NLR

Chronic obstructive pulmonary disease (COPD) is a disabling condition that is characterized by poorly reversible airflow limitation and inflammation. Acute exacerbations of COPD (AECOPD) are a common cause of hospitalization and death among COPD patients. Several biochemical markers have been studied as outcome predictors in COPD, however their measurement often requires significant time and resources. Relatively simple biomarkers of inflammation calculated from routine complete blood count tests, such as the neutrophil to lymphocyte ratio (NLR), might also predict COPD progression and outcomes. This review discusses the available evidence from studies investigating the associations between the NLR, COPD exacerbations and death in this patient group.

Background We conducted a meta‐analysis to review the available evidence regarding the associations between peripheral blood neutrophil‐to‐lymphocyte ratio (NLR) and platelet‐to‐lymphocyte ratio (PLR) and the presence of rheumatoid arthritis (RA). Methods PubMed, Web of Science, and Scopus, from inception to January 2018, were searched for studies reporting on NLR and PLR in RA in comparison to healthy subjects. Standardized mean difference (SMD) was calculated with a confidence interval (CI) of 95%. Results Thirteen NLR studies (1,550 RA patients and 1,128 healthy controls) and 8 PLR studies (380 RA patients and 305 healthy controls) were included in the meta‐analysis. NLR and PLR were significantly higher in patients with RA when compared to controls (SMD=0.79, 95% CI 0.55–1.03; p<0.001 and SMD=0.66, 95% CI 0.43–0.88; p<0.001, respectively). Conclusions The NLR and PLR are significantly associated with the presence of RA. Further studies are required to ascertain the potential clinical use of these simple and relatively inexpensive markers in RA diagnosis.

Background: Recently, a growing number of publications have suggested that the immune-inflammatory system may be involved in the etiology of bipolar disorder (BD). Objective: The aim of this study was to investigate neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR), and red cell distribution width (RDW) in the three different phases of BD patients compared to each other and controls. Methods: One hundred eighty-seven bipolar patients (78 euthymic, 53 manic/hypomanic and 56 depressed), and 62 age and sex matched controls were enrolled. Sociodemographic variables and complete blood count parameters of the patients and the control group were recorded. Results: The groups did not differ from each other on the hematological parameters, except for NLR and RDW. Post-hoc analyses revealed that NLR values were significantly higher in the euthymic and manic/hypomanic bipolar groups compared to control group. In addition, post-hoc analyses revealed that RDW values were significantly higher in the manic/hypomanic bipolar group relative to the control group. Discussion: Longitudinal studies evaluating the levels of inflammatory markers in the early phases of the disorder, and their relationship with the development of different episodes and medical comorbidities may be useful to understand the role of inflam mation in BD.

The diagnosis of psoriasis, an immune-mediated disease that affects 2% of the population in Western countries, is largely based on history and clinical examination. The aim of this systematic review and meta-analysis was to investigate the associations between the neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) and the presence and clinical severity of psoriasis. A systematic literature search was conducted in PubMed, Web of Science, and Scopus, from inception to January 2018. Twelve case-control studies enrolling 1067 psoriasis patients (537 males and 530 females) and 799 healthy controls (404 males and 395 females) were included in the meta-analysis. The NLR was evaluated in all the studies, while the PLR was assessed in four studies. Pooled results showed that both the NLR and the PLR values were significantly higher in patients with psoriasis (SMD = 0.69, 95% CI 0.53-1.85, p < 0.001, and SMD = 0.40, 95% CI 0.12-0.68, p = 0.006, respectively). There were no significant differences in NLR values according to the severity of disease (p = 0.52). The NLR and the PLR are significantly associated with the presence, but not with the severity, of psoriasis. Further studies are required to determine the additional utility of these haematological indexes in the diagnosis of psoriasis.

Amaç: Kronik inflamatuvar demiyelinizan polinöropati (KIDP) periferik sinir ve sinir köklerini etkileyen otoimmün bir hastalıkdır. Nötrofil/lenfosit oranı (NLO) basitçe hesaplanabilen ve kronik inflamasyonla seyreden hastalıklarda son yıllarda sıklıkla değerlendirilen bir parametre olmuştur. Bu çalışmada diğer bir inflamatuvar yanıt göstergesi olarak beyin omurilik sıvısı (BOS) total protein düzeyi ve NLO ortalamalarının, sinir ileti çalışmalarının sonuçları arasındaki ilişkinin araştırılması amaçlanmıştır.
Metod: Kliniğimizde yatırılarak takip edilen ve tüm bilgilerine ulaşılabilen KIDP olguları çalışmaya dahil edilmiştir. Hastaların herhangi bir tedavi başlanmadan önceki ilk başvuruları sırasında yapılan lomber ponksiyon, sinir ileti çalışmaları
ve hemogram değerleri çalışmaya temel teşkil etmiştir.
Sonuçlar: Toplam 37 (18 kadın/19 erkek) olgunun yaş ortalaması; 55±1 yıl olarak bulundu. Olguların etiyolojik dağılımı, %33’ünde Tip II diyabetes mellitus, % 19’unda monoklonal gammopati, %16’sında paraneoplazi, %5’inde konnektif
doku hastalığı iken, 7%’sinde etiyolojik neden saptanmadı. BOS protein düzeyinin ortalama değeri: 60±31mg/dl olup, olguların %38’ inde değerler, laboratuvar üst değerimiz olan 45 mg/dl’nin üzerinde bulunmuştur. Olguların yaş ortalaması ile BOS protein değeri ortalaması arasında negatif, NLR ortalaması ile pozitif korelasyon saptanmıştır.
İncelenen tüm motor sinirlerin distal latansı ile BOS protein düzeyi arasında ve median duysal latans ile NLR düzeyi
arasında pozitif korelasyon saptanmıştır.