P3-108

S405 Poster P3:: Tuesday Posters causal nature of this relationship, and its implications for diagnosis and treatment of brain disease of old age. P3-107 WHITE MATTER INTEGRITY IN AGING— RELATIONSHIP TO VASCULAR RISK AND COGNITION Laura Fratiglioni1,2, Laura S. Hemmy3,4, Lars Bäckman1,2, Lars-Olof Wahlund5, Hui-Xin Wang1,2, Asa Livner1,2, Anders Frank5, Kelvin O. Lim3,4, 1Aging Research Center, Karolinska Institute, Stockholm, Sweden; 2Stockholm Gerontology Research Center, Stockholm, Sweden; 3University of Minnesota, Minneapolis, MN, USA; 4 GRECC, VAMC, Minneapolis, MN, USA; 5Neurotec, Karolinska Universitetssjukhuset, Huddinge, Sweden. Contact e-mail: kolim@umn.edu Background: Vascular risk factors contribute to the development of dementia and Alzheimer’s disease (AD). Objective: This study investigated the relationship between vascular risk factors, white matter integrity (WMI), and cognitive performance. Data were obtained from the Swedish National Study on Aging and Care-Kungsholmen (SNACK), a populationbased study of adults aged 60 years and above. Here, preliminary results are presented from a random sample of this cohort (n ⫽ 553) who underwent a structural MRI examination. Methods: Data from a randomly chosen sub-sample of those who were scanned are available at present (n⫽131). WMI was measured using diffusion tensor imaging (DTI). Three categories of factors were examined in relation to WMI: vascular factors (body mass index, B12/folate, and a composite index of vascular burden), clinical status (depression, subjective health, number of diseases, functional mobility, and balance), and genetic background (APOE status). Cognitive functioning was indexed using tests of processing speed, episodic memory, executive function and visuospatial function. Results/Conclusions: Multiple linear regression demonstrated that age was strongly related to mean diffusivity (MD) and fractional anisotropy (FA) in three identified regions (frontal, occipital and centrum semiovale white matter). The effect of age on WMI was independent of all demographic, vascular, clinical, and genetic factors assessed. Vascular burden and low levels of B12/folate were strongly related to MD in all regions and to FA in frontal areas, after adjustment for age, gender, education and body mass index. Among the cognitive tests, the measure of visuospatial function (mental rotation performance) independently contributed to alterations in MD and FA. In a sample of non-demented, relatively healthy older persons, age appears to be the strongest correlate of white matter alterations. Although independently related to WMI, vascular factors and clinical status did not modify this relationship. Follow-up data will be required to elucidate the mechanisms underlying the age-WMI relationship. P3-108 COGNITIVE DYSFUNCTION IN 14 PATIENTS WITH CAROTID STENOSIS: THE DETAILED NEUROPSYCHOLOGICAL FINDINGS AND BRAIN SPECT FINDINGS Jung Eun Kim1, SangYun Kim2, Soo-Joo Lee3, BoRam Lee3, Jong Eun Chun3, Byung Hee Lee3, 1Konyang University Hospital, Daejeon, Republic of Korea; 2Seoul National University Hospital, Bundang, Republic of Korea; 3Eulji University Hospital, Daejeon, Republic of Korea. Contact e-mail: je_kim220@hanmail.net Background & Objective(s): Impairment of cognitive function has been often reported in patients with carotid artery occlusive disease. Little is known, however, about the detailed pattern of cognitive dysfunction in these patients. We sought the distinct pattern of cognitive dysfunction in patients with extracranial carotid stenosis using comprehensive neuropsychological test. Methods: We analyzed the MR findings, the perfusion defect on SPECT, and the results of the neuropsychological test in 7 consecutive patients with angiographical-proven severe (70-99%) extracranial internal carotid artery (ICA) stenosis.Cognitions were examined by Seoul Neuropsychological Screening Battery and neglect battery. The degree of ICA stenosis was assessed by conventional angiography. The perfusion status was evaluated using brain Tc99m HMPAO SPECT. Results: The mean age of the patients varied between 62 and 81 years. The sex of patients was male for 8 patients and female for 4. The average length of education varied between 2 and 16 years. The lesion side of ICA stenosis was left for 6 patients and right for 6. Clinical manifestations were minor stroke for 6 patients, TIA for 5, and asymptomatic for 1. 