Ben Abdelaziz et al. BMC Pediatrics (2017) 17:208 DOI 10.1186/s12887-017-0965-y RESEARCH ARTICLE Open Access Full title: peripheral venous catheter complications in children: predisposing factors in a multicenter prospective cohort study Rim Ben Abdelaziz1,2,3,8* , Habiba Hafsi1, Hela Hajji1, Hela Boudabous1,2,3, Amel Ben Chehida1,2,3, Ali Mrabet2,4, Khadija Boussetta2,5, Sihem Barsaoui2,6, Azza Sammoud2,7, Mourad Hamzaoui2,8, Hatem Azzouz1,2,3 and Néji Tebib1,2,3 Abstract Background: Peripheral venous catheterization (PVC) is frequently used in children. This procedure is not free from potential complications. Our purpose was to identify the types and incidences of PVC complications in children and their predisposing factors in a developing country. Methods: We conducted a prospective observational multicenter study in five pediatric and pediatric surgery departments over a period of 2 months. Two hundred fifteen PVC procedures were conducted in 98 children. The times of insertion and removal and the reasons for termination were noted, and the lifespan was calculated. Descriptive data were expressed as percentages, means, standard deviations, medians and interquartile ranges. The Chi2 test or the Fisher test, with hazard ratios and 95% confidence intervals (CI95%), as well as Student’s t test or the Mann-Whitney U test were used to compare categorical and quantitative variables, respectively, in groups with and without complications. The Spearman test was used to determine correlations between the lifespan and the quantitative variables. The Kruskal Wallis test was used to test for differences in the median lifespan within 3 or more subgroups of a variable. Linear regression and logistic binary regression were used for multivariate analysis. A p-value <0.05 was considered significant. Results: The mean lifespan was 68.82 ± 35.71 h. A local complication occurred in 111 PIVC (51.9%) cases. The risk factors identified were a small catheter gauge (24-gauge) (p = 0.023), the use of a volume-controlled burette (p = 0.036), a longer duration of intravenous therapy (p < 0.001), a medical diagnosis of respiratory or infectious disease (p = 0.047), the use of antibiotics (p = 0.005), including cefotaxime (p = 0.024) and vancomycin (p = 0.031), and the use of proton pump inhibitors (p = 0.004).The lifespan of the catheters was reduced with the occurrence of a complication (p < 0.001), including the use of 24-gauge catheters (p = 0.001), the use of an electronic pump or syringe(p = 0.036) and a higher rank of the intravenous device in each patient (p = 0.010). (Continued on next page) * Correspondence: rimelair@gmail.com; rimbenabdelaziz@yahoo.fr 1 Department of Pediatrics, La Rabta Hospital, Tunis, Tunisia 2 Université Tunis El Manar, Faculté de Médecine de Tunis; LR12SPO2 les maladies héréditaires du métabolisme investigation et prise en charge, Tunis, Tunisia Full list of author information is available at the end of the article © The Author(s). 2017 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. Ben Abdelaziz et al. BMC Pediatrics (2017) 17:208 Page 2 of 11 (Continued from previous page) Conclusions: PVC complications were frequent in our pediatric departments and are often associated with misuse of the device. These results could engender awareness among both doctors and nurses regarding the need for rationalization of the use of PVC and better adherence to the recommendations for the use of each drug and each administration method. Keywords: Peripheral venous catheter, Children, Complication, Extravasation, Lifespan, Prevention Background Peripheral venous catheterization (PVC) is one of the most frequently used procedures in hospitalized children. It is estimated that more than 80% of patients undergo this procedure during hospitalization [1]. In addition to the administration of intravenous fluids, drugs, blood products and parenteral nutrition, peripheral venous catheters are also inserted prophylactically before procedures and in unstable patients for emergency use [2].Despite its frequent use, intravenous cannulation is not without risks. It is a leading source of procedure-related pain in the hospital [3, 4].Complications such as clotting, occlusion, leakage, infiltration, extravasation, phlebitis and infection can also occur [5]. In neonatal intensive care units, local complications occur in up to 97%of PVCs [6–9], and the catheters have a median lifespan of 23–40 h [6, 10]. Studies in pediatric departments have reported a lower incidence of complications in approximately a quarter of PVC cases [11–13], with catheters having a median lifespan ranging from 29 to 60 h [13–16]. Various risk factors of local PVC complications have been identified in these studies, which may be related to patient characteristics (a younger age [15, 16]), underlying conditions such as diabetes or cancer [12], the nature of drugs or fluids used (antibiotics, corticosteroids, hypertonic solution, etc) [6, 17], the site of insertion (the antecubital fossa [11, 18],wrist [15] and ankle [16]), the characteristics of the catheter(a smaller gauge [15]), drug and