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KEGG   NETWORK: N01047
Entry
N01047                      Network                                
Name
Mutation-activated LRRK2 to intrinsic apoptotic pathway
Definition
LRRK2* -> CYCS == APAF1 -> CASP9 -> CASP3
  Expanded
120892v1 -> 54205 == 317 -> 842 -> 836
Class
nt06463 Parkinson disease
nt06466 Pathways of neurodegeneration
Type
Variant
Pathway
hsa05012  Parkinson disease
Disease
H00057  Parkinson disease
Gene
120892  LRRK2; leucine rich repeat kinase 2
54205  CYCS; cytochrome c, somatic
317  APAF1; apoptotic peptidase activating factor 1
842  CASP9; caspase 9
836  CASP3; caspase 3
Variant
120892v1 (LRRK2*)  LRRK2 mutation
Reference
PMID:25761946
  Authors
Franco-Iborra S, Vila M, Perier C
  Title
The Parkinson Disease Mitochondrial Hypothesis: Where Are We at?
  Journal
Neuroscientist 22:266-77 (2016)
DOI:10.1177/1073858415574600
Reference
PMID:27546335
  Authors
Bose A, Beal MF
  Title
Mitochondrial dysfunction in Parkinson's disease.
  Journal
J Neurochem 139 Suppl 1:216-231 (2016)
DOI:10.1111/jnc.13731
Reference
PMID:17409193
  Authors
Iaccarino C, Crosio C, Vitale C, Sanna G, Carri MT, Barone P
  Title
Apoptotic mechanisms in mutant LRRK2-mediated cell death.
  Journal
Hum Mol Genet 16:1319-26 (2007)
DOI:10.1093/hmg/ddm080
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