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Homo sapiens (human): 2904
Help
Entry
2904 CDS
T01001
Symbol
GRIN2B, DEE27, EIEE27, GluN2B, MRD6, NMDAR2B, NR2B, NR3, hNR3
Name
(RefSeq) glutamate ionotropic receptor NMDA type subunit 2B
KO
K05210
glutamate receptor ionotropic, NMDA 2B
Organism
hsa
Homo sapiens (human)
Pathway
hsa04014
Ras signaling pathway
hsa04015
Rap1 signaling pathway
hsa04020
Calcium signaling pathway
hsa04024
cAMP signaling pathway
hsa04080
Neuroactive ligand-receptor interaction
hsa04713
Circadian entrainment
hsa04720
Long-term potentiation
hsa04724
Glutamatergic synapse
hsa04728
Dopaminergic synapse
hsa05010
Alzheimer disease
hsa05014
Amyotrophic lateral sclerosis
hsa05016
Huntington disease
hsa05017
Spinocerebellar ataxia
hsa05020
Prion disease
hsa05022
Pathways of neurodegeneration - multiple diseases
hsa05030
Cocaine addiction
hsa05031
Amphetamine addiction
hsa05033
Nicotine addiction
hsa05034
Alcoholism
hsa05322
Systemic lupus erythematosus
Network
nt06460
Alzheimer disease
nt06461
Huntington disease
nt06462
Spinocerebellar ataxia
nt06465
Prion disease
nt06466
Pathways of neurodegeneration
Element
N00970
Transport of calcium
N00971
Mutation-caused aberrant PDYN to transport of calcium
N00987
Mutation-caused aberrant Htt to transport of calcium
N01003
Mutation-caused aberrant Abeta to transport of calcium
N01200
Scrapie conformation PrPSc to transport of calcium
Disease
H00606
Early infantile epileptic encephalopathy
H00773
Autosomal dominant intellectual developmental disorder
Drug target
Acamprosate (
DG00996
):
D02780
<JP/US>
D07058
Amantadine (
DG00860
):
D00777
<JP/US>
D07441
Apimostinel:
D11299
Aptiganel hydrochloride:
D02973
Besonprodil:
D03100
Budipine (
DG00866
):
D07306
D07589
Dalzanemdor:
D12788
Delucemine hydrochloride:
D03679
Dextromethorphan (
DG01078
):
D00848
<JP>
D03742
D03744
Dextrorphan hydrochloride:
D03746
Dizocilpine maleate:
D03878
Esketamine (
DG01829
):
D07283
D10627
<US>
Esmethadone
Dextromethadone (
DG03176
):
D12214
D12215
Felbamate:
D00536
<US>
Gavestinel:
D04308
Ketamine (
DG00796
):
D00711
<JP/US>
D08098
Latrepirdine (
DG01379
):
D09917
D09918
Levomethadone (
DG01002
):
D08121
D08122
Licostinel:
D04728
Memantine (
DG00986
):
D04905
<JP/US>
D08174
Methadone (
DG00999
):
D02102
<JP/US>
D08195
Neramexane mesylate:
D05145
Nevadistinel:
D12553
Onfasprodil:
D12787
Orphenadrine (
DG01252
):
D08305
Orphenadrine (chloride):
D02599
Orphenadrine (citrate):
D00774
<US>
Perzinfotel:
D05447
Phencyclidine hydrochloride:
D05453
Remacemide hydrochloride:
D05714
Riluzole:
D00775
<JP/US>
Risevistinel:
D12554
Rislenemdaz:
D11340
Selfotel:
D02410
Tenocyclidine:
D12702
Tiletamine (
DG01380
):
