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Homo sapiens (human): 842
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Entry
842 CDS
T01001
Symbol
CASP9, APAF-3, APAF3, ICE-LAP6, MCH6, PPP1R56
Name
(RefSeq) caspase 9
KO
K04399
caspase 9 [EC:
3.4.22.62
]
Organism
hsa
Homo sapiens (human)
Pathway
hsa01524
Platinum drug resistance
hsa04115
p53 signaling pathway
hsa04151
PI3K-Akt signaling pathway
hsa04210
Apoptosis
hsa04215
Apoptosis - multiple species
hsa04370
VEGF signaling pathway
hsa04919
Thyroid hormone signaling pathway
hsa05010
Alzheimer disease
hsa05012
Parkinson disease
hsa05014
Amyotrophic lateral sclerosis
hsa05016
Huntington disease
hsa05020
Prion disease
hsa05022
Pathways of neurodegeneration - multiple diseases
hsa05130
Pathogenic Escherichia coli infection
hsa05134
Legionellosis
hsa05145
Toxoplasmosis
hsa05152
Tuberculosis
hsa05160
Hepatitis C
hsa05161
Hepatitis B
hsa05162
Measles
hsa05163
Human cytomegalovirus infection
hsa05164
Influenza A
hsa05167
Kaposi sarcoma-associated herpesvirus infection
hsa05168
Herpes simplex virus 1 infection
hsa05169
Epstein-Barr virus infection
hsa05170
Human immunodeficiency virus 1 infection
hsa05200
Pathways in cancer
hsa05210
Colorectal cancer
hsa05212
Pancreatic cancer
hsa05213
Endometrial cancer
hsa05215
Prostate cancer
hsa05222
Small cell lung cancer
hsa05223
Non-small cell lung cancer
hsa05416
Viral myocarditis
hsa05417
Lipid and atherosclerosis
Network
nt06161
Human immunodeficiency virus 1 (HIV-1)
nt06162
Hepatitis B virus (HBV)
nt06163
Hepatitis C virus (HCV)
nt06164
Kaposi sarcoma-associated herpesvirus (KSHV)
nt06165
Epstein-Barr virus (EBV)
nt06166
Human papillomavirus (HPV)
nt06167
Human cytomegalovirus (HCMV)
nt06168
Herpes simplex virus 1 (HSV-1)
nt06170
Influenza A virus (IAV)
nt06231
Apoptosis (cancer)
nt06260
Colorectal cancer
nt06263
Hepatocellular carcinoma
nt06267
Small cell lung cancer
nt06460
Alzheimer disease
nt06461
Huntington disease
nt06462
Spinocerebellar ataxia
nt06463
Parkinson disease
nt06464
Amyotrophic lateral sclerosis
nt06465
Prion disease
nt06466
Pathways of neurodegeneration
nt06524
Apoptosis
nt06528
Calcium signaling
Element
N00098
Intrinsic apoptotic pathway
N00100
BCL2-overexpression to intrinsic apoptotic pathway
N00101
DCC-apoptotic pathway
N00102
Loss of DCC to DCC-apoptotic pathway
N00146
Crosstalk between extrinsic and intrinsic apoptotic pathways
N00449
HIV Tat/Nef to crosstalk between extrinsic and intrinsic apoptotic pathways
N00478
EBV BARF1 to intrinsic apoptotic pathway
N00533
HBV HBx to Crosstalk between extrinsic and intrinsic apoptotic pathways
N00939
Escherichia EspF to intrinsic apoptotic pathway
N00967
VGCC-Ca2+ -apoptotic pathway
N00984
mGluR5-Ca2+ -apoptotic pathway
N00985
Mutation-caused aberrant Htt to mGluR5-Ca2+ -apoptotic pathway
