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Homo sapiens (human): 598
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Entry
598 CDS
T01001
Symbol
BCL2L1, BCL-XL/S, BCL2L, BCLX, Bcl-X, PPP1R52
Name
(RefSeq) BCL2 like 1
KO
K04570
Bcl-2-like 1 (apoptosis regulator Bcl-X)
Organism
hsa
Homo sapiens (human)
Pathway
hsa01521
EGFR tyrosine kinase inhibitor resistance
hsa01524
Platinum drug resistance
hsa04014
Ras signaling pathway
hsa04064
NF-kappa B signaling pathway
hsa04115
p53 signaling pathway
hsa04137
Mitophagy - animal
hsa04140
Autophagy - animal
hsa04151
PI3K-Akt signaling pathway
hsa04210
Apoptosis
hsa04215
Apoptosis - multiple species
hsa04621
NOD-like receptor signaling pathway
hsa04630
JAK-STAT signaling pathway
hsa05012
Parkinson disease
hsa05014
Amyotrophic lateral sclerosis
hsa05022
Pathways of neurodegeneration - multiple diseases
hsa05131
Shigellosis
hsa05145
Toxoplasmosis
hsa05162
Measles
hsa05166
Human T-cell leukemia virus 1 infection
hsa05168
Herpes simplex virus 1 infection
hsa05170
Human immunodeficiency virus 1 infection
hsa05200
Pathways in cancer
hsa05202
Transcriptional misregulation in cancer
hsa05212
Pancreatic cancer
hsa05220
Chronic myeloid leukemia
hsa05222
Small cell lung cancer
hsa05225
Hepatocellular carcinoma
hsa05417
Lipid and atherosclerosis
Network
nt06161
Human immunodeficiency virus 1 (HIV-1)
nt06165
Epstein-Barr virus (EBV)
nt06166
Human papillomavirus (HPV)
nt06168
Herpes simplex virus 1 (HSV-1)
nt06170
Influenza A virus (IAV)
nt06219
JAK-STAT signaling (cancer)
nt06231
Apoptosis (cancer)
nt06240
Transcription (cancer)
nt06260
Colorectal cancer
nt06267
Small cell lung cancer
nt06276
Chronic myeloid leukemia
nt06463
Parkinson disease
nt06464
Amyotrophic lateral sclerosis
nt06466
Pathways of neurodegeneration
nt06524
Apoptosis
Element
N00055
BCR-ABL fusion kinase to Jak-STAT signaling pathway
N00098
Intrinsic apoptotic pathway
N00123
Amplified REL to transcription
N00451
HIV Tat to intrinsic apoptotic pathway
N01051
Mutation-inactivated DJ1 to intrinsic apoptotic pathway
Drug target
Navitoclax (
DG03204
):
D09935
D09936
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09130 Environmental Information Processing
09132 Signal transduction
04014 Ras signaling pathway
598 (BCL2L1)
04630 JAK-STAT signaling pathway
598 (BCL2L1)
04064 NF-kappa B signaling pathway
598 (BCL2L1)
04151 PI3K-Akt signaling pathway
598 (BCL2L1)
09140 Cellular Processes
09141 Transport and catabolism
04140 Autophagy - animal
598 (BCL2L1)
04137 Mitophagy - animal
598 (BCL2L1)
09143 Cell growth and death
04210 Apoptosis
598 (BCL2L1)
04215 Apoptosis - multiple species
598 (BCL2L1)
04115 p53 signaling pathway
598 (BCL2L1)
09150 Organismal Systems
09151 Immune system
04621 NOD-like receptor signaling pathway
598 (BCL2L1)
09160 Human Diseases
09161 Cancer: overview
05200 Pathways in cancer
598 (BCL2L1)
05202 Transcriptional misregulation in cancer
598 (BCL2L1)
09162 Cancer: specific types
05212 Pancreatic cancer
598 (BCL2L1)
05225 Hepatocellular carcinoma
598 (BCL2L1)