medication administration methods (infusion pumps [12]), and the means of maintaining and securing the PVC (the use of flushes and splints improves PVC patency [15, 19]). In recent years, significant technological innovations have been developed to promote the insertion use and means of securing peripheral intravenous catheters (PIVC). Cannula insertion can be facilitated with vein visualization devices or ultrasound guidance [20–22]. Medical-grade tissue adhesives (cyanoacrylates) and antimicrobial-impregnated dressings have shown promise in reducing local and infectious complications associated with intravenous therapy [23–25]. According to recent data, clinical practice and international best practice recommendations for the use, care and maintenance of PVCs have considerably changed [26]. In Tunisia, as in many other developing countries, new technologies are not available because of their high cost. Even basic products such as chlorhexidine or transparent film dressings are not routinely used in pediatric units. Therefore, the available data on PVC complications in children, their risk factors and recommendations for best practice are not systematically generalizable to our circumstances. Our study aimed to (i) provide data on the lifespan of PIVC in children, (ii) describe the incidence and the types of complications of PVC in Tunisian pediatric departments, and (iii) identify any significant risk factors for PVC failure. Methods Study design and settings We conducted a prospective, multicenter study over a period of 2 months, including April and May of 2015.Two university hospitals in Tunis participated: The Children’s Hospital Béchir Hamza of Tunis (CHBH), the pediatric Hospital in Tunisia, and La Rabta Hospital (LRH),a predominantly adult hospital hosting a pediatric department specialized in inherited metabolic diseases. In total, four pediatric departments and one pediatric surgery department participated in the study. The overall hospitalization capacity of these departments is 260 beds. Only the pediatric department of LRH is a mother-child ward. In the other wards, children are hospitalized by themselves and mothers are allowed to visit for a few hours during the day. Sample and recruitment All patients admitted to the hospital and requiring at least one PIVC were included. Children referred from another department with a pre-existing PIVC were excluded. Any children who underwent PIVC placement later during hospitalization were included. Children transferred out with a PIVC in place were also noted, but they were not followed up in the wards. These PVCs were labeled as non-complication cases. We calculated that a sample of at least 200 PVCs was clinically practical and sufficient to provide a heterogenous sample containing all important factors that contribute to complications and would be large Ben Abdelaziz et al. BMC Pediatrics (2017) 17:208 enough to overcome potential biases [27].Therefore, we used a convenient study period of 2 months based on feasibility and the number of patients treated in the participating wards. Study participation was initiated by a member of the research team during routine morning visits who collected baseline data and attached the data collection form to the patient’s medical file. Each patient was given a case number, and each catheter was numbered in the order of the time of insertion. Outcome variables The primary outcomes were (i) the lifespan of the PIVC (calculated from the time of insertion to the time of removal) and (ii) the occurrence of a complication (occlusion, infiltration, phlebitis, necrosis, displacement or infection). Both parameters were defined by clinicians per their standard clinical judgment. No formal assessment tool was used. The secondary outcomes were variables with potential significant associations with PVC complications, including patient characteristics (age, gender, medical diagnosis), indication for PVC, PIVC gauge, the site of insertion, medications and fluids, and administration method. These specific variables were chosen based on previous literature reporting risk factors of PVC complications in children with consideration for the feasibility of their measurement given the limited human resources dedicated to this study. Data collection Details related to the primary and secondary outcome variables were collected on a paper form designed for this study. Two research nurses dedicated to the study completed the forms during business hours based on information from monitoring sheets used in each ward. Every day, each nurse went into one of the two hospitals on an alternating basis to ensure a daily presence in the study sites. Catheter placement and monitoring The participating hospitals do not have special intravenous insertion teams, so all PIVCs were inserted by nurses who had completed PIVC insertion training. Nurses were not aware of the study. Alcohol 70%was used to decontaminate the skin and devices involved in catheter manipulation. Both 24- and 22-gauge Teflon cannulae were used (B-CAT I.V. cannula, BIÇAKCILAR®, Istanbul, Turkey and PRIMAFLON® I.V cannula, Med