Antiseptic
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To investigate the prevalence, duration, and etiology of bacteremia following dental extractions performed after a single administration of chlorhexidine mouthwash. A randomized, controlled trial performed in a university hospital. A... more
To investigate the prevalence, duration, and etiology of bacteremia following dental extractions performed after a single administration of chlorhexidine mouthwash.
A randomized, controlled trial performed in a university hospital.
A series of 106 patients with mental and behavioral disabilities who underwent dental extractions under general anesthesia were randomly assigned to a control group or chlorhexidine group. The exclusion criteria applied were use of antibiotics in the previous 3 months, use of oral antiseptics, any type of congenital or acquired immunodeficiency, and disease that predisposes the patient to infections or bleeding. The chlorhexidine group had 0.2% chlorhexidine mouthwash administered for 30 seconds before any dental manipulation. Blood samples were collected at baseline, 30 seconds, 15 minutes, and 1 hour after the dental extractions. Subculture and further identification of the isolated bacteria were performed by conventional microbiological techniques.
The prevalence of bacteremia after dental extraction in the control and chlorhexidine groups were 96% and 79%, respectively, at 30 seconds (P=.008), 64% and 30% at 15 minutes (P<.001), and 20% and 2% at 1 hour (P=.005). The most frequently identified bacteria were Streptococcus species in both the control and chlorhexidine groups (64% and 68%, respectively), particularly viridans group streptococci.
We recommend the routine use of a 0.2% chlorhexidine mouthwash before dental extractions to reduce the risk of postextraction bacteremia.
A randomized, controlled trial performed in a university hospital.
A series of 106 patients with mental and behavioral disabilities who underwent dental extractions under general anesthesia were randomly assigned to a control group or chlorhexidine group. The exclusion criteria applied were use of antibiotics in the previous 3 months, use of oral antiseptics, any type of congenital or acquired immunodeficiency, and disease that predisposes the patient to infections or bleeding. The chlorhexidine group had 0.2% chlorhexidine mouthwash administered for 30 seconds before any dental manipulation. Blood samples were collected at baseline, 30 seconds, 15 minutes, and 1 hour after the dental extractions. Subculture and further identification of the isolated bacteria were performed by conventional microbiological techniques.
The prevalence of bacteremia after dental extraction in the control and chlorhexidine groups were 96% and 79%, respectively, at 30 seconds (P=.008), 64% and 30% at 15 minutes (P<.001), and 20% and 2% at 1 hour (P=.005). The most frequently identified bacteria were Streptococcus species in both the control and chlorhexidine groups (64% and 68%, respectively), particularly viridans group streptococci.
We recommend the routine use of a 0.2% chlorhexidine mouthwash before dental extractions to reduce the risk of postextraction bacteremia.
- by Inmaculada Tomas and +1
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- Dentistry, Dental Research, Oral Biology, Oral health
Issue of the treatment of mixed genital infections and prevention of reproductive health disorders caused by them has not lost medical and social significance, which is associated with a high frequency of mixed infections, absence of... more
Issue of the treatment of mixed genital infections and prevention of reproductive health disorders caused by them has not lost medical and social significance, which is associated with a high frequency of mixed infections, absence of pathognomonic clinical manifestations, and with a constantly significant frequency of sexually transmitted infections (chlamydia, genital herpes, trichomoniasis, etc.). It should be controlled and rationally limited antibiotics use in connection with a sharp increase in microorganisms’ resistance. At the same time proven antiseptics which are used to reduce the infection risk or to treat vaginal infections do not contribute to the formation of resistant pathogens.
The purpose of this literature review was to analyze publications about modern antiseptic octenidine dihydrochloride for mucous membranes, skin and wounds and the prospects for it use in obstetric and gynecological practice.
Octenidine dihydrochloride (octenidine) was synthesized as a multi-functional antiseptic for skin, mucous membranes and wounds. Today octenidine is an active antiseptic with a wide scope of use and is an alternative to chlorhexidine, povidone iodine, triclosan, etc. Octenidine is a cationic antiseptic of a new chemical group (derivatives of bispyridinamine), is a safe and effective antimicrobial agent with a high level and spectrum of antimicrobial activity. The antiseptic activity of octenidine is achieved within 30 seconds, it is chemically resistant, has proven low toxicity to humans and the environment and high clinical efficacy, does not cause the pathogen resistance, is approved for use from the second trimester in pregnancy and during breastfeeding. Octenidine use with or without combinations should be considered as an integral part of the standard therapy for various types of vaginitis and bacterial vaginosis. Octenidine can become a promising agent for therapeutic indications in gynecology in future, since it surpasses povidone iodine, polyhexanide and chlorhexidine in the efficiency of microorganisms’ eradication from the mucous membranes.
The purpose of this literature review was to analyze publications about modern antiseptic octenidine dihydrochloride for mucous membranes, skin and wounds and the prospects for it use in obstetric and gynecological practice.
Octenidine dihydrochloride (octenidine) was synthesized as a multi-functional antiseptic for skin, mucous membranes and wounds. Today octenidine is an active antiseptic with a wide scope of use and is an alternative to chlorhexidine, povidone iodine, triclosan, etc. Octenidine is a cationic antiseptic of a new chemical group (derivatives of bispyridinamine), is a safe and effective antimicrobial agent with a high level and spectrum of antimicrobial activity. The antiseptic activity of octenidine is achieved within 30 seconds, it is chemically resistant, has proven low toxicity to humans and the environment and high clinical efficacy, does not cause the pathogen resistance, is approved for use from the second trimester in pregnancy and during breastfeeding. Octenidine use with or without combinations should be considered as an integral part of the standard therapy for various types of vaginitis and bacterial vaginosis. Octenidine can become a promising agent for therapeutic indications in gynecology in future, since it surpasses povidone iodine, polyhexanide and chlorhexidine in the efficiency of microorganisms’ eradication from the mucous membranes.