A Refined Approach to Target the Molecular and Cellular Mechanisms in Pulmonary Fibrosis

Cells

Pulmonary fibrosis (PF) is a feared outcome of many pulmonary diseases which results in a reduction in lung compliance and capacity. The development of PF is relatively rare, but it can occur secondary to viral pneumonia, especially COVID-19 infection. While COVID-19 infection and its complications are still under investigation, we can look at a similar outbreak in the past to gain better insight as to the expected long-term outcomes of COVID-19 patient lung function. In the current article, we review the literature relative to PF via PubMed. We also performed a literature search for COVID-related pathological changes in the lungs. Finally, the paper was reviewed and summarized based on the studies’ integrity, relative, or power calculations. This article provides a narrative review that endeavors to elucidate the current understanding of the pathophysiological mechanisms underlying PF and therapeutic strategies. We also discussed the potential for preventing progression to the fibr...

Frontiers in Medicine, 2020

After decades of research, two therapies for chronic fibrotic lung disease are now approved by the FDA, with dozens more anti-fibrotic therapies in the pipeline. A great deal of enthusiasm has been generated for the use of these drugs, which are by no means curative but clearly have a favorable impact on lung function decline over time. Amidst a flurry of newly developed and repurposed drugs to treat the coronavirus disease 2019 (COVID-19) and its accompanying acute respiratory distress syndrome (ARDS), few have emerged as effective. Historically, survivors of severe viral pneumonia and related acute lung injury with ARDS often have near full recovery of lung function. While the pathological findings of the lungs of patients with COVID-19 can be diverse, current reports have shown significant lung fibrosis predominantly in autopsy studies. There is growing enthusiasm to study anti-fibrotic therapy for inevitable lung fibrosis, and clinical trials are underway using currently FDA-app...

Journal of Clinical Medicine

In December 2019, a novel coronavirus, SARS-CoV-2, appeared, causing a wide range of symptoms, mainly respiratory infection. In March 2020, the World Health Organization (WHO) declared Coronavirus Disease 2019 (COVID-19) a pandemic, therefore the efforts of scientists around the world are focused on finding the right treatment and vaccine for the novel disease. COVID-19 has spread rapidly over several months, affecting patients across all age groups and geographic areas. The disease has a diverse course; patients may range from asymptomatic to those with respiratory failure, complicated by acute respiratory distress syndrome (ARDS). One possible complication of pulmonary involvement in COVID-19 is pulmonary fibrosis, which leads to chronic breathing difficulties, long-term disability and affects patients’ quality of life. There are no specific mechanisms that lead to this phenomenon in COVID-19, but some information arises from previous severe acute respiratory syndrome (SARS) or Mi...

Cureus, 2022

Respiratory Medicine: X, 2020

Feminist Tahayyül, 2024

Bu makale 2000’lerden bu yana gelişen çoklutürler etnografisine temel oluşturan feminist perspektifi incelemektedir. Çoklutürler etnografisi yaşam ağını izlerken yalnızca insan deneyimlerini değil insan olmayanların yaşantılarını da kültür, toplum ve doğa kurucu öğeler olarak ele alan bir araştırma ve yazma yöntemidir. İnsan ve insandan fazla temasları, dolaşıklıkları ve birliktelikleri kapsamlı ekolojik çerçeveler içine yerleştirerek anlar. Yöntemin arka planında (1) dünyayı belli bir konumdan görmek, (2) doğa-kültür ayrımını reddetmek, (3) insan istisnacılığından vazgeçmek, (4) yaşamların dolaşık olduğunu anlamak ve (5) çoklutürler için bir dil geliştirmek gibi feminist tartışmalar bulunmaktadır. Bu tartışmalarla zenginleşen ve eleştirel karakterini kazanan çoklutürler etnografisi doğanın, bitkilerin, hayvanların ve insanların yaşamının, ölümünün, varlığının, yokluğunun, refahının birbirine bağlı olduğunu gösterebilme becerisine sahip bir yöntemdir. Bu bakımdan dünyayı farklı türlerin ekolojik bağlarıyla, temaslarıyla, çatışma ve uzlaşmalarıyla örülmüş bir yaşam ağı olarak anlamamızı sağlayabilir. Daha kapsayıcı alan araştırması pratikleri ve yaratıcı yazma biçimleri için imkân yaratabilir.

The American Historical Review, 2020

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