KEGG NETWORK: N00098

NETWORK: N00098

Entry

N00098                      Network

Name

Intrinsic apoptotic pathway

Definition

(PMAIP1,BBC3,BAD,BCL2L11) -| (BCL2,BCL2L1) -| (BAX,BAK1) -> CYCS == APAF1 -> CASP9 -> (CASP3,CASP7)

Expanded

(5366,27113,572,10018) -| (596,598) -| (581,578) -> 54205 == 317 -> 842 -> (836,840)

Class

nt06524 Apoptosis
nt06260 Colorectal cancer
nt06267 Small cell lung cancer
nt06231 Apoptosis (cancer)
nt06463 Parkinson disease
nt06464 Amyotrophic lateral sclerosis
nt06466 Pathways of neurodegeneration
nt06161 Human immunodeficiency virus 1 (HIV-1)
nt06170 Influenza A virus (IAV)
nt06168 Herpes simplex virus 1 (HSV-1)
nt06165 Epstein-Barr virus (EBV)
nt06166 Human papillomavirus (HPV)

Type

Reference

Pathway

hsa04210

Apoptosis

Gene

5366	PMAIP1; phorbol-12-myristate-13-acetate-induced protein 1

27113

BBC3; BCL2 binding component 3

572	BAD; BCL2 associated agonist of cell death

10018

BCL2L11; BCL2 like 11

596	BCL2; BCL2, apoptosis regulator

598	BCL2L1; BCL2 like 1

581	BAX; BCL2 associated X, apoptosis regulator

578	BAK1; BCL2 antagonist/killer 1

54205

CYCS; cytochrome c, somatic

317	APAF1; apoptotic peptidase activating factor 1

842	CASP9; caspase 9

836	CASP3; caspase 3

840	CASP7; caspase 7

Reference

PMID:21697901

Authors

Vucic D, Dixit VM, Wertz IE

Title

Ubiquitylation in apoptosis: a post-translational modification at the edge of life and death.

Journal

Nat Rev Mol Cell Biol 12:439-52 (2011)
DOI:10.1038/nrm3143

Reference

PMID:15719025

Authors

Strasser A

Title

The role of BH3-only proteins in the immune system.

Journal

Nat Rev Immunol 5:189-200 (2005)
DOI:10.1038/nri1568

Reference

PMID:20683470

Authors

Tait SW, Green DR

Title

Mitochondria and cell death: outer membrane permeabilization and beyond.

Journal

Nat Rev Mol Cell Biol 11:621-32 (2010)
DOI:10.1038/nrm2952

LinkDB

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