Additional file 2 of Estrogen-related receptor alpha directly binds to p53 and cooperatively controls colon cancer growth through the regulation of mitochondrial biogenesis and function

Additional file 2: Figure S2. Related to Fig. 1h. A The p53 CTD (Lys370 – Asp391) in green is superposed on the box3-peptide of PGC1α (Gln203 – Asp224) shown in red. The ERRα LBD is shown in yellow. B The box3-peptide of PGC1α is removed from the complex shown in (A). C Zoomed in the interface between the p53 CTD and the box3-peptide of PGC1α showing three potential non-bonding interactions. D Electrostatic surface representation of ERRα at the binding interface with p53, where the red color indicating negatively charged region, blue color being the positively charged region, and the in-between gray color being the hydrophobic region. Here, the hydrophobic residue Leu383 from p53 is trapped within a hydrophobic pocket formed by several hydrophobic residues of ERRα at the binding interface. E Sequence alignment between the ERα LBD (Met192-Tyr389) and the ERRα LBD (Val225-Tyr414). F Superposition of the ERα LBD (in orange) and the ERRα LBD (in green). G Sequence alignment between the ...