- Bengaluru, Karnataka, India
Background: Anxiety disorders remain the commonest mental disorder in general population. Both these disorders are common in pregnant women and postpartum period and are underdiagnosed. There is a paucity of research on mental disorders... more
Background: Anxiety disorders remain the commonest mental disorder in general population. Both these disorders are common in pregnant women and postpartum period and are underdiagnosed. There is a paucity of research on mental disorders and their risk factors among women during postnatal period in India. This study aims to estimate the incidence of generalised anxiety disorder (GAD) and depression and explore the common associated factors among postnatal women in India. Aim: The present study aims to study the incidence and risk factors of generalised anxiety disorders among mothers attending the outpatient department clinic (OPD) for vaccination of their children or gynaecology OPD for follow up. Methods: Total of 180 women of postpartum period, up to 6 months, was randomly selected and assessed using self-report questionnaire GAD-7 for GAD. General demographic details were obtained via a revalidated proforma. Incidence and risk factors for both these mental disorders were assessed...
Research Interests:
Vancomycin is an antibiotic with rapid resurgence during past few years. The emergence of Methicillin Resistant Staphyloccus Aureus (MRSA) and growing concern about enterococcal diseases has dramatically sparked the uprising of... more
Vancomycin is an antibiotic with rapid resurgence during past few years. The emergence of Methicillin Resistant Staphyloccus Aureus (MRSA) and growing concern about enterococcal diseases has dramatically sparked the uprising of Vancomycin. It is a glycopeptide antibiotic active against gram positive organism. Vancomycin is associated with two types of hypersensitivity reactions red man syndrome and anaphylaxis. Red Man syndrome is more common type infusion related hypersensitivity reaction. It is more common with rapid infusion of Vancomycin. Red Man Syndrome is usually presents with pruritus, erythematous rash commonly involving head, neck and upper part of body and less frequently with chest pain, hypotension and cardiovascular collapse. Discontinuation of antibiotic and treatment with antihistaminic can abort most of the reactions. Herewith, presenting a case report of Vancomycin induced Red Man Syndrome in premature low-birth weight neonate.
Background: Very few studies have been done to assess perceptions of teachers and considering diverse views about teaching methodologies, this study was carried out with objectives to assess preferences of medical teachers for the use of... more
Background: Very few studies have been done to assess perceptions of teachers and considering diverse views about teaching methodologies, this study was carried out with objectives to assess preferences of medical teachers for the use of audiovisual aids in lecture delivery as well as practices of medical teachers regarding use of audiovisual aids.
Plan: The present study was carried out to evaluate anticonvulsant activity of Nigella sativa oil in Pentylenetetrazol (PTZ) and Maximal electroshock (MES) induced seizures in mice. Methodology: The anticonvulsant activity of Nigella... more
Plan: The present study was carried out to evaluate anticonvulsant activity of Nigella sativa oil in Pentylenetetrazol (PTZ) and Maximal electroshock (MES) induced seizures in mice. Methodology: The anticonvulsant activity of Nigella sativa oil at dose of 10 mg/kg/p.o. was evaluated in mice by using electroshock and PTZ seizure methods. The standard was taken as Phenytoin for electroshock method and Diazepam for PTZ method. Outcome: In PTZ model Nigella sativa showed statistically significant protection in increasing the latency of convulsions (p value 0.030). While in MES model though there was decrease in the duration of tonic hind limb extension but it was not statistically significant. Conclusions: Nigella sativa has shown anticonvulsant activity in PTZ model, which is suggestive of its potential benefit in
Research Interests:
Objective: The objective was to evaluate analgesic activity of candesartan in graded dose in tail flick method in rats and acetic acid-induced writhing in mice. Methods: Wistar Albino rats of either sex weighing 200-250 g or Swiss Albino... more
Objective: The objective was to evaluate analgesic activity of candesartan in graded dose in tail flick method in rats and acetic acid-induced writhing in mice. Methods: Wistar Albino rats of either sex weighing 200-250 g or Swiss Albino mice of either sex weighing 20-25 g. Analgesic activity of candesartan (5 mg/kg, 10 mg/kg, 15 mg/kg.) was evaluated in graded dose and compared with tramadol (10 mg/kg) and aspirin (100 mg/kg) using tail flick response method and acetic acid-induced writhing of analgesia. Study was conducted after approval from the Institutional Animal Ethics Committee, which is an approved body by Committee for the Purpose of Control and Supervision of Experiments on Animals letter no. 78 dated October 18, 2012. Results: In the present study, oral administration of candesartan showed analgesic activity at high dose compared to the control and less analgesic activity as compared to the standard in analgesic methods. In tail-flick method, after 30-90 minutes of drug ...
