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2015, Asian Journal of Pharmaceutical and Clinical Research
Current Opinion in Allergy & Clinical Immunology
Angioedema associated with nonsteroidal anti-inflammatory drugs2016 •
Allergology International
Recurrent Severe Angioedema Associated with Imidapril and Diclofenac2008 •
Background: Angioedema due to angiotensin-converting enzyme inhibitors (ACEIs) therapy occurs not infrequently and is sometimes associated with life-threatening conditions. Case Summary: A 59-year-old woman presented with recurrent angioedema of the tongue complicated by upper airway obstruction which required endotracheal intubation. Laboratory tests including complement levels were normal. ACEI-associated angioedema precipitated by NSAIDs was suspected. Her condition improved after discontinuation of imidapril and diclofenac without other specific treatment. Discussion: ACEIs, and in particular concomitant use with NSAIDs, should be avoided in patients with a history of angioedema because continuing administration tends to lead to more severe attacks.
International Journal of Research in Pharmaceutical Sciences
Ketorolac induced non allergic angioedema: A case report2020 •
Non- Steroidal anti-inflammatory drugs (NSAIDs) are among the most commonly prescribed category of drugs. NSAIDs are the main cause of allergic reactions both in adults and children. Hypersensitivity reactions due to NSAIDs involve 0.3% to 0.5% of the overall population. Among the different types of NSAIDs induced hypersensitivity reactions, urticaria and angioedema are the most common. Angioedema can be of two types, allergic(IgE) & Nonallergic( Non IgE) mediated. Allergic angioedema is immune mediated but non allergic angioedema mimic immune mediated allergic reaction without underlying evidence of immunological mechanism which can cause diagnostic difficulties for the clinician. Distinguishing immune-mediated and non-immune-mediated reactions can be difficult, so careful evaluation is needed. Pathomechanism of NSAIDs induced non allergic angioedema is based on cysteniyl leukotrienes and bradykinin pathway in which NSAIDs block cyclo oxygenase pathway and directs the lipoxygenase ...
Indian Journal of Pharmacy Practice
A Case Report on Diclofenac Induced Chronic Kidney DiseaseClinical Drug Investigation
Retrospective Evaluation of Adverse??Drug Reactions Induced??by??Nonsteroidal Anti-Inflammatory Drugs2007 •
Diclofenac is a member of nonsteroidal anti-inflammatory drugs. In Turkey, ıt is often used as a analgesic. Diclofenac may very occasionally lead to spontaneous extensive ecchymosis and hematoma despite a normal coagulation parameters. In this paper, we report one patient who presented with spontaneous extensive ecchymosis and was diagnosed with a hematoma in the anterior chest wall associated with diclofenac use despite normal coagulation parameters. In countries like Turkey where NSAID are used extensively, drug history should be questioned in patients presenting with spontaneous bleeding and have normal coagulation parameters by physicians.
Hereditary angioedema (HAE) is a rare disease with different frequencies for different populations. Etiologically the disease is associated with congenital immune deficiencies in the complement system. It is also known that in the pathogenesis of type I HAE leading position occupies the quantitative deficiency of C1-esterase inhibitor (C1-INH). Under the influence of various inducing factors, most commonly injuries, invasive procedures, giving birth, stress and others, is triggered a cascade of reactions leading to the activation of the kinin system, the end result of which is the clinical manifestation of angioedema. Drug-induced edemas were also described in the literature, but their pathogenesis differs from that of HAE. In most cases, behind the induced by taking medication swelling, stand allergic mechanisms. Cases of angioedema induced by other factors and developt by other mechanisms were also described. For participants in the etiology and pathogenesis of angioedema adopt a number of other factors such as irritant, physical, toxic, neuro-reflex agents. In our review of the literature, however, the cases with induced by an opioid analgesic angioedema in patients with proven HAE type I are relatively rare. Therefore we think that the presented clinical case will enrich the knowledge of the etiology and pathogenesis of angioedema and attract the interest of different clinical specialists - allergists, immunologists, ophthalmologists, dermatologists, toxicologists and others.
International Journal of Basic & Clinical Pharmacology
Angioedema caused by over the counter use of dicyclomine hydrochloride and paracetamol fixed dose combination in a child: a case report2018 •
Authors describe a case of angioedema in a male child due to over-the-counter (OTC) use of fixed dose combination (FDC) of Tab. dicyclomine hydrochloride (20mg) and paracetamol (500mg) for abdominal pain. Use of OTC drugs in children without a doctor’s suggestion can lead to unnecessary medication use and is not free of risks. Here, there is a probable causal relationship between the suspected drug and angioedema according to WHO-UMC criteria for Causality Assessment. This case was also reported to the Pharmacovigilance Programme of India (PvPI) through PvPI ADR android application.
The Crusades Against the Hussites in Bohemia (1419–1436), in: Crusading Against Christians in the Middle Ages, ed. Mike Carr, Nikolaos Chrissis and Gianluca Raccagni
The crusades against the Hussites in Bohemia (1419–1436)2024 •
2018 •
Research on Psalter Catenae. Current Trends and and Recent Developments (ed. by C. Bandt & R. Ceulemans)
Fragments of Works or Working with Fragments? Rethinking the Composition of the Catena Monacensis on Romans (CPG C161)2024 •
Kréolistika: Revue des mondes créoles
Creole in Education in Trinidad & Tobago2021 •
Pacific Affairs, Vol. 83, No. 4
Review of John Holt: Spirits of the Place (2010)2010 •
Techos verdes y jardines verticales
Techos verdes y jardines verticales2020 •
2017 •
2017 •
American Journal of Public Health Research
Study of IYCF Indicators on Practices and Knowledge of Mothers in Rural AreasProceedings of the Human Factors and Ergonomics Society Annual Meeting
Multi-Touch: A New Tactile 2-D Gesture Interface for Human-Computer Interaction2001 •
arXiv (Cornell University)
Spectral Factorization of Rank-Deficient Rational Densities2022 •
Annals of the New York Academy of Sciences
Cognitive Alterations as Markers of Vulnerability to Schizophrenia1992 •
International Conference on Gender Research
Emotions as a lasting leadership learning in high-potential female students