KEGG T01001: 30849

Homo sapiens (human): 30849

Entry

30849             CDS       T01001

Symbol

PIK3R4, VPS15, p150

Name

(RefSeq) phosphoinositide-3-kinase regulatory subunit 4

K08333

phosphoinositide-3-kinase, regulatory subunit 4 [EC:2.7.11.1]

Organism

hsa Homo sapiens (human)

Pathway

hsa04136

Autophagy - other

hsa04140

Autophagy - animal

hsa04371

Apelin signaling pathway

hsa05010

Alzheimer disease

hsa05014

Amyotrophic lateral sclerosis

hsa05016

Huntington disease

hsa05017

Spinocerebellar ataxia

hsa05022

Pathways of neurodegeneration - multiple diseases

hsa05131

Shigellosis

Network

nt06164  Kaposi sarcoma-associated herpesvirus (KSHV)
nt06181  Salmonella
nt06461  Huntington disease
nt06462  Spinocerebellar ataxia
nt06466  Pathways of neurodegeneration
nt06532  Autophagy

Element

N00155

Autophagy-vesicle nucleation/elongation/maturation, mTORC1-PI3KC3-C1

N00962

Mutation-inactivated ATXN3 to autophagy-vesicle nucleation

N00993

Mutation-caused aberrant Htt to autophagy-vesicle nucleation

N01302

Early endosomal fusion

N01715

Autophagy-vesicle nucleation/elongation/maturation, PI3P synthesis by PI3KC3-C1

N01718

Autophagy-vesicle nucleation/elongation/maturation, PACER-RUBCN-PI3KC3-C2

N01719

Autophagy-vesicle nucleation/elongation/maturation, E3 ubiquitin-ligase Malin

Brite

KEGG Orthology (KO) [BR:hsa00001]
09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    30849 (PIK3R4)
   04136 Autophagy - other
    30849 (PIK3R4)
09160 Human Diseases
  09171 Infectious disease: bacterial
   05131 Shigellosis
    30849 (PIK3R4)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    30849 (PIK3R4)
   05014 Amyotrophic lateral sclerosis
    30849 (PIK3R4)
   05016 Huntington disease
    30849 (PIK3R4)
   05017 Spinocerebellar ataxia
    30849 (PIK3R4)
   05022 Pathways of neurodegeneration - multiple diseases
    30849 (PIK3R4)
09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:hsa01001]
    30849 (PIK3R4)
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:hsa04131]
    30849 (PIK3R4)
Enzymes [BR:hsa01000]
2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     30849 (PIK3R4)
Protein kinases [BR:hsa01001]
Serine/threonine kinases: Other
  VPS15 family
   30849 (PIK3R4)
Membrane trafficking [BR:hsa04131]
Endocytosis
  Rab GTPases and associated proteins
   Rab associated proteins
    30849 (PIK3R4)
Autophagy
  Autophagosome formation proteins
   PI3K complex
    30849 (PIK3R4)

SSDB

Motif

Pfam:

VPS15-like_hel Pkinase WD40 HEAT PK_Tyr_Ser-Thr NBCH_WD40 HEAT_EZ TCAD9 APH

Other DBs

NCBI-GeneID:

NCBI-ProteinID:

OMIM:

HGNC:

Ensembl:

Pharos:

Q99570(Tbio)

UniProt:

Q99570

Structure

LinkDB

Position

3:complement(130678934..130746829)

