KEGG NETWORK: N01715

NETWORK: N01715

Entry

N01715                      Network

Name

Autophagy-vesicle nucleation/elongation/maturation, PI3P synthesis by PI3KC3-C1

Definition

PI -- PI3KC3-C1 -> PI3P -> (WIPI,ZFYVE1)

Expanded

C01194 -- (8678+5289+30849+29982+22863) -> C04549 -> ((55062,26100,11152,56270),53349)

Class

nt06532 Autophagy

Type

Reference

Pathway

hsa04140

Autophagy - animal

Gene

8678	BECN1; beclin 1

5289	PIK3C3; phosphatidylinositol 3-kinase catalytic subunit type 3

30849

PIK3R4; phosphoinositide-3-kinase regulatory subunit 4

29982

NRBF2; nuclear receptor binding factor 2

22863

ATG14; autophagy related 14

55062

WIPI1; WD repeat domain, phosphoinositide interacting 1

26100

WIPI2; WD repeat domain, phosphoinositide interacting 2

11152

WDR45; WD repeat domain 45

56270

WDR45B; WD repeat domain 45B

53349

ZFYVE1; zinc finger FYVE-type containing 1

Metabolite

C01194

1-Phosphatidyl-D-myo-inositol

C04549

1-Phosphatidyl-1D-myo-inositol 3-phosphate

Reference

PMID:24663220

Authors

Kim KH, Lee MS

Title

Autophagy--a key player in cellular and body metabolism.

Journal

Nat Rev Endocrinol 10:322-37 (2014)
DOI:10.1038/nrendo.2014.35

Reference

PMID:24343578

Authors

Russell RC, Yuan HX, Guan KL

Title

Autophagy regulation by nutrient signaling.

Journal

Cell Res 24:42-57 (2014)
DOI:10.1038/cr.2013.166

Reference

PMID:34540850

Authors

Vincent O, Anton-Esteban L, Bueno-Arribas M, Tornero-Ecija A, Navas MA, Escalante R

Title

The WIPI Gene Family and Neurodegenerative Diseases: Insights From Yeast and Dictyostelium Models.

Journal

Front Cell Dev Biol 9:737071 (2021)
DOI:10.3389/fcell.2021.737071

LinkDB

DBGET integrated database retrieval system