D06146
D08596
Traxoprodil mesylate:
D06204
Troriluzole (
DG03011
):
D11414
D11415
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09130 Environmental Information Processing
09132 Signal transduction
04014 Ras signaling pathway
2904 (GRIN2B)
04015 Rap1 signaling pathway
2904 (GRIN2B)
04024 cAMP signaling pathway
2904 (GRIN2B)
09133 Signaling molecules and interaction
04080 Neuroactive ligand-receptor interaction
2904 (GRIN2B)
09150 Organismal Systems
09156 Nervous system
04724 Glutamatergic synapse
2904 (GRIN2B)
04728 Dopaminergic synapse
2904 (GRIN2B)
04720 Long-term potentiation
2904 (GRIN2B)
09159 Environmental adaptation
04713 Circadian entrainment
2904 (GRIN2B)
09160 Human Diseases
09163 Immune disease
05322 Systemic lupus erythematosus
2904 (GRIN2B)
09164 Neurodegenerative disease
05010 Alzheimer disease
2904 (GRIN2B)
05014 Amyotrophic lateral sclerosis
2904 (GRIN2B)
05016 Huntington disease
2904 (GRIN2B)
05017 Spinocerebellar ataxia
2904 (GRIN2B)
05020 Prion disease
2904 (GRIN2B)
05022 Pathways of neurodegeneration - multiple diseases
2904 (GRIN2B)
09165 Substance dependence
05030 Cocaine addiction
2904 (GRIN2B)
05031 Amphetamine addiction
2904 (GRIN2B)
05033 Nicotine addiction
2904 (GRIN2B)
05034 Alcoholism
2904 (GRIN2B)
09180 Brite Hierarchies
09183 Protein families: signaling and cellular processes
04040 Ion channels [BR:
hsa04040
]
2904 (GRIN2B)
Ion channels [BR:
hsa04040
]
Ligand-gated channels
Glutamate (ionotropic)
2904 (GRIN2B)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
NMDAR2_C
Lig_chan
Lig_chan-Glu_bd
ANF_receptor
SBP_bac_3
Motif
Other DBs
NCBI-GeneID:
2904
NCBI-ProteinID:
NP_000825
OMIM:
138252
HGNC:
4586
Ensembl:
ENSG00000273079
Pharos:
Q13224
(Tclin)
UniProt:
Q13224
A0A8D9PHB2
Structure
PDB
PDBj
LinkDB
All DBs
Position
12:complement(13537337..13982134)
Genome browser
AA seq
1484 aa
AA seq
DB search
MKPRAECCSPKFWLVLAVLAVSGSRARSQKSPPSIGIAVILVGTSDEVAIKDAHEKDDFH
HLSVVPRVELVAMNETDPKSIITRICDLMSDRKIQGVVFADDTDQEAIAQILDFISAQTL
TPILGIHGGSSMIMADKDESSMFFQFGPSIEQQASVMLNIMEEYDWYIFSIVTTYFPGYQ
DFVNKIRSTIENSFVGWELEEVLLLDMSLDDGDSKIQNQLKKLQSPIILLYCTKEEATYI
FEVANSVGLTGYGYTWIVPSLVAGDTDTVPAEFPTGLISVSYDEWDYGLPARVRDGIAII
TTAASDMLSEHSFIPEPKSSCYNTHEKRIYQSNMLNRYLINVTFEGRNLSFSEDGYQMHP
KLVIILLNKERKWERVGKWKDKSLQMKYYVWPRMCPETEEQEDDHLSIVTLEEAPFVIVE
SVDPLSGTCMRNTVPCQKRIVTENKTDEEPGYIKKCCKGFCIDILKKISKSVKFTYDLYL
VTNGKHGKKINGTWNGMIGEVVMKRAYMAVGSLTINEERSEVVDFSVPFIETGISVMVSR
SNGTVSPSAFLEPFSADVWVMMFVMLLIVSAVAVFVFEYFSPVGYNRCLADGREPGGPSF
TIGKAIWLLWGLVFNNSVPVQNPKGTTSKIMVSVWAFFAVIFLASYTANLAAFMIQEEYV
DQVSGLSDKKFQRPNDFSPPFRFGTVPNGSTERNIRNNYAEMHAYMGKFNQRGVDDALLS
LKTGKLDAFIYDAAVLNYMAGRDEGCKLVTIGSGKVFASTGYGIAIQKDSGWKRQVDLAI
