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Endotherapy in Biliopancreatic Diseases: ERCP Meets EUS
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AI-generated Abstract
Endoscopic retrograde cholangiopancreatography (ERCP) has transitioned from a purely diagnostic to a therapeutic procedure due to advancements in technology and techniques. The development of endoscopic ultrasound (EUS) has further enhanced the visualization of pancreatic conditions, overcoming limitations of earlier radiological methods. As procedures evolve, there is a rising concern regarding multidrug-resistant infections linked with ERCP, prompting manufacturers to innovate on cleaning protocols and device modifications to enhance safety and efficacy in gastrointestinal endoscopy.
Clinical Gastroenterology and Hepatology, 2020
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World Journal of Gastroenterology, 2009
AIM: To evaluate a new single-operator mini-endoscope, Spyglass®, for its performance, feasibility and safety in the management of pancreaticobiliary disease. METHODS: In a multicenter retrospective analysis of patients undergoing intraductal endoscopy, we evaluated 128 patients (71 men, mean age 57.6 years). Indications were therapeutic (TX) in 72 (56%) and diagnostic (DX) in 56 (44%). RESULTS: Peroral endoscopy was performed in 121 and percutaneous in seven. TX indications included CBD stones in 41, PD stones in six, and biliary strictures in 25. DX indications included abnormal LFT's in 15, abnormal imaging in 38 and cholangiocarcinoma staging in three. Visualization of the stone(s) was considered good in 31, fair in six, and poor in four. Advancement of the electrohydraulic lithotripsy probe was not possible in three patients and proper targeting of the lesion was partial in four patients. A holmium laser was used successfully in three patients. Ductal clearance was achieved in 37 patients after one procedure and in four patients after two procedures. Diagnosis of biliary strictures was modified in 20/29 and confirmed to be malignant in 10/23. Of the modified patients, no diagnosis was available in 17. Spyglass® demonstrated malignancy in 8/17 and non-malignancy in nine. Suspected pathology by imaging studies and abnormal LFT's was modified in 43/63 (66%). Staging of cholangiocarcinoma demonstrated multicentric cholangiocarcinoma in 2/3. There was no morbidity associated with the use of Spyglass®. CONCLUSION: Spyglass Spyscope® is a first generation, single operator miniature endoscope that can evaluate and treat various biliary and pancreatic tract diseases.
Journal of Clinical Medicine
Endoscopic retrograde cholangiopancreatography (ERCP) is considered to be the gold standard for diagnosis and interventions in biliopancreatic diseases. However, ERCP in patients with surgically altered anatomy (SAA) appears to be more difficult compared to cases with normal anatomy. Since the production of a balloon enteroscope (BE) for small intestine disorders, BE had also been used for biliopancreatic diseases in patients with SAA. Since the development of BE-assisted ERCP, the outcomes of procedures, such as stone extraction or drainage, have been reported as favorable. Recently, an interventional endoscopic ultrasound (EUS), such as EUS-guided biliary drainage (EUS-BD), has been developed and is available mainly for patients with difficult cases of ERCP. It is a good option for patients with SAA. The effectiveness of interventional EUS for patients with SAA has been reported. Both BE-assisted ERCP and interventional EUS have advantages and disadvantages. The choice of procedur...
Digestive Endoscopy, 2014
Background and Aim: In therapeutic endoscopic retrograde cholangiography (ERC) using a balloon-assisted enteroscope, each instrument insertion requires a long time, which prolongs the duration of the procedure. We conducted a retrospective single-center study to compare instrument insertability of a double-balloon enteroscope (DBE) with a 2.8-mm instrument channel diameter and a prototype short single-balloon enteroscope (SBE) with a 3.2-mm instrument channel diameter.
Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society, 2015
A limited number of endoscopic retrograde cholangiopancreatography (ERCP) accessories are compatible with the conventional single-balloon enteroscope (SBE) because of the latter's dimensions. The aim of the present study was to assess the utility of a prototype SBE that has a shorter working length and a wider channel than the conventional SBE. ERCP procedures carried out between January 2012 and July 2013 using the short SBE prototype were reconstructions such as Billroth II (B-II), post-gastrectomy with Roux-en-Y (RY-G), and post-choledochojejunostomy with Roux-en-Y (RY-CJ). We retrospectively analyzed the rate of reaching the blind end of the intestine, the diagnostic success rate, the interventional success rate, and the frequency of related complications. Twenty-seven ERCP procedures on 18 patients analyzed comprised two B-II, 15 RY-G, and 10 RY-CJ reconstructions. With a mean procedure time of 56 min (range 40-150 min), the rate of reaching the blind end, the diagnostic su...
