The objective of the study was to investigate the alpha glucosidase and Dipeptidyl peptidase IV (DPP-IV) inhibitory activity of aqueous extract of Desmodium gangeticum (D. gangeticum). α-d- Glucosidase from Saccharomyces... more
The objective of the study was to investigate the alpha glucosidase
and Dipeptidyl peptidase IV (DPP-IV) inhibitory activity of aqueous
extract of Desmodium gangeticum (D. gangeticum). α-d- Glucosidase
from Saccharomyces cerevisiae was used as in vitro model to assess
α-d-Glucosidase inhibitory activity of aqueous extract of D.
gangeticum. In-vitro inhibitory effect of aqueous extract of D.
gangeticum on DPP-IV enzyme was assessed by measuring the
absorbance of reaction mixture at 405 nm using a microtiter plate
reader. Results of the study demonstrated that aqueous extract of D.
gangeticum exhibited good alpha glucosidase and DPP-IV inhibitory
activity with an IC
50
value of 950μg/ml and 255.5μg/ml respectively.
The results of the study provide scientific support for the use of D.
gangeticum in the traditional system of medicine for the treatment of
Type-II diabetes. This study should help to explain the
pharmacological mechanism of action and also help in the
development of medicinal preparation for the treatment of Type-II
diabetes.
Objective: Background reliable information about the prevalence of dyslipidemia in hypertensive and non hypertensive diabetic patients in local region is essential to the development of regional health policies for prevention and... more
Objective: Background reliable information about the prevalence of
dyslipidemia in hypertensive and non hypertensive diabetic patients
in local region is essential to the development of regional health
policies for prevention and control of this condition. An attempt was
made in Puducherry region to examine the lipid profile parameters in
the diabetic patients with and without hypertension and thereby to
create awareness on the importance of closely watching their lipid
parameters frequently from the age of 30-70. Method: Totally case
sheets of 105 Puducherry patients are referred covering hypertensive
and non hypertensive diabetic patients. To ascertain the significance
of each parameters student’s t-test has been done. Results: It is found
that el evated serum triglycerides (TG), very low density lipoprotein
(VLDL) and Cholesterol/High density lipoprotein Ratio
(CHOL/HDL) but normal cholesterol, low density lipoprotein (LDL)
and HDL in diabetic patients of all age groups. In both gender Serum
triglycerides are significantly elevated in diabetics of all age groups
compared to non diabetics. Plasma VLDL is significantly elevated in
female diabetic patients between the age group of 30-40 years and
60-70 years compare to non diabetics and other age groups. Plasma
VLDL is significantly elevated in male diabetic patients also between
the age group of 30-50 years compare to non diabetics and other age
groups. Conclusion: Serum TG and VLDL was found to be more
significantly increased in diabetic patients with hypertension
compared to without hypertension. Similarly serum TG is also
elevated in non diabetic hypertensive patients.
