Jan 15, 2024 · The imputation of unmeasured genotypes is essential in human genetic research, particularly in enhancing the power of genome-wide association studies and ...

Jan 26, 2024 · Our new method, causal-TWAS (cTWAS), borrows ideas from statistical fine-mapping and allows us to adjust all genetic confounders. cTWAS showed calibrated false ...

Jan 3, 2024 · We recently examined the impact of imputation in a chromosomal region under positive selection [2]. Variants within the region of the well-known lactase gene ( ...

May 28, 2024 · Our objective is to improve the quality of imputation in GlaxoSmithKline studies with African American subjects. Most current genetic reference panels are ...

Jul 15, 2023 · Genotype imputation is a commonly used technique that infers un-typed variants into a study's genotype data, allowing better identification of causal variants ...

Apr 20, 2024 · We conclude that genotyping, NGS, genotype imputation and downstream analyses such as GWAS and fine mapping are systematically biased in inaccessible regions, ...

Jan 22, 2024 · Improving Imputation Accuracy by Inferring Causal Variants in Genetic Studies. ... Identifying causal variants by fine mapping across multiple studies.

Mar 12, 2024 · Imputation is a general approach used in statistics that allows you to infer the identity of an unobserved data point based on previously observed patterns.

Missing: Inferring | Show results with:Inferring

Dec 21, 2023 · Improving accuracy of rare variant imputation with a two-step imputation approach. ... imputation and meta-analysis in genetic association studies. BMC ...