Choroidal Thickness

Our study examined the choroidal thickness profile of children with myopic anisometropic amblyopia and compared the thickness with the fellow eyes. The choroidal thickness was measured with the enhanced depth imaging with spectral-domain optical coherence tomography. Manual segmentations of the choroid were performed on a 25-raster horizontal scan. The choroidal thickness measurements of the 9 subfields defined by the Early Treatment Diabetic Retinopathy Study (ETDRS) were evaluated. The mean spherical equivalent of the amblyopic eyes was-10.80 ± 0.41 D and the fellow eyes was-4.40 ± 2.05 D. The mean best corrected visual acuity of the amblyopic eyes and the fellow eyes were 0.94 ± 0.27 and 0.14 ± 0.05 logMAR respectively. The amblyopic eyes have longer axial length (26.46 ± 0.44 mm) compared to the fellow eyes (23.59 ± 1.18 mm). The average subfoveal choroidal thickness was 124.30 ± 40.71 µm in the amblyopic eyes and 246.80 ± 58.63 µm in the fellow eyes. The horizontal and vertical distribution pattern of choroidal thickness in amblyopic eyes was different from the fellow eyes. In amblyopic eye the choroidal thickness reduced from the temporal region to the nasal region. The fellow eyes had thickest choroid at the subfoveal area, followed by the temporal region and nasal region. In conclusion, the choroid was thinner in the amblyopic eyes than that of the fellow eyes at all regions.

Background: Waardenburg syndrome is a rare autosomally-inherited developmental disorder characterized by sensorineural deafness in association with pigmentary anomalies comprising various ocular features including dystopia canthorum, iris heterochromia, eyebrow flare, and fundus alterations. It is a congenital non-progressive genetic disorder that has been found to result in hearing loss, reduced vision, reduced self esteem, problems related to appearance, and decreased intellectual functioning. Case Reports: We report two familial case series that presented with the characteristic ocular findings and the systemic features of Waardenburg syndrome. The first series comprised a 32-year-old father with his two sons aged nine and six years. Two female siblings, aged 10 and eight years, both with cochlear implants, were included in the second series. Conclusion: Waardenburg syndrome manifests differently with dissimilar genetic penetration even within the same family. Some individuals wi...

Background: Mydriatics drops have a broad range of applications in ocular examination and treatment. After administration,
many changes can occur in the different parts of the eye including the choroidal layer which is a vascular layer localized between
the outer sclera and inner retinal layers.
Purpose: To study effects of different mydriatics on choroidal thickness (CHT) by examining anterior chamber parameters
(corneal thickness, corneal volume, corneal curvature, anterior chamber depth (ACD), anterior chamber volume (ACV) and anterior
chamber angle (ACA).
Materials and methods: A total of 166 eyes of 83 students and employee aged 18-40 years old were enrolled in this crosssectional study. The participants were divided randomly into 3 groups based on application of drops (tropicamide group,
phenylephrine group and cyclopentolate group). All subjects underwent a full ophthalmic examination involving; visual acuity
and refraction, Slit- lamp biomicroscopy, Fundus examination, IOP measurement using noncontact tonometry, anterior chamber
parameters measurement using Pentacam Rotating Scheimpflug Camera and the choroidal thickness measurement by Optical
coherence tomography OCT.
Result: Decrease in the peri-temporal, inner-temporal, sub foveal, inner-nasal and peri-nasal choroidal thickness after drops
instillation in all groups were found to be significant (𝑝 = 0.000, 𝑝 = 0.000, 𝑝 = 0.000, 𝑝 = 0.000 and 𝑝 = 0.000 respectively), while
increase in the anterior chamber depth was found to be significant with all mydriatics (𝑝 = 0.00).
Conclusion: The study showed that while cyclopentolate, tropicamide, and phenylephrine cause a decrease in choroidal
thickness, they also lead to increase in anterior chamber depth.