LQLFGDGEMEELEALWLTGICHNEKNEVMSSQLDIDNMAGVFYMLGAAMALSLITFICEH
LFYWQFRHCFMGVCSGKPGMVFSISRGIYSCIHGVAIEERQSVMNSPTATMNNTHSNILR
LLRTAKNMANLSGVNGSPQSALDFIRRESSVYDISEHRRSFTHSDCKSYNNPPCEENLFS
DYISEVERTFGNLQLKDSNVYQDHYHHHHRPHSIGSASSIDGLYDCDNPPFTTQSRSISK
KPLDIGLPSSKHSQLSDLYGKFSFKSDRYSGHDDLIRSDVSDISTHTVTYGNIEGNAAKR
RKQQYKDSLKKRPASAKSRREFDEIELAYRRRPPRSPDHKRYFRDKEGLRDFYLDQFRTK
ENSPHWEHVDLTDIYKERSDDFKRDSVSGGGPCTNRSHIKHGTGDKHGVVSGVPAPWEKN
LTNVEWEDRSGGNFCRSCPSKLHNYSTTVTGQNSGRQACIRCEACKKAGNLYDISEDNSL
QELDQPAAPVAVTSNASTTKYPQSPTNSKAQKKNRNKLRRQHSYDTFVDLQKEEAALAPR
SVSLKDKGRFMDGSPYAHMFEMSAGESTFANNKSSVPTAGHHHHNNPGGGYMLSKSLYPD
RVTQNPFIPTFGDDQCLLHGSKSYFFRQPTVAGASKARPDFRALVTNKPVVSALHGAVPA
RFQKDICIGNQSNPCVPNNKNPRAFNGSSNGHVYEKLSSIESDV
NT seq
4455 nt
NT seq
+upstream
nt +downstream
nt
atgaagcccagagcggagtgctgttctcccaagttctggttggtgttggccgtcctggcc
gtgtcaggcagcagagctcgttctcagaagagcccccccagcattggcattgctgtcatc
ctcgtgggcacttccgacgaggtggccatcaaggatgcccacgagaaagatgatttccac
catctctccgtggtaccccgggtggaactggtagccatgaatgagaccgacccaaagagc
atcatcacccgcatctgtgatctcatgtctgaccggaagatccagggggtggtgtttgct
gatgacacagaccaggaagccatcgcccagatcctcgatttcatttcagcacagactctc
acccccatcctgggcatccacgggggctcctctatgataatggcagataaggatgaatcc
tccatgttcttccagtttggcccatcaattgaacagcaagcttccgtaatgctcaacatc
atggaagaatatgactggtacatcttttctatcgtcaccacctatttccctggctaccag
gactttgtaaacaagatccgcagcaccattgagaatagctttgtgggctgggagctagag
gaggtcctcctactggacatgtccctggacgatggagattctaagatccagaatcagctc
aagaaacttcaaagccccatcattcttctttactgtaccaaggaagaagccacctacatc
tttgaagtggccaactcagtagggctgactggctatggctacacgtggatcgtgcccagt
ctggtggcaggggatacagacacagtgcctgcggagttccccactgggctcatctctgta
tcatatgatgaatgggactatggcctccccgccagagtgagagatggaattgccataatc
accactgctgcttctgacatgctgtctgagcacagcttcatccctgagcccaaaagcagt
tgttacaacacccacgagaagagaatctaccagtccaatatgctaaataggtatctgatc
aatgtcacttttgaggggaggaatttgtccttcagtgaagatggctaccagatgcacccg
aaactggtgataattcttctgaacaaggagaggaagtgggaaagggtggggaagtggaaa
gacaagtccctgcagatgaagtactatgtgtggccccgaatgtgtccagagactgaagag
caggaggatgaccatctgagcattgtgaccctggaggaggcaccatttgtcattgtggaa
agtgtggaccctctgagtggaacctgcatgaggaacacagtcccctgccaaaaacgcata
gtcactgagaataaaacagacgaggagccgggttacatcaaaaaatgctgcaaggggttc
tgtattgacatccttaagaaaatttctaaatctgtgaagttcacctatgacctttacctg
gttaccaatggcaagcatgggaagaaaatcaatggaacctggaatggtatgattggagag
gtggtcatgaagagggcctacatggcagtgggctcactcaccatcaatgaggaacgatcg
gaggtggtcgacttctctgtgcccttcatagagacaggcatcagtgtcatggtgtcacgc
agcaatgggactgtctcaccttctgccttcttagagccattcagcgctgacgtatgggtg
atgatgtttgtgatgctgctcatcgtctcagccgtggctgtctttgtctttgagtacttc
agccctgtgggttataacaggtgcctcgctgatggcagagagcctggtggaccctctttc
accatcggcaaagctatttggttgctctggggtctggtgtttaacaactccgtacctgtg
cagaacccaaaggggaccacctccaagatcatggtgtcagtgtgggccttctttgctgtc