Background: Hyperbilirubinemia is one of the common problems in neonates. The transcutaneous bilirubin (TCB) measurement is non-invasive, easy and rapid not requiring expertise and manpower. Fewer studies have been carried out to whether... more
Background: Hyperbilirubinemia is one of the common problems in neonates. The transcutaneous bilirubin (TCB) measurement is non-invasive, easy and rapid not requiring expertise and manpower. Fewer studies have been carried out to whether newer TCB measurements can correlate with serum bilirubin measurements using newer generation of transcutaneous bilirubinometer in our region.Methods: An observational cross-sectional study to compare serum and transcutaneous bilirubin measurements in newborns admitted to a neonatal intensive care unit, conducted from December 2015 to November 2017. Blood samples were obtained from neonates collected from venous sample into plain bulb and sent for analysis. For transcutaneous bilirubin measurement, the reading from forehead and sternum were taken using bilirubinometer and an average reading was taken for comparison.Results: Total 172 neonates were admitted during study period and enrolled in the study. It was observed that out of 172 patients, studi...
Research Interests:
Research Interests:
Background: Drug utilization pattern studies helps to screen, assess and propose appropriate modifications in prescription practices, this would help to make patient care rational and cost effective. Study was intended to analyse the drug... more
Background: Drug utilization pattern studies helps to screen, assess and propose appropriate modifications in prescription practices, this would help to make patient care rational and cost effective. Study was intended to analyse the drug prescribing pattern for treatment of Ischemic heart disease using WHO indicators.Methods: This is a cross sectional observational study conducted on ischemic heart disease patients admitted at inpatient department of medicine in a tertiary care teaching hospital. The study consisted of analysis of drug utilization pattern of prescribed drugs.Results: IHD was more commonly seen in males (70.06%) than females (29.94%). IHD was most commonly seen in patients of age group of 61-70 year. Drugs prescribed to patients belong to various therapeutic classes ranging from anti-platelets, anticoagulants, anti-anginal, antithrombin, thrombolytic, hypolipidemics. The most commonly prescribed therapeutic class of drugs was antiplatelet (86.26%) followed by hypoli...
Research Interests:
Background: Inappropriate drug prescribing is a global problem affecting the healthcare system. Aim and objective of the study was to study the drug utilization pattern in geriatric patient at rural tertiary care hospital.Methods: This... more
Background: Inappropriate drug prescribing is a global problem affecting the healthcare system. Aim and objective of the study was to study the drug utilization pattern in geriatric patient at rural tertiary care hospital.Methods: This was a cross- sectional observational study involving 600 geriatric outpatient. This study was carried out from Nov 2015 to May 2016. The data were collected using predesigned proforma specially designed for this purpose. Relevant information was obtained by analyzing prescription for World Health Organization (WHO) core drug indicators.Results: Total number 600 prescriptions analyzed at the end of six months were from general medicine department. The mean age of the patients was 63.9 years in which male (61.33%) outnumber the female. Total number 2598 drugs were prescribed to 600 patients for different diseases. The mean number of drugs per prescription were 4.33, drugs were prescribed by generic name 26.42%. drugs were prescribed from WHO essential d...
Research Interests:
Research Interests:
Objective: To observe a prescription pattern in elderly patients attending outpatient department (OPD) and evaluating prescriptions according to theWorld Health Organization (WHO) prescription indicators.Methods: A cross-sectional... more
Objective: To observe a prescription pattern in elderly patients attending outpatient department (OPD) and evaluating prescriptions according to theWorld Health Organization (WHO) prescription indicators.Methods: A cross-sectional observational study was conducted from July to September 2015. Patients of either gender, age 60 years or more, attending OPD in tertiary care hospital were included in the study. Prescriptions of medical practitioners were collected and evaluated for demographic data and the WHO drug prescribing indicators.Results: A total of 600 patients were enrolled in the study. The majority of the patients were in the age group 60-69 years (66.33%) with male preponderance (61%). The average number of drugs per prescription was 3.41. Out of 2045 drugs prescribed, 1261 drugs (61.66%) were prescribed by their generic name and 784 drugs (38.33%) were prescribed by their brand name. 1700 drugs (83.12%) prescribed were from the WHOs essential medicines list 2015. Total enc...
Research Interests:
Research Interests:
Background: Drug utilization studies can provide insights into a pattern, quality, determinants and outcomes of drug use. COPD is one of the leading causes of death among Indian population and there is a lack of drug utilization studies... more
Background: Drug utilization studies can provide insights into a pattern, quality, determinants and outcomes of drug use. COPD is one of the leading causes of death among Indian population and there is a lack of drug utilization studies in this field.Methods: A prospective, observational study was conducted among the patients admitted in inpatient department of medicine ward of Tertiary care hospital. Data has collected from COPD patients admission records. Parameters like demographic profile, common associated diseases, WHO core drug indicators and commonly prescribed drugs were assessed from the prescriptions.Results: A total 284 inpatient records were scrutinized. Out of 284 patients, 66.19% were male and 33.80% were female. Average numbers of drugs per prescription were 7. Mean age was 66.9 years. Antimicrobials (88.7%) were most commonly prescribed drugs followed by inhaled bronchodilators (84.5%).Conclusions: Study data highlights that average numbers of drugs prescribed were ...
