Fibronectin
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Recent papers in Fibronectin
In immature dendritic cells (DCs) podosomes form and turn over behind the leading edge of migrating cells. The Arp2/3 complex activator Wiskott-Aldrich Syndrome Protein (WASP) localises to the actin core of forming podosomes together with... more
Surfaces in biology are present everywhere, and how biomacromolecules and cells interact with them to form interfaces is crucial in cell biology, biotechnology and medicine. For example, biosensors are based on the specific recognition of... more
Stable fixation of implants such as artificial teeth depends on the direct apposition of bone to the implanted material. While endosseous implants were traditionally allowed to "osseointegrate" over several months without... more
Curriculum Vitae
Corneal scarring is a major cause of blindness worldwide and can result from the deposition of abnormal amounts of collagen fibers lacking the correct size and spacing required to produce a clear cornea. Collagen fiber formation requires... more
Cell-sheet-engineering based regenerative medicine is successfully applied to clinical studies, though cell sheets contain uniformly distributed cells. For the further application to complex tissues/organs, cell sheets with a... more
The loss of fibronectin from tumor cell surfaces has been correlated with an increased incidence of metastases. To determine directly whether cell surface fibronectin influences the metastatic potential of solid tumors, we chemically... more
Photoageing of human skin due to chronic exposure to ultraviolet radiation (UVR) is characterized histologically by extensive remodelling of the dermal elastic fibre system. Whilst enzymatic pathways are thought to play a major role in... more
In working towards the goal of mimicking multiple features of the extracellular matrix (ECM), we developed a strategy to create adhesive protein patterns on polymer films with tunable viscous characteristics. The block copolymer films are... more