Entry
Name
succinylornithine transaminase;
succinylornithine aminotransferase;
N2-succinylornithine 5-aminotransferase;
AstC;
SOAT;
2-N-succinyl-L-ornithine:2-oxoglutarate 5-aminotransferase
Class
Transferases;
Transferring nitrogenous groups;
Transaminases
BRITE hierarchy
Sysname
N2-succinyl-L-ornithine:2-oxoglutarate 5-aminotransferase
Reaction(IUBMB)
N2-succinyl-L-ornithine + 2-oxoglutarate = N-succinyl-L-glutamate 5-semialdehyde + L-glutamate [RN:
R04217 ]
Reaction(KEGG)
Substrate
N2-succinyl-L-ornithine [CPD:
C03415 ];
2-oxoglutarate [CPD:
C00026 ]
Product
N-succinyl-L-glutamate 5-semialdehyde [CPD:
C05932 ];
L-glutamate [CPD:
C00025 ]
Comment
A pyridoxal-phosphate protein. Also acts on N2-acetyl-L-ornithine and L-ornithine, but more slowly [3]. In Pseudomonas aeruginosa, the arginine-inducible succinylornithine transaminase, acetylornithine transaminase (EC
2.6.1.11 ) and ornithine aminotransferase (EC
2.6.1.13 ) activities are catalysed by the same enzyme, but this is not the case in all species [5]. This is the third enzyme in the arginine succinyltransferase (AST) pathway for the catabolism of arginine [1]. This pathway converts the carbon skeleton of arginine into glutamate, with the concomitant production of ammonia and conversion of succinyl-CoA into succinate and CoA. The five enzymes involved in this pathway are EC
2.3.1.109 (arginine N-succinyltransferase), EC
3.5.3.23 (N-succinylarginine dihydrolase), EC
2.6.1.81 (succinylornithine transaminase), EC
1.2.1.71 (succinylglutamate-semialdehyde dehydrogenase) and EC
3.5.1.96 (succinylglutamate desuccinylase) [3,6].
History
EC 2.6.1.81 created 2006
Pathway
ec00330 Arginine and proline metabolism
Orthology
K00840 succinylornithine aminotransferase
Genes
ECOO : ECRM13514_2245(argD)
ECOH : ECRM13516_2150(argD)
ECW : EcE24377A_1970(astC)
EDJ : ECDH1ME8569_1692(astC)
ECOI : ECOPMV1_01846(astC)
KPN : KPN_01221(argD) KPN_01493
KPU : KP1_2251(argD) KP1_2498
KPM : KPHS_21180 KPHS_23950
KPH : KPNIH24_16245(argD) KPNIH24_18025
KPZ : KPNIH27_10310 KPNIH27_11675(argD)
KPV : KPNIH29_10815 KPNIH29_11900(argD)
KPW : KPNIH30_11060 KPNIH30_12440(argD)
KPY : KPNIH31_10440 KPNIH31_11525(argD)
KPG : KPNIH32_10900 KPNIH32_12280(argD)
KPC : KPNIH10_10505 KPNIH10_11985(argD)
KPQ : KPR0928_10675 KPR0928_11995(argD)
KPT : VK055_1016 VK055_1237
KPO : KPN2242_09225 KPN2242_10250
KPR : KPR_2267 KPR_2850(astC)
KPI : D364_06330 D364_07320
KPA : KPNJ1_03002 KPNJ1_03289
KPS : KPNJ2_03002 KPNJ2_03280
KPX : PMK1_03600(astC_1) PMK1_03811(astC_2)
KPB : FH42_01970 FH42_03365(argD)
KPNE : KU54_014220(argD) KU54_015600
KPNU : LI86_14155(argD) LI86_15910
KPNK : BN49_2356(astC) BN49_2555(astC2)
KPE : KPK_2968 KPK_3222(astC)
KPK : A593_20835 A593_22015(argD)
KVD : KR75_18680 KR75_19835
KVQ : SP68_00870 SP68_25125
KQU : AVR78_15490 AVR78_16555
KQV : B8P98_15135 B8P98_16235
KAR : LGL98_13835 LGL98_14890
KPAS : LUW96_18510 LUW96_28460
REE : electrica_03010(astC)
