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KEGG   NETWORK: N00976
Entry
N00976                      Network                                
Name
Retrograde axonal transport
Definition
(DCTN+DNAH+DNAI+DNALI1+DNAL) == (TUBA+TUBB)
  Expanded
((1639+10540+11258+51164+84516+10671+(10121,10120)+55860)+(25981,146754,55567,1767,1768,56171,1769,1770,196385,8701,201625,8632)+(27019,64446)+7802+(83544,10126)) == ((7846,10376,84790,7278,113457,112714,7277,51807)+(203068,81027,7280,347733,10381,10382,10383,84617,347688))
Class
nt06463 Parkinson disease
nt06464 Amyotrophic lateral sclerosis
nt06461 Huntington disease
nt06466 Pathways of neurodegeneration
Type
Reference
Gene
1639  DCTN1; dynactin subunit 1
10540  DCTN2; dynactin subunit 2
11258  DCTN3; dynactin subunit 3
51164  DCTN4; dynactin subunit 4
84516  DCTN5; dynactin subunit 5
10671  DCTN6; dynactin subunit 6
10121  ACTR1A; actin related protein 1A
10120  ACTR1B; actin related protein 1B
55860  ACTR10; actin related protein 10
25981  DNAH1; dynein axonemal heavy chain 1
146754  DNAH2; dynein axonemal heavy chain 2
55567  DNAH3; dynein axonemal heavy chain 3
1767  DNAH5; dynein axonemal heavy chain 5
1768  DNAH6; dynein axonemal heavy chain 6
56171  DNAH7; dynein axonemal heavy chain 7
1769  DNAH8; dynein axonemal heavy chain 8
1770  DNAH9; dynein axonemal heavy chain 9
196385  DNAH10; dynein axonemal heavy chain 10
8701  DNAH11; dynein axonemal heavy chain 11
201625  DNAH12; dynein axonemal heavy chain 12
8632  DNAH17; dynein axonemal heavy chain 17
27019  DNAI1; dynein axonemal intermediate chain 1
64446  DNAI2; dynein axonemal intermediate chain 2
7802  DNALI1; dynein axonemal light intermediate chain 1
83544  DNAL1; dynein axonemal light chain 1
10126  DNAL4; dynein axonemal light chain 4
7846  TUBA1A; tubulin alpha 1a
10376  TUBA1B; tubulin alpha 1b
84790  TUBA1C; tubulin alpha 1c
7278  TUBA3C; tubulin alpha 3c
113457  TUBA3D; tubulin alpha 3d
112714  TUBA3E; tubulin alpha 3e
7277  TUBA4A; tubulin alpha 4a
51807  TUBA8; tubulin alpha 8
203068  TUBB; tubulin beta class I
81027  TUBB1; tubulin beta 1 class VI
7280  TUBB2A; tubulin beta 2A class IIa
347733  TUBB2B; tubulin beta 2B class IIb
10381  TUBB3; tubulin beta 3 class III
10382  TUBB4A; tubulin beta 4A class IVa
10383  TUBB4B; tubulin beta 4B class IVb
84617  TUBB6; tubulin beta 6 class V
347688  TUBB8; tubulin beta 8 class VIII
Reference
  Authors
Gibbs KL, Greensmith L, Schiavo G
  Title
Regulation of Axonal Transport by Protein Kinases.
  Journal
Trends Biochem Sci 40:597-610 (2015)
DOI:10.1016/j.tibs.2015.08.003
Reference
  Authors
Millecamps S, Julien JP
  Title
Axonal transport deficits and neurodegenerative diseases.
  Journal
Nat Rev Neurosci 14:161-76 (2013)
DOI:10.1038/nrn3380
Reference
  Authors
Conde C, Caceres A
  Title
Microtubule assembly, organization and dynamics in axons and dendrites.
  Journal
Nat Rev Neurosci 10:319-32 (2009)
DOI:10.1038/nrn2631
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