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Homo sapiens (human): 10383
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Entry
10383 CDS
T01001
Symbol
TUBB4B, Beta2, LCAEOD, TUBB2, TUBB2C
Name
(RefSeq) tubulin beta 4B class IVb
KO
K07375
tubulin beta
Organism
hsa
Homo sapiens (human)
Pathway
hsa04145
Phagosome
hsa04540
Gap junction
hsa04814
Motor proteins
hsa05010
Alzheimer disease
hsa05012
Parkinson disease
hsa05014
Amyotrophic lateral sclerosis
hsa05016
Huntington disease
hsa05020
Prion disease
hsa05022
Pathways of neurodegeneration - multiple diseases
hsa05130
Pathogenic Escherichia coli infection
hsa05132
Salmonella infection
Network
nt06180
Pathogenic Escherichia coli
nt06181
Salmonella
nt06460
Alzheimer disease
nt06461
Huntington disease
nt06463
Parkinson disease
nt06464
Amyotrophic lateral sclerosis
nt06465
Prion disease
nt06466
Pathways of neurodegeneration
nt06515
Regulation of kinetochore-microtubule interactions
Element
N00976
Retrograde axonal transport
N00977
Mutation-caused aberrant Htt to retrograde axonal transport
N00978
Anterograde axonal transport
N00979
Mutation-caused aberrant Htt to anterograde axonal transport
N01018
Mutation-caused aberrant Abeta to anterograde axonal transport
N01055
Mutation-caused aberrant SNCA to anterograde axonal transport
N01158
Mutation-caused aberrant DCTN1 to retrograde axonal transport
N01285
Microtubule-RHOA signaling pathway
N01286
Escherichia EspG to Microtubule-RHOA signaling pathway
N01295
Rab7-regulated microtubule minus-end directed transport
N01297
Arl8-regulated microtubule plus-end directed transport
N01298
Salmonella SifA to microtubule plus-end directed transport
N01299
Salmonella PipB2 to microtubule plus-end directed transport
N01403
Zn to anterograde axonal transport
N01414
Iron to anterograde axonal transport
N01535
Kinetochore microtubule attachment
N01544
Microtubule nucleation
N01547
Kinetochore fiber organization
N01549
Branching microtubule nucleation
N01553
Promotion of microtubule growth
N01561
Microtubule depolymerization
N01562
Microtubule depolymerization at the minus ends
Disease
H00837
Leber congenital amaurosis
Drug target
Anvatabart opadotin:
D12583
Avanbulin:
D11681
Batabulin (
DG01412
):
D03059
D06560
Belantamab mafodotin:
D11595
Brentuximab vedotin:
D09587
<JP/US>
Cabazitaxel (
DG00695
):
D09755
D10452
<JP/US>
Cantuzumab mertansine:
D03364
Cantuzumab ravtansine:
D10454
Cevipabulin (
DG01413
):
D06576
D08889
Colchicine:
D00570
<JP/US>
Denintuzumab mafodotin:
D11232
Docetaxel (
DG00694
):
D02165
<JP/US>
D07866
<JP/US>
Enfortumab vedotin:
D11525
<JP/US>
Eribulin:
D08914
<JP/US>
Estramustine (
DG00724
):
D02398
D04066
D06397
<JP/US>
Farletuzumab ecteribulin:
D12183
Glembatumumab vedotin:
D09912
Indibulin:
D10013
Ixabepilone:
D04645
<US>
Lexibulin:
D10073
Lifastuzumab vedotin:
D11238
Lisavanbulin:
D11494
Lorvotuzumab mertansine:
D09927
Maytansine:
D04864
Mecbotamab vedotin:
D12220
Mirvetuximab soravtansine:
D10954
<US>
Mivobulin isethionate:
D05062
Oberotatug ravtansine:
D12916
Opadotin:
D12582
Ozuriftmab vedotin:
D12210
Paclitaxel:
D00491
<JP/US>
Paclitaxel poliglumex:
D05333
Sabizabulin (
DG03253
):
D12519
D12520
Soblidotin:
D01919
Soravtansine:
D11228
Taltobulin:
D06001
Tasidotin hydrochloride:
D06009
Tirbanibulin (
DG03082
):
D11691
<US>
D11692
Tisotumab vedotin:
D11814
<US>
Trastuzumab emtansine:
D09980
<JP/US>
Tusamitamab ravtansine:
D12310
Vedotin:
D09691
Verubulin (
DG01411
):
D10029
D10030
Vinblastine (
DG00689
):
D01068
<JP/US>
D08675
Vincristine (
DG00690
):
D02197
<JP/US>
D08679
Vindesine (
DG00691
):
D01769
<JP>
D06304
Vinepidine sulfate:
D06305
Vinflunine:
D09032
Vinglycinate sulfate:
D06306
Vinleurosine sulfate:
D06307
Vinorelbine (
DG00692
):
D01935
<JP/US>
D08680
Vinrosidine sulfate:
D06308
Vinzolidine sulfate:
D06309
