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KEGG   NETWORK: N01050
Entry
N01050                      Network                                
Name
Mutation-inactivated PINK1 to intrinsic apoptotic pathway
Definition
PINK1* // PRKN // BAX -> CYCS == APAF1 -> CASP9 -> CASP3
  Expanded
65018v1 // 5071 // 581 -> 54205 == 317 -> 842 -> 836
Class
nt06463 Parkinson disease
nt06466 Pathways of neurodegeneration
Type
Variant
Pathway
hsa05012  Parkinson disease
Disease
H00057  Parkinson disease
Gene
65018  PINK1; PTEN induced kinase 1
5071  PRKN; parkin RBR E3 ubiquitin protein ligase
581  BAX; BCL2 associated X, apoptosis regulator
54205  CYCS; cytochrome c, somatic
317  APAF1; apoptotic peptidase activating factor 1
842  CASP9; caspase 9
836  CASP3; caspase 3
Variant
65018v1 (PINK1*)  PINK1 mutation
Reference
PMID:17707122
  Authors
Wang HL, Chou AH, Yeh TH, Li AH, Chen YL, Kuo YL, Tsai SR, Yu ST
  Title
PINK1 mutants associated with recessive Parkinson's disease are defective in inhibiting mitochondrial release of cytochrome c.
  Journal
Neurobiol Dis 28:216-26 (2007)
DOI:10.1016/j.nbd.2007.07.010
Reference
PMID:25761946
  Authors
Franco-Iborra S, Vila M, Perier C
  Title
The Parkinson Disease Mitochondrial Hypothesis: Where Are We at?
  Journal
Neuroscientist 22:266-77 (2016)
DOI:10.1177/1073858415574600
Reference
PMID:27546335
  Authors
Bose A, Beal MF
  Title
Mitochondrial dysfunction in Parkinson's disease.
  Journal
J Neurochem 139 Suppl 1:216-231 (2016)
DOI:10.1111/jnc.13731
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