AA seq 1358 aa
MGNQLAGIAPSQILSVESYFSDIHDFEYDKSLGSTRFFKVARAKHREGLVVVKVFAIQDP
TLPLTSYKQELEELKIRLNSAQNCLPFQKASEKASEKAAMLFRQYVRDNLYDRISTRPFL
NNIEKRWIAFQILTAVDQAHKSGVRHGDIKTENVMVTSWNWVLLTDFASFKPTYLPEDNP
ADFNYFFDTSRRRTCYIAPERFVDGGMFATELEYMRDPSTPLVDLNSNQRTRGELKRAMD
IFSAGCVIAELFTEGVPLFDLSQLLAYRNGHFFPEQVLNKIEDHSIRELVTQMIHREPDK
RLEAEDYLKQQRGNAFPEIFYTFLQPYMAQFAKETFLSADERILVIRKDLGNIIHNLCGH
DLPEKAEGEPKENGLVILVSVITSCLQTLKYCDSKLAALELILHLAPRLSVEILLDRITP
YLLHFSNDSVPRVRAEALRTLTKVLALVKEVPRNDINIYPEYILPGIAHLAQDDATIVRL
AYAENIALLAETALRFLELVQLKNLNMENDPNNEEIDEVTHPNGNYDTELQALHEMVQQK
VVTLLSDPENIVKQTLMENGITRLCVFFGRQKANDVLLSHMITFLNDKNDWHLRGAFFDS
IVGVAAYVGWQSSSILKPLLQQGLSDAEEFVIVKALYALTCMCQLGLLQKPHVYEFASDI
APFLCHPNLWIRYGAVGFITVVARQISTADVYCKLMPYLDPYITQPIIQIERKLVLLSVL
KEPVSRSIFDYALRSKDITSLFRHLHMRQKKRNGSLPDCPPPEDPAIAQLLKKLLSQGMT
EEEEDKLLALKDFMMKSNKAKANIVDQSHLHDSSQKGVIDLAALGITGRQVDLVKTKQEP
DDKRARKHVKQDSNVNEEWKSMFGSLDPPNMPQALPKGSDQEVIQTGKPPRSESSAGICV
PLSTSSQVPEVTTVQNKKPVIPVLSSTILPSTYQIRITTCKTELQQLIQQKREQCNAERI
AKQMMENAEWESKPPPPGWRPKGLLVAHLHEHKSAVNRIRVSDEHSLFATCSNDGTVKIW
NSQKMEGKTTTTRSILTYSRIGGRVKTLTFCQGSHYLAIASDNGAVQLLGIEASKLPKSP
KIHPLQSRILDQKEDGCVVDMHHFNSGAQSVLAYATVNGSLVGWDLRSSSNAWTLKHDLK
SGLITSFAVDIHQCWLCIGTSSGTMACWDMRFQLPISSHCHPSRARIRRLSMHPLYQSWV
IAAVQGNNEVSMWDMETGDRRFTLWASSAPPLSELQPSPHSVHGIYCSPADGNPILLTAG
SDMKIRFWDLAYPERSYVVAGSTSSPSVSYYRKIIEGTEVVQEIQNKQKVGPSDDTPRRG
PESLPVGHHDIITDVATFQTTQGFIVTASRDGIVKVWK

