| | NETWORK: N00478 | |
Entry |
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Name |
EBV BARF1 to intrinsic apoptotic pathway
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Definition |
BARF1 -> BCL2 -| (BAX,BAK1) -> CYCS == APAF1 -> CASP9 -> CASP3 |
Expanded |
K22973 -> 596 -| (581,578) -> 54205 == 317 -> 842 -> 836 |
Class |
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Type |
Pathogen
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Pathway |
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Disease |
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Gene |
596 | BCL2; BCL2, apoptosis regulator |
581 | BAX; BCL2 associated X, apoptosis regulator |
578 | BAK1; BCL2 antagonist/killer 1 |
54205 | CYCS; cytochrome c, somatic |
317 | APAF1; apoptotic peptidase activating factor 1 |
|
Perturbant |
K22973 (BARF1) | BARF1; EBV secreted protein BARF1 |
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Reference |
|
Authors |
Fu Q, He C, Mao ZR |
Title |
Epstein-Barr virus interactions with the Bcl-2 protein family and apoptosis in human tumor cells. |
Journal |
|
Reference |
|
Authors |
Sheng W, Decaussin G, Sumner S, Ooka T |
Title |
N-terminal domain of BARF1 gene encoded by Epstein-Barr virus is essential for malignant transformation of rodent fibroblasts and activation of BCL-2. |
Journal |
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Reference |
|
Authors |
Sheng W, Decaussin G, Ligout A, Takada K, Ooka T |
Title |
Malignant transformation of Epstein-Barr virus-negative Akata cells by introduction of the BARF1 gene carried by Epstein-Barr virus. |
Journal |
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LinkDB |
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