JCI’s Conversations with Giants in Medicine: Ending one conversation

In this final episode of the series, the Conversations with Giants in Medicine series comes to a close. The JCI is heading in a new direction with its video content, and Ushma Neill too will be heading in a different career direction that makes it hard to continue the series with the same care. As is often noted, “All good things must come to an end.” Please watch a supercut of the last question she asked each subject, “What other vocation could have kept you as motivated?”

Baricitinib rapidly treats lichen planus by suppressing cytotoxic CXCL13+CD8+ T cells.

In this episode, Aaron R. Mangold explains how lichen planus is treated by suppressing cytotoxic CXCL13+CD8+ T-cells using baricitinib.

Electronic health record data and the estimation of autoimmune disease prevalence in the USA

In this video, DeLisa Fairweather, Aaron H. Abend, and Ingrid He explain that their paper estimates the prevalence of all autoimmune disease in the US, sex- and age-adjusted, with individual estimates for 105 autoimmune diseases.

JCI’s Conversations with Giants in Medicine: Zhijian (James) Chen

In this episode, Editor at Large Ushma Neill interviews Dr. Zhijian (James) Chen. Zhijian (James) Chen (University of Texas Southwestern and HHMI) has had a storied research career focused on the molecular mechanisms of innate immunity, the body's immediate response to pathogens. His discovery of the cGAS enzyme that senses foreign and self-DNA brought him to New York to accept the 2024 Albert Lasker Basic Medical Research Award for a recent conversation.

Chronic lymphocytic leukemia and the inducement of a nongenetic adaptation to ibrutinib

In this episode, Laura Ondrisova describes how this manuscript examines a non-genetic adaptation to BTK inhibitor therapy in chronic lymphocytic leukemia that involves Akt activation via FoxO1/Rictor axis.