Targeted

Nanogels are nanosized hydrogel particles formed by physical or chemical cross-linked polymer networks. The advantageous
properties of nanogels related to the ability of retaining considerable amount of water, the biocompatibility of the polymers used, the ability to encapsulate and protect a large quantity of payload drugs within the nanogel matrix, the high stability in aqueous media, their stimuli responsively behavior potential, and the versatility in release drugs in a controlled manner make them very attractive for use in the area of drug delivery. The materials used for the preparation of nanogels ranged from natural polymers like ovalbumin, pullulan,
hyaluronic acid, methacrylated chondroitin sulfate and chitosan, to synthetic polymers like poly (N isopropylacrylamide), poly (Nisopropylacrylamide-
co-acrylic acid) and poly (ethylene glycol)-b-poly (methacrylic acid). The porous nanogels have been finding application
as anti-cancer drug and imaging agent reservoirs. Smart nanogels responding to external stimuli such as temperature, pH etc can be designed for diverse therapeutic and diagnostic applications. The nanogels have also been surface functionalized with specific ligands aiding in targeted drug delivery. This review focus on stimuli-sensitive, multi-responsive, magnetic and targeted nanogels providing a
brief insight on the application of nanogels in cancer drug delivery and imaging in detail.

Successful resection of hepatocellular cancer not amenable to Milan criteria and durable complete remission induced by systemic polichemotherapy to local unavailability of novel biologic agents. After 3 months of chemotherapy biochemical remission was