Devices Lifesciences Ltd., London, UK).Ultrasound and vein visualization devices were not available and were not used for PIVC insertion during the study. Tape dressings (Neoplast ® universal tape and universal tape perforated with zinc oxide, Adhe-elss.a. Sousse Tunisia) were used for the insertion site and the catheter hub. Page 3 of 11 When necessary, additional nonsterile tape, bandages and splints were used. No extension set was used between the PIVC and devices used for infusions or syringes for the administration of boluses. The infusions and medications were given by either the gravitational method (with or without a volume-controlled burette (VCB)) (Alaris® GW volumetric pump, CareFusion, Hampshire, UK and Romsons ® vented infusion set, Romsons Junior, Agra India and Infusion burette SO.F.A.P TN, Tunis, Tunisia), infusion pumps or electronic syringes (depending on their availability) (Lifepum ® Syringe pump, Well Kang Ltd., Dublin, Ireland, Perfusor ® compact, Braun and Phoenix® syringe pump, Foures, GRADIGNAN - France), or bolus injection. PIVCs were flushed with normal saline solution before use. The insertion site was assessed during nursing rounds or if a sign (from the patient himself or his mother, the medical staff or the infusion device) of potential dysfunction emerged. Dressings were replaced if they were loose or if visible ooze was noticed. In all cases, the catheters were discontinued or replaced based on clinical indications (no routine changes to the catheters). Ethical considerations The study was approved by local Clinical Research Ethics Committee. In our study there was no experimentation or intervention on patients. The manuscript did not contain any recognizable patient data, so a written informed consent was not required. Verbal parental permission was obtained and a subject’s consent was also obtained when appropriate. Statistical analysis The data were processed using SPSS Version 21 software. For categorical variables, we calculated percentages. For quantitative variables, we calculated the means, standard deviations, medians and interquartile ranges (IQRs). For intergroup comparisons, we used the Chi2 test or the Fisher exact test for categorical variables. Hazard ratios (HR) were analyzed with 95% confidence intervals (CI95%). For quantitative variables, we used Student’s t-test or the non-parametric Mann-Whitney Utest as indicated. The Spearman test was used to determine correlations between two quantitative variables (such as the lifespan of a PIVC and the age of a patient or the total duration of intravenous (IV) therapy). The Kruskal Wallis test was used to test for differences in the median lifespan within 3 or more subgroups of a variable (such as administration method and study site). For the multivariate analysis, we included variables with a p-value < 0.2 in the univariate analysis and any other variable predicted to be a potential risk factor for the outcome variables (the occurrence of complications and Ben Abdelaziz et al. BMC Pediatrics (2017) 17:208 Page 4 of 11 PIVC lifespan) based on previous literature. The forced entry method was used to introduce all predictor variables in one block. For the variable occurrence of a complication, we used logistic binary regression and for the variable PIVC lifespan, we used linear regression. A p-value <0.05 was considered significant. details of the device characteristics are given in Table 2. The gravitational method (with or without VCB) was predominantly used, accounting for 77.7% of the cases. The total duration of IV therapy was significantly longer when a VCB was used (14.91 ± 4.01 days) compared to the gravitational method (7.62 ± 4.01 days) or an infusion pump (6.23 ± 4.54 days) (p < 0.001). Results Participant characteristics PVC complications In this study, 98 children were included. The mean age was 5.2 ± 4.7 years (range 0.1–18). The medical diagnoses groups were respiratory diseases (24.5%), infectious diseases (15.3%), hematological diseases (18.3%), metabolic diseases (20.4%), dehydration (2%), surgery (6.1%), neurological diseases (3.1%) and other diseases (11.2%). The details of the participants’ characteristics are given in Table 1. Complications were observed in 111 PIVCs (51.9%)in 46 children (46%), including infiltration in 80 cases (37.2%), accidental removal in 19 cases (8.8%), phlebitis in 11 cases (5.1%) and skin necrosis in one case. No local infection or device-related bloodstream infections were observed. Among the PIVCs with complications, 67 (60%) were replaced with a new device. Factors associated with PVC complications Catheter characteristics Two hundred fifteen PIVCs were inserted with a mean of 2.28 ± 1.69 PIVCs/patient (range 1–9). Twenty-twogauge catheters were used in 53.7% of the cases. The insertion site was in the hand in 82.2% of the cases. The main indications for PVCs were drug administration in 67.8% of the cases, infusion in 24.8% of the cases and blood product transfusion in 7.5% of the cases. The Table 1 Characteristics of participants (n = 98) N (%) Male gender Median (IQR) 49 (50) Age (years) 4.5 (6.67) Site of