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Pacing and Clinical Electrophysiology
The Anatomy and Physiology of the Sinoatrial Node-A Contemporary Review2010 •
Journal of Electrocardiology
Current aspects of the basic concepts of the electrophysiology of the sinoatrial node2019 •
Journal of Cardiovascular Electrophysiology
Sustained Inward Current and Pacemaker Activity of Mammalian Sinoatrial Node2002 •
2007 29th Annual International Conference of the IEEE Engineering in Medicine and Biology Society
Single Cells Isolated from Human Sinoatrial Node: Action Potentials and Numerical Reconstruction of Pacemaker Current2007 •
2018 Computing in Cardiology Conference (CinC)
The Mechanism Underlying Heart Rate and Pacemaking Activity Decline in Developing Sinoatrial Node of the Rabbit Heart2018 •
Diagnosis of heart disease and its treatment are based largely on our understanding of the electrophysiology of adult myocardium. However, the marked difference in the electrical action potential (AP)between neonatal and adult cardiac myocytes suggests a different set of molecular bases in neonatal myocytes, and therefore different treatment for new-borns. In this study we present a new mathematical model of sinoatrial node (SAN) cells of the neonatal rabbit, by modifying densities or kinetics of INa, ICaL, If, IKr, IKs, and INaCa in the adult rabbit SAN cell models developed by Zhang et al., based on available experimental data obtained from new-born rabbit SAN cells. The new model reproduced APs similar to experimental recordings from neonatal myocytes, with a faster pacemaking rate. Using the new model, we investigated how age-related changes in ionic currents modulate pacemaking AP morphology, demonstrating the model as a useful tool for testing the effects of drugs on neonatal ...
Experimental Physiology
Pacemaker shift in the rabbit sinoatrial node in response to vagal nerve stimulation2001 •
Circulation. Arrhythmia and electrophysiology
Distinguishing properties of cells from the myocardial sleeves of the pulmonary veins: a comparison of normal and abnormal pacemakers2008 •
A common source of arrhythmogenic spontaneous activity instigating atrial fibrillation is the myocardial tissue, or sleeves, at the base of the pulmonary veins. This study compared the properties of cells from the myocardial sleeves of the pulmonary veins (PV(m)) with cells from the normal cardiac pacemaker (the sinoatrial node) and regions of the atria. Our objective was to identify key features of these cells that predispose them to becoming the focus of cardiac arrhythmias. Single cells were isolated from samples of rabbit PV(m), central and peripheral sinoatrial node, crista terminalis, and left and right atria. Detailed morphology of cells was assessed and intracellular calcium concentrations measured with the use of Fluo-3. Cells from the PV(m) were smaller than atrial cells and showed large elevations in diastolic calcium during activation at physiological rates, a feature the PV(m) cells shared with cells from the sinoatrial node. Unstimulated spontaneous activity was observ...
Journal of Graphic Novels and Comics
[Comics studies] Politics of Extractivism, Grassroot justice and Crude2024 •
Actas del I Congreso de Hª de Andalucia. Andalucia Moderna. (Siglos XVI-XVII), t.I, Córdoba, 1978, 119-129.
Las rentas eclesiasticas en el Obispado de Malaga a mediados del siglo XVII1978 •
The Medieval Iberian Treasury in the Context of Cultural Interchange, edited by Therese Martin. Leiden: Brill
"The Scandinavian Container at San Isidoro, León, in the Context of Viking Art and Society"2020 •
International Journal of Risk and Contingency Management
Supply Chain Disruptions and Best-Practice Mitigation Strategies2012 •
International Journal of Production Research
Group decision support for product lifecycle management2020 •
2015 •
2024 •
Indo Global Journal of Pharmaceutical Sciences
Effect of Water Management on Methane Emission from a Rice Soils2017 •