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2012, Annals of Ibadan postgraduate medicine
The spectrum of clinical manifestation in multiple myeloma (MM) ranges from asymptomatic disease to severely debilitative state. Unexplained renal disease is an indication for the investigation of patients for MM. This study is a retrospective analysis of the renal profile of patients with multiple myeloma in relation to management strategy in our institution. Medical records of 64 patients with multiple myeloma seen between 2000 and 2008 were retrospectively reviewed at an 850-bed tertiary hospital in South-Western Nigeria. The Mahn-Whitney test was used to compare laboratory features between patient with renal failure and those without renal failure. Subjects with serum creatinine ≥2mg/dL were regarded to have renal failure. Overall survival was calculated from diagnosis to death or lost to follow-up. A total of forty three patients were eligible. The renal status was categorized into three according to serum creatinine level; those with normal serum creatinine level (0.5-1.5mg/dl...
European Journal of Haematology, 2009
Journal of Clinical Oncology, 2010
Renal impairment is a common complication of multiple myeloma (MM). The estimated glomerular filtration rate (eGFR) using the Modification of Diet in Renal Disease formula is the recommended method for the assessment of renal function in patients with MM with stabilized serum creatinine. In acute renal injury, the RIFLE (risk, injury, failure, loss and end-stage kidney disease) and Acute Renal Injury Network criteria seem to be appropriate to define the severity of renal impairment. Novel criteria based on eGFR measurements are recommended for the definition of the reversibility of renal impairment. Rapid intervention to reverse renal dysfunction is critical for the management of these patients, especially for those with light chain cast nephropathy. Bortezomib with high-dose dexamethasone is considered as the treatment of choice for such patients. There is limited experience with thalidomide in patients with myeloma with renal impairment. Thus, thalidomide can be carefully administ...
Multiple Myeloma - An Overview, 2012
Archives of internal …, 1998
Background: Twenty percent of patients with multiple myeloma (MM) have renal failure. Objective: To analyze the presenting features, the response to therapy, and the factors associated with renal function recovery and survival in 94 patients with MM and renal failure. Patients ...
Archives of Internal Medicine, 1998
GSC biological and pharmaceutical sciences, 2023
Brill’s Companion to War in the Ancient Iranian Empires, 2024
Military histories of the ancient Near East rarely factor in the role of Elam (ca. 4200-525 BCE), which broadly encompassed today’s southwest Iran and emerged as one of the military powerhouses of the ancient world thanks to its lowland and highland geo-political composition, access to the extensive resources of the Iranian plateau, control of important trade routes, and a military famed for its cutting-edge archery technology and the finesse of its archers. This study begins at the late 5th millennium BCE to investigate the rise and evolution of archery in Elamite warfare, drawing on snippets of "war correspondence" in local and foreign textual sources and the rich body of archaeological and iconographic evidence. It becomes clear throughout that archery was one of the cornerstones of Elamite warfare, its sovereignty, cultural identity, and longevity; and that Elam is crucial to our understanding of Near Eastern military history and the rise of the Achaemenid Persian empire. https://brill.com/display/title/70904
Mysticism and Ethics in Islam, 2021
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