the study Pediatric Department A of CHBH 31 (32) Pediatric Department B of CHBH 8 (8) Pediatric Department C of CHBH 22 (22) Surgery Department A of CHBH 5 (5) Pediatric Department of LRH 32 (33) Diagnosis Infection 15 (15.3) Respiratory 24 (24.5) Hematology 19 (18.3) Metabolic 18 (20.4) Dehydration 2 (2) Neurologic 3 (3.1) Surgery 6 (6.1) Other 11 (11.2) Duration of hospitalization in the study sites (days) Total duration of intravenous therapy/patient (days) CHBH Children’s Hospital Béchir Hamza, LRH La Rabta Hospital, IQR Inter-quartile range 6 (7.25) 4.5 (4.75) Among the patient- and device-related variables considered in the univariate analysis, the following variables were significantly associated with the occurrence of local complications: a small catheter gauge (24-gauge) (p = 0.023), the use of the gravitational method, especially with a VCB (p = 0.036), a shorter indwelling time (p < 0.001), a longer duration of IV therapy (p < 0.001),medical diagnosis, especially respiratory and infectious diseases (p = 0.047), the type of IV drug used, especially antibiotics (p = 0.031), including cefotaxime(p = 0.024) and vancomycin (p = 0.031), and the use of proton pump inhibitors (PPIs) (p = 0.004). All of these variables were considered in the multivariate model and the use of PPIs (p = 0.011), a longer duration of IV therapy (p < 0.001) and a shorter indwelling time (p = 0.011) were found to be statistically significant. None of the other variables, such as the ward, a patient’s age and gender, insertion site (in the hand, foot or head), the type of infusion, the administration of blood products, or the method of drug administration, contributed to the occurrence of local PVC complications. Table 3 shows the comparison of children and device characteristics in the two groups with and without complications. When we considered each type of complication individually, some variables were associated with the occurrence of a specific type of complication in the multivariate analysis. Infiltration (or extravasation) was associated with a shorter indwelling time (p < 0.001), a longer duration of IV therapy (p = 0.007), the use of antibiotics, including ceftriaxone (p = 0.035) and vancomycin (p = 0.032), and PPI use (p = 0.005). Phlebitis was associated with PPI use (p = 0.031) and ceftriaxone (p = 0.017) and vancomycin (p = 0.011) use. Accidental PIVC removal was associated with a shorter indwelling time (p = 0.011). Ben Abdelaziz et al. BMC Pediatrics (2017) 17:208 Page 5 of 11 Table 2 Characteristics of devices (N = 215) N (%) Number of devices/patient Median (IQR) 2 (2) Indwelling time (hours) 72 (48) Site of PVC insertion Dorsum of the hand 170 (78.8) Wrist 2 (1) Antecubital fossa 3 (1.5) Lower arm 2 (1) Foot 37 (17.2) Head 1 (0.5) Cannula gauge 22G (blue) 115 (53.5) 24 G (yellow) 100 (46.5) Reason for PVC insertion Infusion 145 (67.4) Medication 53 (24.7) Blood product transfusion 17 (7.9) Administration method Gravitational 114 (53) Volume-controlled burette 53 (24.7) Infusion pump 48 (22.3) Fluids 5% Dextrose 58 (27) 28 (13) 10% Dextrose 21 (9.8) Normosaline solution 9 (4.2) Drugs (one or more)/device 145 (67.4) Number of drugs/device Antibiotics (one or more)/device 114 (53) Aciclovir 7 (3.3) Paracetamol 31 (14.4) Corticosteroids 16 (7.4) Proton Pump Inhibitors 26 (12.1) Pamidronate 7 (3.2) Other 11 (5.1) 1 (1) Rhythm of device use/day (N = 165) ≤3 times 92 (42.8) > 3 times 123 (57.2) IQR Inter-quartile range PIVC lifespan and associated factors The cumulative lifespan of a PIVC was up to 15,011 h. The mean lifespan was 68.82 ± 35.71 h (range 1–168). The factors associated with PIVC lifespan were catheter gauge, the administration method, the rank of the IV device in each patient, the nature of the infusion and the study site. The mean lifespan was shorter for 24-gauge catheters (61.32 ± 33.25 h) compared to 22-gauge catheters (77.21 ± 36.26 h) (p < 0.001). When the gravitational method was used to administer infusions or drugs, the lifespan of the PIVC was longer (72.56 ± 35.85 h) when an electronic pump or syringe was used (60.03 ± 33.88 h) (p < 0.001). The lifespan of a PIVC decreased significantly with the rank of the device in the same patient (Pearson coefficient = −0.216, p = 0.001). The lifespan was shorter with the use of 10% dextrose (49.95 ± 28.70 h) compared to 5% dextrose (74 ± 39.39 h) and normal saline solutions (98.67 ± 47 h) (p = 0.005). Participants from the pediatric department of LRH had the shortest PIVC lifespan (57.14 ± 33.34 h) compared to the other departments (lifespan ranging from 65 ± 28.73 to 96 ± 33.94 h)(p = 0.005). When we considered the subgroup of PIVCs with complications, we found that the difference in lifespan between the different study sites was non-significant (p = 0.080). In the subgroup of devices without complications, the lifespan was significantly lower in the pediatric department of LRH(64.7 ± 32.56 h) than in the other wards (lifespan ranging from 86 ± 34 to 96 ± 33 h)(p = 0.001). In the multivariate analysis, the use of 10% dextrose was the only factor associated with a reduced PIVC lifespan (p = 