Congenital heart defects represent the most common malformation at birth, occurring also in ∼50% of individuals with Down syndrome. Congenital heart defects are thought to have multifactorial etiology, but the main causes are largely... more
Congenital heart defects represent the most common malformation at birth, occurring also in ∼50% of individuals with Down syndrome. Congenital heart defects are thought to have multifactorial etiology, but the main causes are largely unknown. We have explored the global methylation profile of fetal heart DNA in comparison to blood DNA from control subjects: an absolute correlation with the type of tissue was detected. Pathway analysis revealed a significant enrichment of differential methylation at genes related to muscle contraction and cardiomyopathies in the developing heart DNA. We have also searched for abnormal methylation profiles on developing heart-tissue DNA of syndromic and non-syndromic congenital heart defects. On average, 3 regions with aberrant methylation were detected per sample and 18 regions were found differentially methylated between groups. Several epimutations were detected in candidate genes involved in growth regulation, apoptosis and folate pathway. A likel...
OBJECTIVE: To evaluate the role of pharmacist in treatment of the development of diabetes mellitus along with progression of long term complication of diabetes mellitus (insulin-dependent) along with coronary heart disease... more
OBJECTIVE: To evaluate the role of pharmacist in treatment of the development of diabetes mellitus along with progression of long term complication of diabetes mellitus (insulin-dependent) along with coronary heart disease BACKGROUND:Diabetes mellitus is a metabolic disorder in the endocrine system.In patients with diabetes, a high priority must be given to modification of the major risk factors for coronary heart disease (CHD). There is growing evidence that control of these risk factors will reduce the likelihood of developing CHD and its complications in patients with diabetes METHODOLOGY: We identified 61 white patients under 65 years of age with insulin-dependent diabetes who had Coronary heart disease, and then matched them with 61 diabetic patients without Coronary heart disease.We determined the prevalence of cardiovascular disease in the parents of these patients with use of information obtained from death certificates or questionnaire for cardiovascular disease. RESULTS: The diabetic patients with coronary heart disease had higher serum creatinine concentrations and mean arterial pressure than the diabetic patients without coronary heart disease. They also had a higher prevalence of anti hypertensive treatment (79 percent vs. 10 percent, P<0.001) and cardiovascular disease (39 percent vs. 7 percent, P<0.001). There were similar numbers of smokers in the two groups: 11 in the group with coronary heart disease and 15 in the group without coronary heart disease (18 percent vs. 25 percent). When the mortality and morbidity were combined, the total prevalence of cardiovascular disease in the parents of the patients with coronary heart disease was more than twice that in the parents of patients without coronary heart disease (31 percent vs. 14 percent, P<0.01) (Fig. 2), yielding an age-adjusted and sex-adjusted relative risk of 2.9 (95 percent confidence interval, 1.5 to 5.5; P<0.001). CONCLUSION: Among patients with insulin-dependent diabetes, a parental history of cardiovascular disease is significantly associated with the development of cardiovascular disease. The rates of ascertainment of information were 96 percent (n = 117) for the parents of diabetic patients with Coronary heart disease and 95 percent (n = 116) for the parents of patients without Coronary heart disease. Cardiovascular disease was more often a direct cause of death among the parents of diabetic patients with Coronary heart disease (40 percent vs. 22 percent, P<0.03)
The study of ACE gene I/D polymorphism has been carried out in elderly, senile and long-liver patients with coronary heart disease (CHD) taking into account their nationality, age and sex. It has been recorded that with the increase of... more
The study of ACE gene I/D polymorphism has been carried out in elderly, senile and long-liver patients with coronary heart disease (CHD) taking into account their nationality, age and sex. It has been recorded that with the increase of age there is a decrease in the frequency of the genotype ACE*I/*I and a tendency of increase in the frequency of the genotype ACE*D/*D. A comparative analysis of genotypes АСЕ*D/*D and АСЕ*D/*I has showed sex differences in the frequency of homozygous genotype detection. Left ventricular hypertrophy can be observed significantly more often among carriers of genotype ACE*I/*I established by Sokolow-Lyon ECG signs. Association analysis of ACE gene I/D polymorphism has registered significant differences in BMI and blood lipid parameters.