atcttcctggccagctacactgccaacttagctgccttcatgatccaagaggaatatgtg
gaccaggtttctggcctgagcgacaaaaagttccagagacctaatgacttctcaccccct
ttccgctttgggaccgtgcccaacggcagcacagagagaaatattcgcaataactatgca
gaaatgcatgcctacatgggaaagttcaaccagaggggtgtagatgatgcattgctctcc
ctgaaaacagggaaactggatgccttcatctatgatgcagcagtgctgaactatatggca
ggcagagatgaaggctgcaagctggtgaccattggcagtgggaaggtctttgcttccact
ggctatggcattgccatccaaaaagattctgggtggaagcgccaggtggaccttgctatc
ctgcagctctttggagatggggagatggaagaactggaagctctctggctcactggcatt
tgtcacaatgagaagaatgaggtcatgagcagccagctggacattgacaacatggcaggg
gtcttctacatgttgggggcggccatggctctcagcctcatcaccttcatctgcgaacac
cttttctattggcagttccgacattgctttatgggtgtctgttctggcaagcctggcatg
gtcttctccatcagcagaggtatctacagctgcatccatggggtggcgatcgaggagcgc
cagtctgtaatgaactcccccaccgcaaccatgaacaacacacactccaacatcctgcgc
ctgctgcgcacggccaagaacatggctaacctgtctggtgtgaatggctcaccgcagagc
gccctggacttcatccgacgggagtcatccgtctatgacatctcagagcaccgccgcagc
ttcacgcattctgactgcaaatcctacaacaacccgccctgtgaggagaacctcttcagt
gactacatcagtgaggtagagagaacgttcgggaacctgcagctgaaggacagcaacgtg
taccaagatcactaccaccatcaccaccggccccatagtattggcagtgccagctccatc
gatgggctctacgactgtgacaacccacccttcaccacccagtccaggtccatcagcaag
aagcccctggacatcggcctcccctcctccaagcacagccagctcagtgacctgtacggc
aaattctccttcaagagcgaccgctacagtggccacgacgacttgatccgctccgatgtc
tctgacatctcaacccacaccgtcacctatgggaacatcgagggcaatgccgccaagagg
cgtaagcagcaatataaggacagcctgaagaagcggcctgcctcggccaagtcccgcagg
gagtttgacgagatcgagctggcctaccgtcgccgaccgccccgctcccctgaccacaag
cgctacttcagggacaaggaagggctacgggacttctacctggaccagttccgaacaaag
gagaactcaccccactgggagcacgtagacctgaccgacatctacaaggagcggagtgat
gactttaagcgcgactccgtcagcggaggagggccctgtaccaacaggtctcacatcaag
cacgggacgggcgacaaacacggcgtggtcagcggggtacctgcaccttgggagaagaac
ctgaccaacgtggagtgggaggaccggtccgggggcaacttctgccgcagctgtccctcc
aagctgcacaactactccacgacggtgacgggtcagaactcgggcaggcaggcgtgcatc
cggtgtgaggcttgcaagaaagcaggcaacctgtatgacatcagtgaggacaactccctg
caggaactggaccagccggctgccccagtggcggtgacgtcaaacgcctccaccactaag
taccctcagagcccgactaattccaaggcccagaagaagaaccggaacaaactgcgccgg
cagcactcctacgacaccttcgtggacctgcagaaggaagaagccgccctggccccgcgc
agcgtaagcctgaaagacaagggccgattcatggatgggagcccctacgcccacatgttt
gagatgtcagctggcgagagcacctttgccaacaacaagtcctcagtgcccactgccgga
catcaccaccacaacaaccccggcggcgggtacatgctcagcaagtcgctctaccctgac
cgggtcacgcaaaaccctttcatccccacttttggggacgaccagtgcttgctccatggc
agcaaatcctacttcttcaggcagcccacggtggcgggggcgtcgaaagccaggccggac
ttccgggcccttgtcaccaacaagccggtggtctcggcccttcatggggccgtgccagcc
cgtttccagaaggacatctgtatagggaaccagtccaacccctgtgtgcctaacaacaaa
aaccccagggctttcaatggctccagcaatgggcatgtttatgagaaactttctagtatt
gagtctgatgtctga
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integrated database retrieval system