Gastroenterología y Hepatología, 2016
Endoscopic ultrasound (EUS) and endoscopic retrograde cholangiopancreatography (ERCP) have much in common, including their main indications (biliopancreatic disorders), powerful therapeutic capacities and a steep learning curve. Over the years they have evolved from novel diagnostic procedures to interventional therapeutic techniques, but along different paths (different scopes or devices and endoscopists specializing exclusively in one or the other technique). However, EUS has gradually developed into a therapeutic technique that requires skills in the use of ERCP devices and stents, leading some ERCP specialists to explore the therapeutic potential of EUS. The corresponding literature, which has grown exponentially, includes recent experiments on combining the two techniques, which have gradually come to be used in routine care in a number of centers, with positive technical, clinical and financial outcomes. We review EUS and ERCP as individual or combined procedures for managing biliopancreatic disorders.
Gastrointestinal Endoscopy, 2000
Diagnostics
Endoscopic ultrasound (EUS) and endoscopic retrograde cholangiopancreatography (ERCP) are both crucial for the endoscopic management of biliopancreatic diseases: the combination of their diagnostic and therapeutic potential is useful in many clinical scenarios, such as indeterminate biliary stenosis, biliary stones, chronic pancreatitis and biliary and pancreatic malignancies. This natural and evident convergence between EUS and ERCP, which by 2006 we were calling the “Endoscopic ultrasonography retrograde colangiopancreatography (EURCP) concept”, has become a hot topic in the last years, together with the implementation of the therapeutic possibilities of EUS (from EUS-guided necrosectomy to gastro-entero anastomoses) and with the return of ERCP to its original diagnostic purpose thanks to ancillary techniques (extraductal ultrasound (EDUS), intraductal ultrasound (IDUS), cholangiopancreatoscopy with biopsies and probe-based confocal laser endomicroscopy (pCLE)). In this literary r...
Duodenoscopes
The standard endoscope for ERCP is the sideviewing duodenoscope, equipped with a tip with four-way angulation capability, a side-positioned air/water nozzle, an instrument channel, and a forceps elevator adjacent to the instrument channel outlet that allows fine linear instrument position changes facilitating cannulation and placement of various devices. Instrument channel diameter ranges from 2.2 to 5.5 mm. Duodenoscopes with 4.2 mm internal channel allowing to place biliary endoprostheses (10-11.5 Fr circumference) are the most used. Pediatric duodenoscopes with a 2.2 mm channel are available for examination in infants, while largest instrument channels (>5 mm) are found in so-called "mother/baby" scope system usedfor choledochoscopy and pancreatoscopy. However this system is difficult to manipulate and is now rarely used [1].
In certain situations where a traditional duodenoscope is not suitable (e.g., in patients with a Billroth II or a Roux-en-Y reconstruction), a forward-viewing endoscope may be tried instead [2]. Conventional endoscopes however provide a limited visualization of the ampullary region and are limited with respect to control of accessories during cannulation due to the absence of elevator. In recent years, infections due to multidrugresistant organisms (MDROs) have become a concern in health care, including in gastrointestinal endoscopy. Cases and serial outbreaks of MDROs infections associated with ERCP have been published from different countries from 2010 [3]. All the processes of cleaning, disinfection, and sterilization of duodenoscopes have been analyzed featuring different issues [4].
Major manufacturers developed tools to prevent infections such as detachable disposable distal cap. Post-procedure reprocessing is performed by detaching the disposable distal cap and cleaning and disinfecting the tip of the scope [5]. In addition, new adaptors that can be attached to the tip of the duodenoscope to inject a cleaning solution have been developed
Echoendoscopes
Endoscopic ultrasonography (EUS) combines endoscopy and intraluminal ultrasonography. The new electronic instruments are connected with processors with considerable digital capabilities. Therefore, the technical peculiarities of the endoscopes of the same brand (i.e., NBI, FICE, Hi-scan) are contemporary available with the technical features of the most modern ultrasounds equipment (Doppler, power Doppler, color Doppler, tissue harmonic echo [THE], contrast harmonic EUS [CH-EUS], elastography, etc.).
The instruments for endoscopic ultrasound evaluation can be divided in:
-radial echoendoscopes for diagnostic purposes, -linear echoendoscopes for diagnostic and interventional purposes.
Radial echoendoscopes consist of electronic radial-array transducers that orient the individual piezoelectric elements around the distal tip in a 360° radial array, producing an image in a plane perpendicular to the long axis of the echoendoscope that is very similar to the images provided by computed tomography. Radial-array echoendoscopes are used only for diagnostic EUS examinations because tissue sampling and therapeutic interventions are not possible due to the lack of visualization of needle or other devices track.
Linear echoendoscopes provide a plane of imaging parallel to the long axis of the scope with an image format that is similar to that obtained with transabdominal ultrasonography; only this type of probe allows real-time visualization of needles and other accessories introduced through the operative channel of the echoendoscope [6][7][8]. It allows to perform fine-needle aspiration or biopsy (FNA or FNAB), stent delivering, drainage, and locoregional treatments (i.e., celiac plexus block and neurolysis).
Three major manufacturers (Olympus, Pentax, Fujifilm) produce echoendoscopes.
Table 4 .