N00987
Mutation-caused aberrant Htt to transport of calcium
N01002
Mutation-caused aberrant Abeta to mGluR5-Ca2+ -apoptotic pathway
N01005
Mutation-caused aberrant Abeta to crosstalk between extrinsic and intrinsic apoptotic pathways
N01007
Mutation-caused aberrant PSEN to mGluR5-Ca2+ -apoptotic pathway
N01031
Mutation-caused aberrant SNCA to VGCC-Ca2+ -apoptotic pathway
N01047
Mutation-activated LRRK2 to intrinsic apoptotic pathway
N01048
Mutation-inactivated PINK1 to intrinsic apoptotic pathway
N01049
Mutation-inactivated PRKN to intrinsic apoptotic pathway
N01050
Mutation-inactivated PINK1 to intrinsic apoptotic pathway
N01135
Mutation-caused aberrant SOD1 to intrinsic apoptotic pathway
N01199
Scrapie conformation PrPSc to mGluR5-Ca2+ -apoptotic pathway
N01200
Scrapie conformation PrPSc to transport of calcium
Drug target
Rimiducid:
D11195
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09130 Environmental Information Processing
09132 Signal transduction
04370 VEGF signaling pathway
842 (CASP9)
04151 PI3K-Akt signaling pathway
842 (CASP9)
09140 Cellular Processes
09143 Cell growth and death
04210 Apoptosis
842 (CASP9)
04215 Apoptosis - multiple species
842 (CASP9)
04115 p53 signaling pathway
842 (CASP9)
09150 Organismal Systems
09152 Endocrine system
04919 Thyroid hormone signaling pathway
842 (CASP9)
09160 Human Diseases
09161 Cancer: overview
05200 Pathways in cancer
842 (CASP9)
09162 Cancer: specific types
05210 Colorectal cancer
842 (CASP9)
05212 Pancreatic cancer
842 (CASP9)
05215 Prostate cancer
842 (CASP9)
05213 Endometrial cancer
842 (CASP9)
05222 Small cell lung cancer
842 (CASP9)
05223 Non-small cell lung cancer
842 (CASP9)
09172 Infectious disease: viral
05170 Human immunodeficiency virus 1 infection
842 (CASP9)
05161 Hepatitis B
842 (CASP9)
05160 Hepatitis C
842 (CASP9)
05164 Influenza A
842 (CASP9)
05162 Measles
842 (CASP9)
05168 Herpes simplex virus 1 infection
842 (CASP9)
05163 Human cytomegalovirus infection
842 (CASP9)
05167 Kaposi sarcoma-associated herpesvirus infection
842 (CASP9)
05169 Epstein-Barr virus infection
842 (CASP9)
09171 Infectious disease: bacterial
05130 Pathogenic Escherichia coli infection
842 (CASP9)
05134 Legionellosis
842 (CASP9)
05152 Tuberculosis
842 (CASP9)
09174 Infectious disease: parasitic
05145 Toxoplasmosis
842 (CASP9)
09164 Neurodegenerative disease
05010 Alzheimer disease
842 (CASP9)
05012 Parkinson disease
842 (CASP9)
05014 Amyotrophic lateral sclerosis
842 (CASP9)
05016 Huntington disease
842 (CASP9)
05020 Prion disease
842 (CASP9)
05022 Pathways of neurodegeneration - multiple diseases
842 (CASP9)
09166 Cardiovascular disease
05417 Lipid and atherosclerosis
842 (CASP9)
05416 Viral myocarditis
842 (CASP9)
09176 Drug resistance: antineoplastic