Research Interests:
Research Interests:
Research Interests:
Research Interests:
Research Interests:
Research Interests:
Background: Drugs commonly used in modern medicine for suppression of pain and fever provide only symptomatic relief, and long-term use of these drugs is associated with serious adverse effects. Recently, some evidences suggest that... more
Background: Drugs commonly used in modern medicine for suppression of pain and fever provide only symptomatic relief, and long-term use of these drugs is associated with serious adverse effects. Recently, some evidences suggest that Nigella sativa inhibit eicosanoid generation in leukocytes and lipid peroxidation. They are reported to inhibit both cyclooxygenase and 5-lipooxygenase pathways of arachidonic acid metabolism (Houghton et al. Planta Med 1995;61:336). Aims and Objectives: To investigate the analgesic and antipyretic activity of N. sativa seed fixed oil and compare it with control and aspirin. Materials and Methods: Albino Wistar rats of either sex weighing 180200 g and Swiss mice weighing 2530 g were used. The study was conducted after approval from the Institutional Animal Ethics Committee. The tail flick method in rats described by DAmour and Smith and acetic acid-induced writhing in mice were used for evaluation of analgesic activity and bakers yeast-induced pyrexia method was used to evaluate antipyretic activity. Result: In tail flick method of analgesia, N. sativa showed analgesic activity, which was comparable with aspirin. In acetic acid-induced writhing model of analgesia, the action of N. sativa was significantly greater than the control group, and it was comparable with aspirin. In bakers yeast-induced pyrexia method, N. sativa group did not show any significant reduction in the rectal temperature at any hour interval. The changes in the rectal temperature in N. sativa group were comparable with control group (p > 0.05). Conclusion: Nigella sativa fixed oil has significant analgesic activity in both tail flick and acetic acid-induced method of analgesia. But, it does not have any significant antipyretic activity in bakers yeast-induced pyrexia method.
Research Interests:
Research Interests:
Objective: Evaluation of knowledge, attitude and practice of healthcare providers about Medication errors. Method : It was a KAP survey conducted with the help of specially designed and pre-validated questionnaire. Doctors’, nurses’ and... more
Objective: Evaluation of knowledge, attitude and practice of healthcare providers about Medication errors. Method : It was a KAP survey conducted with the help of specially designed and pre-validated questionnaire. Doctors’, nurses’ and pharmacists’ awareness and perception about Medication errors were assessed. KAP survey questionnaire was analyzed and their question-wise percentage value was calculated. Data was analysed with One-way ANOVA followed by Dunnets post-hoc test and descriptive statistics were applied whenever necessary. Results: Response rate amongst healthcare providers was satisfactory. Doctors’ knowledge and practice were significantly higher compared to the nurses and the pharmacists. Their perception when analysed, revealed that most of the participants consider medication error as an important problem which can be prevented. There is a difference of opinions as regards to the liability for legal punishment to the personnels responsible for such incidences, thus considering it as a crime. Conclusion: There is awareness regarding Medication errors, yet certain circumstances which significantly contribute in occurrence of these events need to be overcome. Regardless of the availability of few solutions, as this area of practice is least approached, further research is warranted in various interventions to deal with the same. Key words: Awareness, Doctors, Medication errors, Nurses, Pharmacists.
Research Interests:
Research Interests:
Research Interests:
Research Interests:
Research Interests:
Research Interests:
Background: Snake bite is a major problem in rural India. The lack of universal consensus toward the dose of ASV to be used and dose-related adverse effects have been long-standing issues in the snake bite management protocols. Objective:... more
Background: Snake bite is a major problem in rural India. The lack of universal consensus toward the dose of ASV to be used and dose-related adverse effects have been long-standing issues in the snake bite management protocols. Objective: To observe the effects of dose of anti-snake venom (ASV) on outcomes and adverse effects in snake bite cases, in a rural tertiary care hospital in Maharashtra, India. Materials and Methods: A cross-sectional observational study was carried out in the medicine intensive care unit (ICU) of SRTR GMC, Ambajogai by scrutinizing the prescriptions of 70 snake bite patients admitted to the ICU during the study period of 3 months. Data were analyzed using descriptive statistics and Microsoft Excel 2007. Statistical analysis was carried out using the Fisher’s Exact test. Result: Acute kidney injury developed in 6 (20%) and 9 (22.5%) patients, neuroparalysis requiring ventilator support developed in 4 (13.3%) and 6 (15%) patients, hospital stay duration was 1.36 and 2.92 days and the mortality rate was 3.3% versus 5%, in patients given low and high dose of ASV, respectively. But, the occurrence of adverse effects to ASV was significantly less with low dose of ASV. Conclusion: Results were found to be comparable in terms of treatment outcomes. So, low doses of ASV can be utilized to optimize usage and minimize its adverse effects.