Although hepatoblastoma is the most common malign tumor in childhood in the liver there are few studies including fluorodeoxyglucose positron emission tomography/computed tomography imaging and hepatoblastoma. The patient included in this... more
Although hepatoblastoma is the most common malign tumor in childhood in the liver there are few studies including fluorodeoxyglucose positron emission tomography/computed tomography imaging and hepatoblastoma. The patient included in this report has multiple hepatic lesions with high alphaphetoprotein (AFP) levels suggestive of hepatoblastoma but no increased FDG uptake in the liver lesions who responded the chemotherapy very well.
Objective: 18 F-fluorodeoxyglucose positron emission tomography/computed tomography (18 F-FDG PET/CT) not only gives information about anatomical features of lung lesions but also about their metabolic activity. This study aimed to... more
Objective: 18 F-fluorodeoxyglucose positron emission tomography/computed tomography (18 F-FDG PET/CT) not only gives information about anatomical features of lung lesions but also about their metabolic activity. This study aimed to determine the mediastinal and parenchymal pathologies of the lung with false-positive FDG involvement and characteristics that could benefit differential diagnosis. Materials and Methods: This study retrospectively analyzed 1,924 subjects that underwent 18 F-FDG PET/CT from December 2010 to January 2015. Subjects with a maximum standardized uptake value (SUV max) value of ≥2.5 in the lung tissue, mediastinal lymph nodes with no primary lung malignancy, and a benign pathology result were included. Results: The mean age of the 143 subjects was 61.7±11.0 years. The pathologies anthracosis, granulomatous inflammatory events, and organized pneumonia (OP) were 64 (45%), 36 (25%), and 18 (13%) cases, respectively, in order of frequency. The median SUV max value of all lesions was 5.2 (min-max, 2.5-37.6). Moreover, mediastinal lymph node involvement was frequent (59%). The median SUV max value of anthracotic lesions was significantly lower than the median SUV max value of granulomatous and OP lesions (p<0.001 and p=0.007, respectively). No significant difference in the median SUV max value was noted between granulomatous and OP lesions. Conclusion: Anthracosis and tuberculosis should be considered as benign causes of mediastinal lymph node positivity in developing countries. 18 F-FDG PET/BT is an unreliable method for the differential diagnosis of benign diseases characterized by inflammation. Thus, metabolic activity evaluation is more suitable.