01524 Platinum drug resistance
842 (CASP9)
09180 Brite Hierarchies
09181 Protein families: metabolism
01009 Protein phosphatases and associated proteins [BR:
hsa01009
]
842 (CASP9)
01002 Peptidases and inhibitors [BR:
hsa01002
]
842 (CASP9)
Enzymes [BR:
hsa01000
]
3. Hydrolases
3.4 Acting on peptide bonds (peptidases)
3.4.22 Cysteine endopeptidases
3.4.22.62 caspase-9
842 (CASP9)
Protein phosphatases and associated proteins [BR:
hsa01009
]
Protein serine/threonine phosphatases
Phosphoprotein phosphatases (PPPs)
Protein phosphatase-1
PP1-interacting proteins (PIPs)
842 (CASP9)
Peptidases and inhibitors [BR:
hsa01002
]
Cysteine peptidases
Family C14: caspase family
842 (CASP9)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
Peptidase_C14
CARD
CARD_2
AsiA
Motif
Other DBs
NCBI-GeneID:
842
NCBI-ProteinID:
NP_001220
OMIM:
602234
HGNC:
1511
Ensembl:
ENSG00000132906
UniProt:
P55211
Structure
PDB
LinkDB
All DBs
Position
1:complement(15491401..15524912)
Genome browser
AA seq
416 aa
AA seq
DB search
MDEADRRLLRRCRLRLVEELQVDQLWDALLSRELFRPHMIEDIQRAGSGSRRDQARQLII
DLETRGSQALPLFISCLEDTGQDMLASFLRTNRQAAKLSKPTLENLTPVVLRPEIRKPEV
LRPETPRPVDIGSGGFGDVGALESLRGNADLAYILSMEPCGHCLIINNVNFCRESGLRTR
TGSNIDCEKLRRRFSSLHFMVEVKGDLTAKKMVLALLELAQQDHGALDCCVVVILSHGCQ
ASHLQFPGAVYGTDGCPVSVEKIVNIFNGTSCPSLGGKPKLFFIQACGGEQKDHGFEVAS
TSPEDESPGSNPEPDATPFQEGLRTFDQLDAISSLPTPSDIFVSYSTFPGFVSWRDPKSG
SWYVETLDDIFEQWAHSEDLQSLLLRVANAVSVKGIYKQMPGCFNFLRKKLFFKTS
NT seq
1251 nt
NT seq
+upstream
nt +downstream
nt
atggacgaagcggatcggcggctcctgcggcggtgccggctgcggctggtggaagagctg
caggtggaccagctctgggacgccctgctgagccgcgagctgttcaggccccatatgatc
gaggacatccagcgggcaggctctggatctcggcgggatcaggccaggcagctgatcata
gatctggagactcgagggagtcaggctcttcctttgttcatctcctgcttagaggacaca
ggccaggacatgctggcttcgtttctgcgaactaacaggcaagcagcaaagttgtcgaag
ccaaccctagaaaaccttaccccagtggtgctcagaccagagattcgcaaaccagaggtt
ctcagaccggaaacacccagaccagtggacattggttctggaggatttggtgatgtcggt
gctcttgagagtttgaggggaaatgcagatttggcttacatcctgagcatggagccctgt
ggccactgcctcattatcaacaatgtgaacttctgccgtgagtccgggctccgcacccgc
actggctccaacatcgactgtgagaagttgcggcgtcgcttctcctcgctgcatttcatg
gtggaggtgaagggcgacctgactgccaagaaaatggtgctggctttgctggagctggcg
cagcaggaccacggtgctctggactgctgcgtggtggtcattctctctcacggctgtcag
gccagccacctgcagttcccaggggctgtctacggcacagatggatgccctgtgtcggtc
gagaagattgtgaacatcttcaatgggaccagctgccccagcctgggagggaagcccaag
ctctttttcatccaggcctgtggtggggagcagaaagaccatgggtttgaggtggcctcc
acttcccctgaagacgagtcccctggcagtaaccccgagccagatgccaccccgttccag
gaaggtttgaggaccttcgaccagctggacgccatatctagtttgcccacacccagtgac
atctttgtgtcctactctactttcccaggttttgtttcctggagggaccccaagagtggc
tcctggtacgttgagaccctggacgacatctttgagcagtgggctcactctgaagacctg
cagtccctcctgcttagggtcgctaatgctgtttcggtgaaagggatttataaacagatg
cctggttgctttaatttcctccggaaaaaacttttctttaaaacatcataa
DBGET
integrated database retrieval system