 | | DRUG: Onfasprodil | |
| Entry |
|
|---|
| Name |
Onfasprodil (USAN/INN) |
|---|
| Formula |
C20H23FN2O3
|
|---|
| Exact mass |
358.1693
|
|---|
| Mol weight |
358.41
|
|---|
| Structure |
|
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| Class |
Neuropsychiatric agent
DG01498 NMDA receptor antagonist
|
|---|
| Efficacy |
Antidepressant, NMDA 2B receptor antagonist |
|---|
| Comment |
Treatment of depression
|
|---|
| Target |
|
|---|
| Pathway |
| hsa04080 | Neuroactive ligand-receptor interaction |
|
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| Interaction |
|
|---|
| Brite |
Drug groups [BR:br08330]
Neuropsychiatric agent
DG01498 NMDA receptor antagonist
D12787 Onfasprodil
Target-based classification of drugs [BR:br08310]
Ion channels
Ligand-gated ion channels
Glutamate (ionotropic), NMDA
GRIN2B (NMDAR2B)
D12787 Onfasprodil (USAN/INN)
|
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| Other DBs |
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| LinkDB |
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| KCF data |
ATOM 26
1 N5x N 11.8300 -18.2000
2 C8y C 11.8300 -16.8000
3 C8x C 10.6400 -16.1000
4 C8x C 9.3800 -16.8000
5 C8y C 9.3800 -18.2000
6 C8x C 10.6400 -18.9000
7 O1a O 8.1900 -18.9000
8 C1c C 13.0200 -16.1000
9 C1b C 14.2100 -16.8000
10 O1a O 13.0200 -14.7000
11 N1y N 15.4000 -16.1000
12 C1x C 16.6600 -16.6600
13 C1y C 17.5700 -15.6100
14 C1y C 16.9400 -14.4200
15 C1x C 15.5400 -14.7700
16 C1x C 18.9700 -15.3300
17 C1y C 19.1100 -14.0000
18 C1x C 17.8500 -13.4400
19 C8y C 21.4900 -14.0000
20 O2a O 20.3000 -13.3000
21 C8y C 21.4900 -15.4000
22 C8x C 22.6800 -16.1000
23 C8x C 23.8700 -15.4000
24 C8x C 23.8700 -14.0000
25 C8x C 22.6800 -13.3000
26 X F 20.3000 -16.1000
BOND 29
1 1 2 2
2 2 3 1
3 3 4 2
4 4 5 1
5 5 6 2
6 1 6 1
7 5 7 1
8 2 8 1
9 8 9 1
10 8 10 1 #Up
11 9 11 1
12 11 12 1
13 12 13 1
14 13 14 1
15 14 15 1
16 11 15 1
17 13 16 1
18 16 17 1
19 17 18 1
20 14 18 1
21 19 20 1
22 17 20 1 #Up
23 19 21 2
24 21 22 1
25 22 23 2
26 23 24 1
27 24 25 2
28 19 25 1
29 21 26 1
|
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