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2014, Molecular Cytogenetics
Acta Medica Medianae
Interindividual and Intraindividual Pharmacokinetic Variability of Tacrolimus Within the First Year After Renal Transplantation: Effect of CYP3A5 Gene PolymorphismPediatric Transplantation
Influence of CYP3A5 polymorphism on tacrolimus maintenance doses and serum levels after renal transplantation: Age dependency and pharmacological interaction with steroids2011 •
TAC, MMF and MP are used in pediatric kidney tx. The cytochrome P450 (CYP)3A5 enzyme appears to play a role in TAC metabolism. The aims of this study were to investigate CYP3A5 polymorphism's effect on TAC dosing and the age dependency of TAC dosing by testing blood concentrations, and the interaction between steroids and TAC during the first year after tx. Genomic DNA was extracted and amplified with specific primers. CYP3A5 alleles were confirmed by direct sequencing of PCR products on an automated AB13100 capillary sequencer. We studied 48 renal transplant patients (age at tx 12±0.5yr, 22 boys) receiving TAC, MMF, MP. Of these, 79% were CYP3A5*3/*3 (non-expressers homozygotes) and 21% were CYP3A5*1/*3 (expressers). TAC trough levels were 7.1±0.4ng/mL in CYP3A5*3/*3 patients and 6.5±0.7ng/mL in CYP3A5*1/*3 group (p=0.03). CYP3A5*1/*3 patients had lower levels of dose-adjusted TAC (36.7±5.8ng/mL/mg/kg/day) to achieve target blood concentration and required higher daily dose per weight (0.21±0.03mg/kg/day) than CYP3A5*3/*3 patients, 72.4±8.0ng/mL/mg/kg/day and 0.13±0.01mg/kg/day (p<0.001). Prepubertal patients with different CYP3A5 polymorphisms required significant higher TAC doses and achieved lower dose-normalized concentration compared with pubertal patients. Both TAC dose and adjusted-dose correlated with daily MP dose in CYP3A5*1*3 (r: 0.4, p<0.03 and r: 0.4, p<0.03) and in CYP3A5*3*3 (r: 0.6, p<0.01 and r: 0.47, p<0.001) patients. CYP3A5 polymorphism performed before tx could contribute to a better individualization of TAC therapy. The higher TAC dose in prepubertal patients and the pharmacological interactions between MP and TAC may not be fully explained by different CYP3A5 polymorphisms.
Journal of Pharmacogenomics & Pharmacoproteomics
Pharmacogenomics of CYP3A5 Polymorphism: Predicting Dose-adjusted Trough Levels of Tacrolimus in South Indian Renal Transplant Patients2016 •
2016 •
INTRODUCTION This study aimed to evaluate the effects of single nucleotide polymorphisms CYP3A4*1B and CYP3A5*3 on tacrolimus dose requirement among kidney transplant recipients. MATERIALS AND METHODS Blood levels of tacrolimus were measured using microparticle enzyme immunoassay. Genotyping analysis utilized specific polymerase chain reaction-restriction fragment length polymorphism methods for 137 kidney transplant recipients. RESULTS The median tacrolimus dose was significantly lower in the CYP3A4*1/*1 carriers (0.06 mg/kg/d; range, 0.007 mg/kg/d to 0.17 mg/kg/d) as compared to the CYP3A4*1B/*1B carriers (0.1 mg/kg/d; range, 0.03 mg/kg/d to 0.22 mg/kg/d; P = .001). Patients with at least 1 CYP3A5*1 wild-type allele required higher median doses of tacrolimus (median, 0.08 mg/kg/d; range, 0.03 mg/kg/d to 0.22 mg/kg/d) as compared to the CYP3A5*3 carriers (median, 0.05 mg/kg/d; range, 0.007 mg/kg/d to 0.17 mg/kg/d; P = .002). CONCLUSIONS This study showed that tacrolimus dose requi...
Toxicology and Applied Pharmacology
Dosing algorithm for Tacrolimus in Tunisian Kidney transplant patients: Effect of CYP 3A4*1B and CYP3A4*22 polymorphisms2020 •
Pharmacogenetics and Genomics
CYP3A5 genotype is not associated with a higher risk of acute rejection in tacrolimus-treated renal transplant recipients2008 •
Basic & Clinical Pharmacology & Toxicology
Influence of CYP3A5 Genetic Polymorphism on Tacrolimus Daily Dose Requirements and Acute Rejection in Renal Graft Recipients2008 •
Archives of Medical Research
CYP3A5 Polymorphism in Mexican Renal Transplant Recipients and its Association with Tacrolimus Dosing2012 •
2020 •
Linguistic analysis of a Medieval manuscript has revealed a hitherto unknown Romance language that was a hybrid of two linguistic cultures coming together on a Mediterranean island due to territorial conquest in the 15th century.
The World of Middle Kingdom III: Contributions on Archaeology, Art, Religion, and Written Sources
The Preservation of Monuments in the Written Sources of Dynastic Egypt between 2000 and 1550 BC2022 •
American Anthropologist
Review of Models and Methods in Regional Exchange (Fry ed.) by Gary Feinman (1981)1981 •
Social Sciences Studies Journal (SSSJournal) Dergisi, Cilt 4 Sayı : 17, Mayıs 2018
Akıllı ve Ekolojik Kentlerle Sürdürülebilir Kentsel Tasarım: "Arazi Bilgi Yönetimi Sistemi (ABYS)" ve “Mülkiyet ve İmar Hakki Aktarimi (MİHAM)"2018 •
Il vento di Eros. XIII Colloquio Internazionale Medioevo romanzo e orientale (Dipartimento di Scienze Umanistiche, Catania, 21-22 settembre 2023) Atti a cura di Anita Fabiani e Gaetano Lalomia Introduzione di Antonio Pioletti.
L’amore “vissuto” e l’amore raccontato: la finzione autoriale di protagonismo del Joufroi de Poitiers2024 •
Repensando la sociedad colonial. Perspectivas, abordajes y desafíos de los enfoques multidisciplinares – Perú y Nueva España, siglos XVI–XVIII
Open-Access-Publikation (CC BY-NC-ND 4.02023 •
Diritto delle organizzazioni internazionali
Diritto delle organizzazioni internazionali2024 •
2011 •
Acta Scientiarum. Animal Sciences
Efeitos da restrição energética para suínos na fase final de terminação sobre o desempenho, característica de carcaça e poluição ambiental2007 •
Revista de Gestão e Secretariado (Management and Administrative Professional Review)
Gestão arquivística e administração pública: a preservação e a segurança dos documentos arquivísticos digitaisBulletin of the World Health Organisation
Quality and comparison of antenatal care in public and private providers in the United Republic of Tanzania. Bull World Health OrganRome and The Guidebook Tradition
Appendix I: Must-See Monuments – the Colosseum in Guidebooks through the Centuries2019 •
World Neurosurgery
Highly Active Antiretroviral Therapy and Gamma Knife Radiosurgery for the Treatment of AIDS-Related Primary Central Nervous System Lymphoma: A Case Report2019 •
Anuario colombiano de Fenomenología nro XIV
Esencia de la técnica: solicitación y resolución del intelectual2022 •
Journal of Sohag Agriscience (JSAS) (Print)
Dissipation kinetics study of acetamiprid, metalaxyl-M and fenpyroximate in the ecosystem of tomato fruits under field and greenhouses conditions2022 •