NT seq 4077 nt +upstreamnt +downstreamnt
atgggaaatcagcttgctggcattgctccctcccagatcctttctgtagagagttatttt
tcagatattcatgactttgaatatgataaaagcctggggagtactcggttttttaaagtt
gctcgagccaagcaccgagaaggcctggtcgttgtgaaggtttttgcaattcaggatccc
acattgcctttaaccagctataaacaagagctggaggaactgaaaatcaggcttaattct
gcacagaattgtctacctttccagaaagcatcagaaaaagcatctgagaaagcagctatg
ctctttaggcagtatgtgcgagacaatctctatgatcgcatcagtacccgtccattcttg
aataacattgagaagcgctggattgctttccagatcctgacagctgtggaccaagcacac
aaatctggagttcgtcatggggacatcaagactgagaatgtgatggtcaccagttggaat
tgggttcttctaactgattttgccagttttaagcccacttatcttccagaagacaacccg
gcagatttcaattatttctttgacacatcacggaggagaacttgctatattgctcctgaa
cgttttgttgatggtgggatgtttgccactgagttagaatatatgagagatccttcaact
ccgcttgtagacttaaatagcaatcagagaacaagaggagagttgaagagagcaatggac
atcttttcagcaggttgtgtgatagctgagctttttacagaaggtgtaccattatttgat
ctctctcaacttttggcttatagaaatggacattttttccctgaacaagtgctaaataaa
attgaagatcacagtatcagagaattggtaactcagatgattcaccgtgagccagataaa
cgtttagaggcagaagattacttaaaacagcagcgtggcaatgcctttcctgaaatattt
tacacttttcttcagccctacatggcccagtttgccaaggaaacgtttctttctgcagat
gagcgtattctggttatacggaaggatttgggcaacattattcacaatctctgtggacat
gatctgccagaaaaagccgaaggagagcctaaggaaaatgggctggttatcttggtatct
gttataacatcctgcctacagacccttaaatactgtgattccaaactagctgctttggaa
ctgattcttcatttggctccaagattaagtgttgaaatccttttggatcgtattactcca
tatcttttgcatttcagcaatgactctgttcctagggtgagggctgaagccttgaggacg
ttgaccaaagttcttgctctcgtcaaagaggttcctcgtaatgatatcaatatttatccg
gaatacattctgccaggcatagcccacttagcccaagatgatgctactatcgttagacta
gcctatgctgaaaacatagctctgctggcagaaacagctctgagattcctggaattagta
cagttaaaaaatcttaatatggaaaatgaccccaataatgaagaaatagatgaggttaca
catccaaatggaaattatgacacagagctccaagccttacatgaaatggtccagcagaaa
gttgttactttgctaagtgaccctgaaaatattgtaaaacaaaccttgatggaaaatgga
ataacacggctgtgtgtattctttggacgtcagaaagccaacgatgttttgttgtcccac
atgattactttcctaaatgataagaatgattggcatctacgtggagcattttttgatagt
atagttggtgttgctgcctatgttggctggcaaagctcctcaattctcaagcctctgctg
caacaaggtcttagtgatgctgaggaatttgtcattgtgaaagctctttatgcccttact
tgtatgtgccagttaggactgctacaaaaaccccatgtttacgaatttgccagtgatatt
gcccccttcctgtgtcatcccaatttatggatacgttatggtgccgtgggatttatcaca
gtggtagctcgtcaaataagtacagctgatgtctactgtaaactgatgccttatcttgac
ccatatattacccaaccaataatacagattgaaagaaaacttgttctgctcagtgtttta
aaggaaccagtaagtcgttctatatttgattatgctttgaggtctaaagatattactagc
ttgttcagacatcttcacatgcgtcagaagaaacgaaatggttctcttcccgactgccct
ccgccagaggatcctgccatagcacagcttctgaagaagttgctctcacagggaatgaca
gaggaagaggaagacaaacttctggcactgaaagacttcatgatgaaatctaataaagca
aaggccaatatagtggaccagagccatcttcatgatagtagtcagaaaggtgtaattgac
ttggcagctttaggcataactgggagacaagttgatcttgttaaaaccaaacaagaacca
gatgacaaacgggccagaaaacatgtaaaacaagactcaaatgtaaatgaagaatggaaa
agcatgtttgggtcactggacccaccaaacatgccacaggccctacctaaagggagtgat
caggaggtgattcagactgggaaacctcctcgttccgagtcctctgctggcatttgtgtc
cctttgtcaacttcttcacaggttccagaagtgacaactgtccaaaataaaaaaccagta
ataccggttttaagtagtacaatcttaccatccacctatcagattcgaattacaacttgt
aaaactgaacttcagcaactcatccagcaaaagcgggagcagtgcaatgctgagagaata
gctaagcagatgatggaaaatgctgaatgggagagtaaaccaccaccacctggatggcgt
cctaaagggctgttagttgcccatcttcatgagcataaatctgctgtgaatcgaattaga
gtctctgatgaacactcactttttgcaacatgttcaaatgatggcacagtgaaaatctgg
aacagtcaaaagatggaggggaagaccaccactaccagatctattcttacatacagccga
attggaggacgagtcaagacgctcacattctgccaaggctcccactatttagccatagca
tctgataatggtgctgtccagcttcttggaattgaggcttctaagctgcccaagtctcct
aaaatccatcctctacaaagcagaattctagatcagaaggaggacggttgtgttgtggat
atgcatcacttcaactctggagcacagtctgttcttgcctatgccactgtgaatggctct
ctggttggctgggaccttaggtcttcaagcaatgcgtggactttaaagcatgatttaaag
tcgggcctcatcacttcctttgctgtggacatccaccaatgctggctctgcattggtaca
agcagtggtaccatggcttgttgggacatgaggttccagttgccaatttcaagtcactgt
catccttccagggctcgaatcagacgcctctcaatgcaccctctgtatcagtcctgggtg
attgcagctgttcagggcaacaacgaagtgtccatgtgggacatggagactggtgacaga
agatttactctctgggccagcagtgcaccaccactttctgaattacagccttctcctcat
agcgtccatggtatctactgtagtcctgcagatggaaatcctatcctactaacagctggc
tcagatatgaaaataaggttttgggacttggcttacccagaaaggtcctatgttgttgca
ggaagtactagttccccatctgtgtcctactacaggaaaataattgaaggcactgaagtt
gtccaggaaattcagaataagcagaaagtaggaccaagtgatgacacccctcgaaggggc
ccagagtccctgcccgtgggacatcatgacatcatcactgatgtcgccacattccagacc
acacagggcttcatcgtaactgcttctagagatgggattgtgaaggtgtggaaataa

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