0.003). Table 4 shows the details of the comparison of the means and standard deviations PIVC lifespan between subgroups of patients and devices characteristics. Discussion Local PVC complications were common in our pediatric departments, which were observed in approximately half of the devices and children. The complication rate was higher than those from other studies on comparable pediatric populations (not including neonatal and intensive care units) [11, 12]. These studies reported PVC complications in approximately25% of devices. The most frequent complications were infiltration and accidental removal, affecting 37.2% and 17.1% of devices, respectively. These rates were higher than the results of Malyon and al. who found rates of 14% and 5% for these complications [11] and de Lima Jacinto et al. who reported infiltration in 16% of children [12]. We noted one case of skin necrosis, which was a result of a late diagnosis of extravasation [28] partially due to a lack of monitoring. In the wards where the study was conducted, the nurse/patient ratio was variable, ranging from 1:4 to 1:10 and even as low as 1:13 to 1:20 during night shifts, affecting the quality of monitoring and increasing the risk of delayed diagnosis of complications and the occurrence of tissue damage [6]. The PIVC lifespan in our study was longer than that found in the literature (68.82 ± 35.71 (range 1–168)). Studies evaluating this variable in children are scarce. The mean lifespan in these studies ranges from 29.53 to Ben Abdelaziz et al. BMC Pediatrics (2017) 17:208 Page 6 of 11 Table 3 Comparison of children and device characteristics in the two groups with and without complications Characteristics Complication (N = 109) No Complication (N = 106) Univariate analysis Median ± IQR N (%) Median ± IQR N (%) p-value Male gender 59 (54.1) 57 (53.8) 0.958 Age (years) 3 (5.7) 5 (6.7) 0.658 0.527 Duration of hospitalization (days) 13 (7) 8 (10) 0.093 0.383 HR [CI95%HR] Multivariate Analysis p-value Total duration of IV therapy/patient (days) 11(10) 7 (8.75) <0.001 0.011 Dwell time (hours) 48 (48) 72 (51.2) <0.001 <0.001 Rank of the PVC/patient 2 (2) 1 (1) 0.352 Pediatric Department A of CHBH 30 (27.5) 33 (31.1) 0.764 Pediatric Department B of CHBH 14 (12.8) 10 (9.4) Study site Pediatric Department C of CHBH 34 (31.2) 29 (27.4) Surgery Department A of CHBH 2 (1.8) 4 (3.8) Pediatric Department of LRH 29 (26.6) 30 (28.3) Infection 27 (24.8) 19 (17.9) Respiratory 38 (34.9) 27 (25.5) Hematology 14 (12.8) 21 (19.8) Metabolic 9 (8.3) 21 (19.8) Other 21 (19.3) 18 (17) Hand 86 (78.9) 85 (80.2) Foot 20 (18.3) 17 (16) Other 3 (2.8) 4 (3.8) 22G (blue) 50 (45.9) 65 (61.3) 24 G (yellow) 59 (54.1) 41 (38.7) 76 (69.7) 69 (65.1) Diagnosis 0.047 0.336 0.0547 0.714 Site of PVC insertion Cannula gauge 0.023 1.87 [1.09–3.22] 0.164 Reason for PVC insertion Medication Infusion 26 (33.9) 27 (25.5) Blood product transfusion 7 (6.4) 10 (9.4) 52 (47.7) 62 (58.5) 0.656 0.769 0.036 0.216 Drug/infusion administration method Gravitational Volume-controlled burette 35 (32.1) 18 (17) Infusion pump 22 (20.2) 26 (24.5) Administration rhythm ≥3 times/day 60 (55) 63 (59.4) 0.516 0.703 Number of medications/device 1 (1) 1 (1) 0.150 0.527 Antibiotics 68 (62.4) 46 (43.4) 0.005 Ampicillin 9 (8.3) 10 (9) 0.761 Amoxicillin clavulanate 9 (8.3) 9 (8.3) 0.951 Cefotaxim 29 (26.6) 15 (14.2) 0.024 Ceftriaxone 3 (2.8) 2 (1.9) 0.674 Ceftazidime 9 (8.3) 7 (6.6) 0.644 2.16 [1.25–3.73] 0.615 2.19 [1.1–4.39] 0.545 Ben Abdelaziz et al. BMC Pediatrics (2017) 17:208 Page 7 of 11 Table 3 Comparison of children and device characteristics in the two groups with and without complications (Continued) Characteristics Fosfomycin Complication (N = 109) No Complication (N = 106) Univariate analysis Median ± IQR N (%) Median ± IQR N (%) p-value 1 (0.9) 3 (2.8) 0.365 Vancomycin 11 (10.1) 3 (2.8) 0.031 Amikacin 7 (6.4) 4 (3.8) 0.378 Paracetamol 11 (10.1) 20 (18.9) 0.067 Aciclovir 5 (4.8) 2 (1.9) 0.244 Proton Pump Inhibitors 20 (18.3) 6 (5.7) 0.004 Corticosteroids 10 (9.2) 6 (5.7) 0.326 Pamidronate 2 (1.8) 5 (4.7) 0.275 0.445 Multivariate Analysis HR [CI95%HR] p-value 3.86 [1.04–14.29] 0.104 0.572 3.74 [1.44–9.74] 0.011 Infusate 10% dextrose 10 (34.5) 11 (37.9) 5% dextrose 16 (55.2) 12 (41.4) Normosaline 3 (10.3) 6 (20.7) IQR Inter-quartile range, HR Hazard ratio, CI95%HR: Confidence interval to 95% of the hazard ratio 51 h, with significant variations (1 to 136 h) [6, 8, 17, 29, 30]. The PIVC lifespan was shorter with the use of 24gauge catheters compared to 22-gauge catheters and electronic pumps or syringes compared to the gravitational method, a higher rank of the IV device in a patient, and the use of 10% dextrose solution compared to 5% dextrose and normal saline solutions. Only the use of 10% dextrose remained significant in the multivariate analysis. Gupta et al. studied the lifespan of PIVCs in a neonatal intensive care unit in India. He found no association between PIVC lifespan and the risk factors identified in our study. The use of cefotaxime was the only factor that reduced the lifespan of PIVCs with complications in this study [6]. No other