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09140 Cellular Processes
09141 Transport and catabolism
04145 Phagosome
10383 (TUBB4B)
09144 Cellular community - eukaryotes
04540 Gap junction
10383 (TUBB4B)
09142 Cell motility
04814 Motor proteins
10383 (TUBB4B)
09160 Human Diseases
09171 Infectious disease: bacterial
05130 Pathogenic Escherichia coli infection
10383 (TUBB4B)
05132 Salmonella infection
10383 (TUBB4B)
09164 Neurodegenerative disease
05010 Alzheimer disease
10383 (TUBB4B)
05012 Parkinson disease
10383 (TUBB4B)
05014 Amyotrophic lateral sclerosis
10383 (TUBB4B)
05016 Huntington disease
10383 (TUBB4B)
05020 Prion disease
10383 (TUBB4B)
05022 Pathways of neurodegeneration - multiple diseases
10383 (TUBB4B)
09180 Brite Hierarchies
09182 Protein families: genetic information processing
03036 Chromosome and associated proteins [BR:
hsa03036
]
10383 (TUBB4B)
09183 Protein families: signaling and cellular processes
04812 Cytoskeleton proteins [BR:
hsa04812
]
10383 (TUBB4B)
04147 Exosome [BR:
hsa04147
]
10383 (TUBB4B)
Chromosome and associated proteins [BR:
hsa03036
]
Eukaryotic type
Centrosome formation proteins
Microtubules and associated factors
Other tubulins
10383 (TUBB4B)
Cytoskeleton proteins [BR:
hsa04812
]
Eukaryotic cytoskeleton proteins
Microtubules
Tubulins
10383 (TUBB4B)
Exosome [BR:
hsa04147
]
Exosomal proteins
Exosomal proteins of other body fluids (saliva and urine)
10383 (TUBB4B)
Exosomal proteins of colorectal cancer cells
10383 (TUBB4B)
Exosomal proteins of bladder cancer cells
10383 (TUBB4B)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
Tubulin
Tubulin_C
Misat_Tub_SegII
Tubulin_3
Tubulin_2
Motif
Other DBs
NCBI-GeneID:
10383
NCBI-ProteinID:
NP_006079
OMIM:
602660
HGNC:
20771
Ensembl:
ENSG00000188229
UniProt:
P68371
Structure
PDB
LinkDB
All DBs
Position
9:137241287..137243707
Genome browser
AA seq
445 aa
AA seq
DB search
MREIVHLQAGQCGNQIGAKFWEVISDEHGIDPTGTYHGDSDLQLERINVYYNEATGGKYV
PRAVLVDLEPGTMDSVRSGPFGQIFRPDNFVFGQSGAGNNWAKGHYTEGAELVDSVLDVV
RKEAESCDCLQGFQLTHSLGGGTGSGMGTLLISKIREEYPDRIMNTFSVVPSPKVSDTVV
EPYNATLSVHQLVENTDETYCIDNEALYDICFRTLKLTTPTYGDLNHLVSATMSGVTTCL
RFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTSRGSQQYRALTVPELTQQMFDAKNMM
AACDPRHGRYLTVAAVFRGRMSMKEVDEQMLNVQNKNSSYFVEWIPNNVKTAVCDIPPRG
LKMSATFIGNSTAIQELFKRISEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVS
EYQQYQDATAEEEGEFEEEAEEEVA
NT seq
1338 nt
NT seq
+upstream
nt +downstream
nt
atgagggaaatcgtgcacttgcaggccgggcagtgcggcaaccaaatcggcgccaagttt
tgggaggtgatcagcgatgagcacggcatcgaccccacgggcacctaccacggggacagc
gacctgcagctggaacgcatcaacgtgtactacaatgaggccaccggcggcaagtacgtg
ccccgcgccgtgctcgtggatctggagcccggcaccatggactccgtgcgctcggggccc
ttcgggcagatcttccggccggacaacttcgttttcggtcagagtggtgctgggaacaac
tgggccaaggggcactacacagaaggcgcggagctggtggactcggtgctggatgttgtg
agaaaggaggctgagagctgtgactgcctgcagggtttccagctgacccactccctgggt
ggggggactgggtctgggatgggtaccctcctcatcagcaagatccgggaggagtaccca
gacaggatcatgaacacgtttagtgtggtgccttcgcccaaagtgtcagacacagtggtg
gagccctacaacgccaccctctcagtccaccagctcgtagaaaacacagacgagacctac
tgcattgataacgaagctctctacgacatttgcttcagaaccctaaagctgaccacgccc
acctatggtgacctgaaccacctggtgtctgctaccatgagtggggtcaccacctgcctg
cgcttcccaggccagctcaatgctgacctgcggaagctggctgtgaacatggtcccgttt
ccccggctgcacttcttcatgcccggctttgccccactgaccagccggggcagccagcag
taccgggcgctgaccgtgcccgagctcacccagcagatgtttgatgccaagaacatgatg
gctgcctgcgacccccgccatggccgctacctgacggttgccgccgtgttcaggggccgc
atgtccatgaaggaggtggatgagcaaatgcttaatgtccaaaacaaaaacagcagctat
tttgttgagtggatccccaacaatgtgaaaacggctgtctgtgacatcccacctcggggg
ctaaaaatgtccgccaccttcattggcaacagcacggccatccaggagctgttcaagcgc
atctccgagcagttcacggccatgttccggcgcaaggccttcctgcactggtacacgggc
gagggcatggacgagatggagttcaccgaggccgagagcaacatgaatgacctggtgtcc
gagtaccagcagtaccaggatgccacagccgaggaggagggcgagttcgaggaggaggct
gaggaggaggtggcctag
DBGET
integrated database retrieval system