ROR : RORB6_07430 RORB6_08560
RON : TE10_12230 TE10_13105(argD)
RPLN : B1209_14560 B1209_15905 B1209_27410
RAO : DSD31_14055 DSD31_15140
RTG : NCTC13098_04215(astC_3)
CLAP : NCTC11466_02672(astC)
KIE : NCTC12125_01666(astC)
AHN : NCTC12129_02266(astC)
METY : MRY16398_22330(astC)
EBU : CUC76_03550 CUC76_04590
YPG : YpAngola_A2520(argM)
YPI : YpsIP31758_2121(argM)
SMW : SMWW4_v1c28620(astC)
SFJ : SAMEA4384070_2887(astC)
SOF : NCTC11214_03933(astC)
KPIE : N5580_10015 N5580_21285
PAEB : NCGM1900_1827(argD)
PPSE : BN5_1490(argD1) BN5_1906(argD3)
PVD : CFBP1590__3557(argD1)
PPRC : PFLCHA0_c45870(argD2)
PMUD : NCTC8068_03954(aruC)
PFW : PF1751_v1c42620(argD)
PFF : PFLUOLIPICF714840(argD)
PPUU : PputUW4_04175(argD2)
PTW : TUM18999_42590(aruC)
PTAE : NCTC10697_03322(aruC)
PSKU : KUIN1_35300(argD_2)
MSHE : MAALD49_32750(argD)
ABC : ACICU_01135 ACICU_03334
ABB : ABBFA_00378(astC_1) ABBFA_02423(astC_2)
ABR : ABTJ_00358 ABTJ_02590
ABAD : ABD1_05420(astC) ABD1_11040(astC) ABD1_30200(astC)
ABAB : BJAB0715_01272 BJAB0715_03489
ABAJ : BJAB0868_01259 BJAB0868_03379
ABAZ : P795_11910 P795_1740
ABK : LX00_05545(argD) LX00_16830(argD)
ABAU : IX87_05430(argD) IX87_12425(argD)
ABAA : IX88_00435(argD) IX88_07710(argD)
ABAL : ABLAC_03690 ABLAC_19290
ACC : BDGL_000368(astC) BDGL_002597(astC)
ANO : RR32_01915(argD) RR32_12680(argD)
ALC : OTEC02_01815 OTEC02_13470
ACAL : BUM88_05295 BUM88_17665
ASEI : I8T81_01965 I8T81_13460
ACD : AOLE_01800 AOLE_13890
ACW : A0J50_01720(argD) A0J50_12005(argD)
ASOL : BEN76_09770 BEN76_16555
ATN : FM020_08220 FM020_15415(astC)
ATZ : M5E07_08280 M5E07_15645
ACIE : KIP84_01905 KIP84_13000
CCAH : DWG20_01565 DWG20_13830
CHAE : CH06BL_13290(argD1)
IOD : EJO50_02040 EJO50_08120
IFL : C1H71_14245 C1H71_16965
BMV : BMASAVP1_A2425(astC)
BML : BMA10229_A2866(astC)
BPM : BURPS1710b_2847(astC)
BPL : BURPS1106A_2785(astC)
BUE : BRPE67_ACDS09970(argD)
PLG : NCTC10937_03872(argD)
BUO : BRPE64_ACDS10840(argD)
JAB : VN23_01700 VN23_07890
» show all
Taxonomy
Reference
Authors
Vander Wauven C, Stalon V.
Title
Occurrence of succinyl derivatives in the catabolism of arginine in Pseudomonas cepacia.
Journal
Reference
Authors
Schneider BL, Kiupakis AK, Reitzer LJ
Title
Arginine catabolism and the arginine succinyltransferase pathway in Escherichia coli.
Journal
Sequence
Reference
Authors
Cunin R, Glansdorff N, Pierard A, Stalon V.
Title
Biosynthesis and metabolism of arginine in bacteria.
Journal
Microbiol Rev 50:314-52 (1986)
Reference
Authors
Itoh Y
Title
Cloning and characterization of the aru genes encoding enzymes of the catabolic arginine succinyltransferase pathway in Pseudomonas aeruginosa.
Journal
Sequence
Reference
Authors
Stalon V, Vander Wauven C, Momin P, Legrain C.
Title
Catabolism of arginine, citrulline and ornithine by Pseudomonas and related bacteria.
Journal
Other DBs
ExplorEnz - The Enzyme Database: 2.6.1.81
ExPASy - ENZYME nomenclature database: 2.6.1.81
LinkDB
All DBs