studies have reported risk factors associated with a shorter PIVC lifespan, but all factors identified in our study were associated with PVC complications in the literature [12, 28]. Devices with complications had a shorter lifespan than those without complications. The literature on this subject is conflicting. De Lima Jacinto reported that complications were associated with a shorter indwelling time [12], while Malyon et al. found that indwelling time was longer in PIVCs exhibiting complications and investigated reasonable expectations regarding PIVC indwelling time in the acute pediatric population [11]. A recent review analyzed data from seven randomized controlled trials that compared routine removal of peripheral IV catheters with removal only when clinically indicated in hospitalized or community patients receiving continuous or intermittent infusions [31]. The authors found no evidence to support changing catheters every 72 to 96 h. Consequently, they suggested that healthcare organizations consider a policy in which catheters are changed only if clinically indicated. We identified many risk factors associated with complications, but the ones that remained significant in the multivariate analysis were a longer duration of IV therapy, and the use of PPIs, ceftriaxone and vancomycin. Unlike other factors that have already been reported in the literature [6, 8, 12, 30, 32, 33], the association between the use of PPIs and the occurrence of PVC complications is a novel finding. We did not find any studies reporting on or attempting to explain this finding. Our investigations after the study revealed that in four of the participating wards, administration recommendations for PPIs and other drugs were not respected. PPIs and corticosteroids were administered via direct bolus injection rather than slow infusion. Vancomycin was administered over 20–30 min, which is less than the recommended time (≥1 h). These practices were due to the lack of infusion pumps. The nurses reduced administration time to enable the use of the pumps in more patients. Therefore, one of the requirements to reduce complications in our pediatric departments is to have enough infusion pumps to administer medications in accordance with the recommendations and ensure the safe use of these devices [34]. The complication rate was significantly higher in the VCB subgroup compared to the standard gravitational drip and infusion pump subgroups. To our knowledge, this result has not been reported previously. This finding may be due to the lack of infusion pumps in our pediatric departments (1 pump/10–20 patients in each ward). Therefore, care providers tend to use VCBs rather than pumps to administer medications and infusions, especially in neonates and young infants. This device is indicated for short infusions (<24 h) with a 21-gauge Ben Abdelaziz et al. BMC Pediatrics (2017) 17:208 Page 8 of 11 Table 4 comparison of PVC lifespan means and standard deviations between subgroups of patients and devices characteristics Male gender yes no mean ± SD mean ± SD 73.26 ± 36.88 65.84 ± 34.04 p-value univariate Spearman coefficient p-value multivariate 0.132 Age (years) 0.612 −0.035 Duration of hospitalization (days) 0.643 0.032 Total duration of IV therapy/patient (days) 0.551 0.041 Rank of the PVC/patient 0.001 −0.216 0.509 0.005 0.160 0.019 0.163 Study site Pediatric Department A of CHBH 77.33 ± 35.66 Pediatric Department B of CHBH 65 ± 28.73 Pediatric Department C of CHBH 73.52 ± 37.3 Surgery Department A of CHBH 96 ± 33.94 Pediatric Department of LRH 57.14 ± 33.34 Diagnosis Infection 68.76 ± 33.47 Respiratory 72.31 ± 37.18 Hematology 76.58 ± 34.27 Metabolic 75.2 ± 36.31 Other 56.71 ± 34.86 0.109 0.582 0.590 0.068 <0.001 0.610 0.690 0.979 0.009 0.233 Site of PVC insertion Hand 70.41 ± 36.04 Foot 66.91 ± 34.91 Other 70.22 ± 35.54 Cannula gauge24 G (yellow) 61.33 ± 33.25 77.21 ± 36.26 Reason for PVC insertion Medication 71.16 ± 35.21 Infusion 66.21 ± 38.83 Blood product transfusion 69.62 ± 30.62 Use of infusion pump 72.56 ± 35.85 60.30 ± 33.88 Number of medications/device 0.614 0.041 0.330 Administration rhythm ≥3 times/day 0.220 0.004 0.444 Antibiotics 71.06 ± 37.45 68.42 ± 33.77 0.590 67.89 ± 41.91 70.01 ± 35.17 0.806 Amoxicillin clavulanate 65.33 ± 34.74 70.23 ± 35.85 0.579 Cefotaxim 68.73 ± 33.38 70.1 ± 36.37 0.820 Ceftriaxone 86 ± 33.49 69.43 ± 35.75 0.306 Ceftazidime 79.25 ± 32.88 69.06 ± 35.89 0.273 Ampicillin Fosfomycin 69.21 ± 35.43 102 ± 40.90 0.069 Vancomycin 66.86 ± 39.02 70.03 ± 35.56 0.749 Amikacin 0.812 0.418 82.72 ± 20.22 69.12 ± 36.26 0.069 0.440 Paracetamol 86.71 ± 32.6 66.97 ± 35.5 0.004 0.164 Aciclovir 61.71 ± 23.42 70.31 ± 36.07 0.533 Proton Pump Inhibitors 59.36 ± 34.29 71.26 ± 35.75 0.111 Corticosteroids 59.03 ± 28.06 70.69 ± 36.17 0.210 0.474 Ben Abdelaziz et al. BMC Pediatrics (2017) 17:208 Page 9 of 11 Table 4 comparison of PVC lifespan means and standard deviations between subgroups of patients and devices characteristics (Continued) Pamidronate yes no p-value univariate mean ± SD mean ± SD 49.71 ± 20.85 70.50 ± 35.94 Spearman coefficient p-value multivariate 