (2). The 2-chloro-3-formyl quinoline (2) was further treated with p-toluenesulphonic acid and sodium azide which yielded Tetrazolo [1,5-1] quinoline-4-carbaldehyde (3). The reaction of formyl group with various su...

Sustainability

Shampoo prepares surfactants to remove dirt, surface grease, and skin debris from hair, shaft, and scalp without harming the user. This study aimed to formulate herbal shampoo using Ethiopian plant extracts and evaluate their quality parameters. Herbal shampoos were formulated using seed oil extracts of Lepidium sativum L. and Ricinus communis L., and essential oil extracts of Lippia adeonsis Hochst ex. Walp koseret, along with other ingredients. The formulated herbal shampoos were evaluated for their organoleptic and physicochemical properties such as pH, surface tension, viscosity, dirt dispersion, antimicrobial activities, and stability. When the investigation data were assessed, the formulations were pleasant and attractive, produced sufficient foam, and showed suitable cleansing activities. The pH values were in a range 5.90 ± 0.22–7.45 ± 0.19, and lower surface tension (23.39 ± 0.20–31.89 ± 1.04 dyne/cm) together with acceptable viscosity with good shearing properties were obt...

Journal of emerging technologies and innovative research, 2021

American Journal of PharmTech Research, 2015

The synthesis of novel azetidinone containing quinoline derivatives involves, cyclization reaction to form quinoline-3-carbaldehyde followed by Schiff's base formation and finally resulted into azetidinone derivatives as target molecules. Firstly, quinoline-3-carbaldehyde was prepared from N-phenylacetamide with POCl 3 in dimethyl formamide (Vilsmeyer Hacck reagent) under reflux through cyclization. The formed quinoline derivative was treated with substituted aromatic amines in presence of glacial acetic acid through grindstone process to get Schiff's bases of quinoline derivatives. Finally, these Schiff's bases were allowed to react with acetyl chloride and triethyl amine in presence of dimethyl formamide under reflux to achieve azetidinone ring formation resulting in the novel azetidinone containing quinoline derivatives. The synthesized compounds were identified by melting point and TLC as well as characterized by IR spectroscopy. The titled compounds were screened for antibacterial activity using agar well diffusion method against Staphylococcus aureus, Escherichia coli. Most of the compounds showed good antibacterial activity against G(-)ve bacteria and mild activity against G(+)ve bacteria when compared to the standard, Amoxicillin. QSAR study was performed, results revealed that the target molecules possess higher logP values which indicates that the physicochemical parameters proportional to the biological activity. Due to its high logP value the target molecules may possess CNS activities.

INTERNATIONAL JOURNAL OF PHARMACEUTICAL QUALITY ASSURANCE

Cosmetics have fascinated the human race for ages. Cosmetics have been found to benefit in several ways such as enhancing appearance, protection, cleansing etc. If fortified with the benefit of herbal ingredients, these personal care products have proven to be a boon for many. The current study involves the formulation of seven shampoos using different herbal extracts and their comparative investigation for physicochemical and performance characteristics. Various herbal extracts using components such as coffee, fenugreek, green tea, bringaraj, onion seeds, orange oil, and lemon oil were developed and compared against the marketed standard. The effect of various extracts on the parameters such as surface tension, foam test and foam stability test, viscosity, cleansing test, sag test, dirt dispersion, wetting time and pH was successfully tested. All the formulations were found to be beneficial in eliminating oil, dirt, and dandruff, encouraging smooth, silky hair appearance, fortifyin...

2011

Asian Journal of Pharmaceutical and Clinical Research, 2020

Objective: This study evaluated the phytochemical compounds, antioxidant, and antimicrobial activities of Vernonia amygdalina (VA) leaf extract and used it as an auxiliary herbal constituent in natural hair shampoo. Methods: VA leaf was macerated in various solvents. All crude extracts were phytochemical compounds screened and determined the antioxidant and antimicrobial activities before formulating a natural shampoo formula. Natural shampoos were evaluated with physic-chemical properties and sensory satisfaction. Results: About 95% ethanolic extract was the most suitable substrate for product development. It reveals the inhibition zone from 7.00±0.00 to 15.00±1.00 mm and possesses a broad spectrum of antibacterial agents against both Gram-positive and Gram-negative bacteria. The MICs and minimum bactericidal concentrations value ranged from 6.250 to 100 mg/ml and 25 to >200 mg/ml, respectively. About 95% ethanolic extract also revealed high antioxidant activity. The IC 50 value of DPPH of 95% ethanolic extract was 1.88±0.02 μg/ml (% inhibition of 85.73±0.01) and the ferric reducing ability power was 23.00±0.50 mg AAE/100 gDW. These high biological activities may be due to a broad range of phytochemical compounds, including saponins, tannins, flavonoids, terpenoids, steroids, cardiac glycosides, and alkaloids. Conclusions: The VA leaf was suitable to use as an ingredient in natural shampoos with a low detrimental effect on normal skin flora. The shampoo with 0.00188% of 95% ethanolic extract was the most suitable formula in terms of characteristics and stability. This formula also obtained the highest satisfaction level under our sensory evaluation.

International Journal of Pharmacy and Pharmaceutical Sciences, 2016

The aim of present research work was to formulate herbal shampoo using aqueous extracts of Aloe vera (Korpad), Acacia cancina (Shikakai), Sapindus Mukorossi (Reetha) and Phyllanthus emblica (Amla) as a replacement to synthetic surfactants and carry out a comparative analysis for their cleansing activity. Methods: Herbal shampoo formulation was carried out using different phytoextracts mixed in a definite proportion. Phytochemical screening was carried out to estimate total phenolic, flavonoid and saponin content. CAPB (Cocoamido propyl betain) was used as a conditioner for the formulation. Further, the formulations were analyzed for physicochemical properties such as pH, dirt dispersion, detergency ability and foaming ability which are prerequisite for shampoo preparations. Results: It was observed that Phyllanthus emblica formulation showed the highest cleaning ability i.e. 96% due to the presence of rich flavonoid content while Acacia cancina formulation contributed the highest detergency ability i.e. 94.96% due to the presence of rich saponin content. All the formulation showed high foaming ability and stability which is a prerequisite of shampoo preparations. Conclusion: The results obtained during experimentation clearly indicate a promising formulation of quality enhanced herbal shampoo with a unique aroma, colour and potential for cleaning and foaming ability.

2010