05220 Chronic myeloid leukemia
598 (BCL2L1)
05222 Small cell lung cancer
598 (BCL2L1)
09172 Infectious disease: viral
05166 Human T-cell leukemia virus 1 infection
598 (BCL2L1)
05170 Human immunodeficiency virus 1 infection
598 (BCL2L1)
05162 Measles
598 (BCL2L1)
05168 Herpes simplex virus 1 infection
598 (BCL2L1)
09171 Infectious disease: bacterial
05131 Shigellosis
598 (BCL2L1)
09174 Infectious disease: parasitic
05145 Toxoplasmosis
598 (BCL2L1)
09164 Neurodegenerative disease
05012 Parkinson disease
598 (BCL2L1)
05014 Amyotrophic lateral sclerosis
598 (BCL2L1)
05022 Pathways of neurodegeneration - multiple diseases
598 (BCL2L1)
09166 Cardiovascular disease
05417 Lipid and atherosclerosis
598 (BCL2L1)
09176 Drug resistance: antineoplastic
01521 EGFR tyrosine kinase inhibitor resistance
598 (BCL2L1)
01524 Platinum drug resistance
598 (BCL2L1)
09180 Brite Hierarchies
09181 Protein families: metabolism
01009 Protein phosphatases and associated proteins [BR:
hsa01009
]
598 (BCL2L1)
09182 Protein families: genetic information processing
03036 Chromosome and associated proteins [BR:
hsa03036
]
598 (BCL2L1)
09183 Protein families: signaling and cellular processes
02000 Transporters [BR:
hsa02000
]
598 (BCL2L1)
Protein phosphatases and associated proteins [BR:
hsa01009
]
Protein serine/threonine phosphatases
Phosphoprotein phosphatases (PPPs)
Protein phosphatase-1
PP1-interacting proteins (PIPs)
598 (BCL2L1)
Chromosome and associated proteins [BR:
hsa03036
]
Eukaryotic type
Centrosome formation proteins
Other centriole associated proteins
598 (BCL2L1)
Transporters [BR:
hsa02000
]
Other transporters
Pores ion channels [TC:
1
]
598 (BCL2L1)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
Bcl-2
BH4
Bcl-2_3
Motif
Other DBs
NCBI-GeneID:
598
NCBI-ProteinID:
NP_001304848
OMIM:
600039
HGNC:
992
Ensembl:
ENSG00000171552
UniProt:
Q07817
A0A0S2Z3C5
Structure
PDB
LinkDB
All DBs
Position
20:complement(31664452..31723963)
Genome browser
AA seq
233 aa
AA seq
DB search
MSQSNRELVVDFLSYKLSQKGYSWSQFSDVEENRTEAPEGTESEMETPSAINGNPSWHLA
DSPAVNGATGHSSSLDAREVIPMAAVKQALREAGDEFELRYRRAFSDLTSQLHITPGTAY
QSFEQVVNELFRDGVNWGRIVAFFSFGGALCVESVDKEMQVLVSRIAAWMATYLNDHLEP
WIQENGGWDTFVELYGNNAAAESRKGQERFNRWFLTGMTVAGVVLLGSLFSRK
NT seq
702 nt
NT seq
+upstream
nt +downstream
nt
atgtctcagagcaaccgggagctggtggttgactttctctcctacaagctttcccagaaa
ggatacagctggagtcagtttagtgatgtggaagagaacaggactgaggccccagaaggg
actgaatcggagatggagacccccagtgccatcaatggcaacccatcctggcacctggca
gacagccccgcggtgaatggagccactggccacagcagcagtttggatgcccgggaggtg
atccccatggcagcagtaaagcaagcgctgagggaggcaggcgacgagtttgaactgcgg
taccggcgggcattcagtgacctgacatcccagctccacatcaccccagggacagcatat
cagagctttgaacaggtagtgaatgaactcttccgggatggggtaaactggggtcgcatt
gtggcctttttctccttcggcggggcactgtgcgtggaaagcgtagacaaggagatgcag
gtattggtgagtcggatcgcagcttggatggccacttacctgaatgaccacctagagcct
tggatccaggagaacggcggctgggatacttttgtggaactctatgggaacaatgcagca
gccgagagccgaaagggccaggaacgcttcaaccgctggttcctgacgggcatgactgtg
gccggcgtggttctgctgggctcactcttcagtcggaaatga
DBGET
integrated database retrieval system