0.130 0.282 0.005 0.003 Infusate 10% dextrose 49.95 ± 28.70 5% dextrose 74 ± 39.39 Normal saline 98.67 ± 47 SD Standard deviation, IV Intravenous, PVC Peripheral venous cannula, CHBH Children’s Hospital Béchir Hamza, LRH La Rabta Hospital cannula or larger. The main reported reason for complications related to this device is misuse [35]. In our study, VCBs were used with small gauge catheters and the mean duration of IV therapy with VCBs (14.91 ± 4.01 days) was longer than recommended and significantly longer compared with the gravitational method (7.62 ± 4.01 days) or infusion pumps (6.23 ± 4.54 days) (p < 0.001). In addition, the height of the infusion bag in relation to the patient must be 80 cm (Documentation technique ASEPT INMED. Régulateur de debit DosiFlow®). We found that these requirements were ignored among nurses in all wards that participated in our study. Sixty percent of failed PIVCs were replaced, suggesting that the other 40% were unnecessary and could have been removed earlier. This result is consistent with the data from Malyon et al. who reported that only the half of failed PIVCs were replaced [11]. Limm et al. reported that half of PIVCs inserted in the emergency department was unused 72 h later [36].In the pediatric department of LRH, the lifespans of all PIVCs and those without complications were significantly shorter than those in other departments in CHBH. This difference was not observed in the devices exhibiting complications. Since routine PIVC replacement was not implemented in the participating wards, this result suggests that in the pediatric department of LRH, nurses tend to remove unused PIVCs earlier than in other wards. Therefore, the staff in these other wards needs to be educated regarding the removal of useless PIVCs to reduce the risk of PVC complications [11]. We also found that PVC complications were associated with a longer total duration of IV therapy. This is consistent with the data in the literature [12]. Rationalizing the use of IV therapy may contribute to reducing the PVC complication rate in our hospitals. In our study, practices for PIVC insertion, dressing, safeguarding and maintenance were different from international standards [26]. Therefore, we considered that these practices, in addition to the other factors identified in our study, may have contributed to the higher rate of complications compared to the literature. In fact, it is known that PIVC dressings play a vital role in preventing catheter complications [37]. In our study, nurses used tape for PIVC dressings while Malyon et al. used bordered polyurethane dressings (BPU) [11]. Livesley and Richardson compared these two methods and found that peripheral venous catheter failure occurred less frequently in the tape group than in the bordered transparent dressing group [38]. However, replacing tape dressings with polyurethane dressings is not a priority for us in reducing the rate of PVC complications since polyurethane dressings are costly and unavailable in our hospitals. Splinting was not routinely performed in our study. Laudenbach et al... found no differences in complication rates or types between two groups of children with and without splinting [39], while Tripathi et al. found that splints significantly prolonged PIVC survival, especially in younger patients [15]. Hugill et al. recommend the use of splints to reduce catheter movement, especially when a catheter is inserted in an area with high flexion and in neonates [25].We must consider the application of these recommendations to reduce the high rate of complications in our hospitals. For skin preparation, alcohol 70% was used in our study, but chlorhexidine 2% in combination with alcohol 70% is recommended in international guidelines [34] and was used in Malyon et al’s study [11]. Studies comparing these two methods confirmed the superiority of chlorhexidine solution in reducing bacterial contamination or colonization on a device. No significant differences were noted in terms of displacement or infiltration between the two methods [40, 41]. The available data are not sufficient to determine whether the skin preparation procedure contributed to the relatively high rate of PVC failure in our study. Further investigations are required to determine whether to use chlorhexidine 2% in combination with alcohol 70% routinely, especially because this product is not available in all of our public hospitals. Recently, the use of chlorhexidine 2% in combination with alcohol 70% was introduced in CHBH. Therefore, a study should be conducted to evaluate the Ben Abdelaziz et al. BMC Pediatrics (2017) 17:208 effect of this change in practice on the PVC-related complication rate in this hospital. Strengths and limitations Our study is the first multicenter cohort study on PVC complications in a tertiary pediatric population in a developing country. Our results could be regarded as preliminary data for the implementation of practices to reduce the incidence of PVC complications in children in Tunisia and in other developing countries. However, a few limitations exist in this study. The lack of