Drug Metabolism and Pharmacokinetics

This book, Drug Metabolism and Pharmacokinetics, delivers the latest information on biotransformation and other pharmacokinetic parameters required to assess drug safety in drug discovery and development. Drug metabolism and pharmacokinetics (DMPK) is considered a rational strategy for the design, optimization, and selection of successful drug candidates in the pre-clinical stages of drug d...

This book, Drug Metabolism and Pharmacokinetics, delivers the latest information on biotransformation and other pharmacokinetic parameters required to assess drug safety in drug discovery and development. Drug metabolism and pharmacokinetics (DMPK) is considered a rational strategy for the design, optimization, and selection of successful drug candidates in the pre-clinical stages of drug discovery. The evaluation of various pharmacokinetic parameters such as aqueous solubility, lipophilicity, cell permeability, bioavailability, protein binding, and metabolism and elimination half-life, drug–drug interactions (DDIs), and toxicokinetics is essential for a candidate drug to become a successful therapeutic agent. This book discusses recent advances in in-silico tools and in vitro/in vivo experimental techniques applied in pharmacokinetic, metabolomic, and bioanalytical studies.
Key Features:
• Presents pharmacokinetic and biotransformation parameters used for pre-clinical safety evaluations
• Depicts experimental and biophysical techniques used in bioanalytical and metabolomic studies
• Summarizes in silico, in vitro, and in vivo methods used in drug–enzyme interactions, drug– drug interactions, and toxicokinetics
Written by a global team of experts, this book is a valuable resource for drug discovery scientists, drug developers, medicinal chemists, pharmacologists, biochemists, clinicians, biomedical scientists, healthcare professionals, researchers, teaching faculty, and students.

Order Print Copy Recommend to Your Library

Your name

Your email address

Your Library’s email address

Department

Institution/Company

Loading...

Country

Loading...

Message of recommendation Dear Librarian, I would like to recommend the following IntechOpen book to be added to our library catalog: TITLE: 'Drug Metabolism and Pharmacokinetics' PRINT ISBN: 978-0-85014-147-4 Libraries are offered a 20% discount on retail book prices. For a quote, please contact the IntechOpen Print Sales Department directly at orders@intechopen.com Best regards.

I recommend this publication for the following reasons

Loading...

By submitting the form you agree to IntechOpen using your personal information in order to fulfil your library recommendation. In line with our privacy policy we won’t share your details with any third parties and will discard any personal information provided immediately after the recommended institution details are received. For further information on how we protect and process your personal information, please refer to our privacy policy.

Submit