8 patients had small infarcts in the periventricular or subcortical white matter, not cortex, on MRI and the other 4 had no ischemic lesion. On neuropsychological assessment, all patients had cognitive deficits in more than one domain of attention, frontal executive function, visual and verbal memory impairments or visuospatial dysfunction. The severe cognitive dysfunction in frontal executive domain and visuospatial one was found in most patients. The additional cognitive dysfunction in the other domains, such as memory impairment, attention deficit, or naming difficulty was seen in about 50% of the patients. These findings were seen even in the patient with TIA and ones with normal MRI finding. The perfusion SPECT revealed ipsilateral frontoparietal cortical hypoperfusion in all patients. Conclusions: The most prominent cognitive dysfunction was frontal executive dysfunction and visuospatial dysfunction in the patients with carotid stenosis. These dysfunctions may be associated with frontoparietal cortical dysfunction, which well correlated with hypoperfusion area on perfusion SPECT, but not with the findings on MRI. P3-109 LIPID PROFILE IN OLDER PATIENTS WITH VASCULAR DEMENTIA Veer Bahadur Singh1, Dinesh Kataria2, 1S.P. Medical College, Bikaner, India; 2Lady Harding Medical College, New Delhi, India. Contact e-mail: drvbsingh2001@yahoo.com Background: Some alterations of the lipoprotein profile have been associated with cerebrovascular disease. Recently, it has been suggested that cerebrovascular disease might play a role in the pathogenesis of vascular dementia (VD). Nevertheless, the possible association of dyslipidemias with VD is still a controversial issue. Methods: We investigated the lipoprotein profile in 100 older patients with vascular dementia (VD; n°: 60). The patients were compared with 54 community dwelling non-demented older controls. Results: After adjustment for functional status, blood sedimentation rate, and serum albumin levels, no differences in lipid profile emerged between the two groups, with the exception of HDL-C that was lower in VD compared with controls. Low HDL-C (⬍ 45 mg/dL) was associated with VD (O.R.: 6.52, C.I. 95%: 1.42-30.70 vs controls, and 4.31, C.I. 95%: 0.93-19.82 vs LOAD), after multivariate adjustment. No differences in plasma lipid levels emerged between the two groups. Conclusions: In this cross-sectional study low HDL-C levels are associated with VD, in a sample of older subjects. P3-110 NOTABLY HIGHER RATES OF BOTH VASCULAR RISK FACTORS AND VASCULAR DEMENTIA AMONG AFRICAN AMERICANS IN SOUTH CAROLINA: A PUBLIC HEALTH INTERVENTION OPPORTUNITY James N. Laditka1, Sarah B. Laditka2, Carol B. Cornman2, Candace N. Porter2, Dorothy R. Davis2, Jacobo Mintzer3, 1University of South Carolina, Columbia, SC, USA; 2University of South Carolina, Columbia, USA; 3Medical University of South Carolina, Charleston, SC, USA. Contact e-mail: jladitka@gwm.sc.edu Background: Vascular dementia (VaD) presents a notable prevention opportunity. The vascular damage associated with VaD may also be implicated in Alzheimer’s disease (AD). Diabetes, hypertension, obesity, and physical inactivity are likely VaD risk factors, all having behavioral components. South Carolina (SC) has 1.04 million residents age 55⫹, 66,000 85⫹. Most are non-Hispanic white (white) or African American (AA, 30%). The statewide population-based SC Alzheimer’s Disease Registry has reported notably high AA AD rates. Objective: To examine VaD risk