funding limited the number of people dedicated to data collection. The two nurses who collected the data were volunteers, as this study was part of their end-ofstudy project, and they could only be present during business hours. This could be a source of bias as some patients, especially those who were admitted and released or transferred during night shifts, and rapidly removed devices could have been missed. To some extent, this could explain the longer mean lifespan of PIVCs in our study compared to other studies in children. The variables studied were numerous, but because of limited feasibility due to limited resources for our study, we could not integrate all potential factors that could affect the occurrence of PVC complications, including details related to PIVC fixation and dressing, maintenance practices, and details regarding PIVC use (the sizes of the syringes used to administer each medication, the type of pump used, the infusion rate, and adherence to recommendations for each medication or device used) [15, 25, 39, 42–44]. These variables should be considered in future studies to evaluate actions that can be taken in our hospitals to reduce PVC-related complications. Page 10 of 11 Abbreviations CHBH: CHILDREN’S Hospital Béchir Hamza; CI95%: 95% confidence interval; HR: Hazard ratio; IQR: Interquartile range; IV: Intravenous; LRH: La Rabta Hospital; PIVC: Peripheral intravenous venous catheter; PPI: Proton pump inhibitors; PVC: Peripheral venous catheterization; VCB: Volume-controlled burette Acknowledgements The authors would like to acknowledge their collaboration with all medical and nursing staff of the Pediatric and Pediatric Surgery departments of La Rabta University Hospital and Hôpital d’enfants Béchir Hamza de Tunis who participated in the study. Funding All the authors declare there is no source of funding for this study. Availability of data and materials The datasets used and/or analyzed during the current study are available from the corresponding author upon reasonable request. Authors’ contributions RBA participated in the study design, statistical analysis of the data and manuscript drafting. HH participated in data collection, statistical analysis of the data and manuscript drafting. AM participated in the statistical analysis and manuscript drafting. HH, HBD, ABC, KB, SB,AS,MH,HA, and NT participated in data collection. The final manuscript version has been reviewed and approved by all authors. Ethics approval and consent to participate The La Rabta University Hospital Local Clinical Research Ethics Committee evaluated and approved the study protocol. All patients and their parents or legal representatives provided informed consent to participate in the study. Consent for publication Not applicable. Competing interests All authors declare that they have no competing interests. Publisher’s Note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. Author details Department of Pediatrics, La Rabta Hospital, Tunis, Tunisia. 2Université Tunis El Manar, Faculté de Médecine de Tunis; LR12SPO2 les maladies héréditaires du métabolisme investigation et prise en charge, Tunis, Tunisia. 3Université Tunis El Manar, Faculté de Médecine de Tunis; Military General Directorate of Health, department of Epidemiology and Public Health, Tunis, Tunisia. 4 Université Tunis El Manar, Faculté de Médecine de Tunis; Department of Pediatrics B, Hôpital d’enfants Béchir Hamza de Tunis, Tunis, Tunisia. 5 Université Tunis El Manar, Faculté de Médecine de Tunis; Department of Pediatrics A, Hôpital d’enfants Béchir Hamza de Tunis, Tunis, Tunisia. 6 Université Tunis El Manar, Faculté de Médecine de Tunis; Department of Pediatrics C, Hôpital d’enfants Béchir Hamza de Tunis, Tunis, Tunisia. 7 Université Tunis El Manar, Faculté de Médecine de Tunis; Department of Pediatric Surgery A, Hôpital d’enfants Béchir Hamza de Tunis, Tunis, Tunisia. 8 Department of Pediatrics, La Rabta Hospital Jabbari, 1007 Tunis, Tunisia. 1 Conclusions This study showed that the PVC-related complication rate is high in our pediatric departments. Many of the identified risk factors are preventable. Several practices can be implemented in the immediate future without additional cost, including rationalization of the use of this device, reducing the duration of IV therapy, removing unnecessary PIVCs, and better adherence to the recommendations for the use of each drug and each administration method. Improving PIVC protection using splints in smaller children and when devices are inserted in areas with high flexion should reduce infiltration and removal rates. Other actions, such as increasing the number of nurses per patient and supplying enough infusion pumps, require additional financial investments and the involvement of health authorities in our country. Further studies should be conducted to evaluate the effects of these actions on PVC complication rates in our hospitals. Received: 20 March 2017 Accepted: 8 December 2017 References 1. Waitt C, Waitt P, Pirmohamed M. Intravenous therapy. Postgrad Med J. 2004; 80(939):1–6. 2. 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