TNF-a inhibitors
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Recent papers in TNF-a inhibitors
SPD-304 was discovered as a promising tumor necrosis factor alpha (TNF) antagonist that promotes dissociation of TNF trimers and therefore blocks the interaction of TNF and its receptor. However, SPD-304 contains a potentially toxic... more
Metadichol ® is a nano formulation of long-chain lipid alcohols derived from food It is a inverse agonist of Vitamin D receptor (VDR), Aryl hydrocarbon receptor (AHR), and ROR gamma (RORC) that could have beneficial effects on skin... more
Physicochemical and structural properties of proteins used as active pharmaceutical ingredients of bio-pharmaceuticals are determinant to carry out their biological activity. In this regard, the assays intended to evaluate functionality... more
Metadichol ® is a Nano emulsion of long-chain alcohols called as Policosanol and is present in foods such as rice, sugar cane, wheat, and peanuts. Metadichol ® acts on Nuclear Vitamin D receptors (VDR) that are present in cells throughout... more
This article analyses the biochemical object of TNF inhibitors from the perspective of living with an autoimmune disease. The author tries to tease out how the concept of immune inhibition is used in tandem with the biochemical object of... more
women than men. People not diagnosed make up the majority of thyroid patients. There is a need to find novel and safe ways to change the underlying disease processes, rather than merely stop excess thyroid hormone production as in... more
The blockade of tumor necrosis factor (TNF) by etanercept, a soluble version of the human TNF receptor 2 (hTNFR2), is a well established strategy to inhibit adverse TNF-mediated inflammatory responses in the clinic. A similar strategy is... more
reased risk of psoriatic arthritis, lymphomas, cardiovascular disease, and Crohn’s disease. Psoriasis treatments today include steroid and vitamin D3 cream, ultraviolet light, and immune systemsuppressing medications such as methotrexate.... more
Обзор посвящен современным фармакологическим подходам к лечению псориатического артрита (ПсА). Приведены данные о распространенности псориаза и псориатического поражения суставов, нередко являющегося причиной ранней инвалидизации больных.... more
Poxviruses encode up to four different soluble TNF receptors, named cytokine response modifier B (CrmB), CrmC, CrmD and CrmE. These proteins mimic the extracellular domain of the cellular TNF receptors to bind and inhibit the activity of... more
Liver diseases are becoming a major health concern. In the developing countries it is due to microbial infection. In the rest of the developed world it is due to alcohol abuse. Chronic liver disease and cirrhosis are a significant health... more
Insulin and IGF signaling require a family of scaffold proteins, also called as Insulin Receptor Substrate (IRS) proteins to integrate extracellular signals into intracellular responses, leading to cellular effects. Two main IRS proteins... more