| Entry |
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| Symbol |
TUBA4A, ALS22, H2-ALPHA, TUBA1
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| Name |
(RefSeq) tubulin alpha 4a
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| KO |
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| Organism |
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| Pathway |
| hsa05022 | Pathways of neurodegeneration - multiple diseases |
| hsa05130 | Pathogenic Escherichia coli infection |
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| Network |
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| Element |
| N00976 | Retrograde axonal transport |
| N00977 | Mutation-caused aberrant Htt to retrograde axonal transport |
| N00978 | Anterograde axonal transport |
| N00979 | Mutation-caused aberrant Htt to anterograde axonal transport |
| N01018 | Mutation-caused aberrant Abeta to anterograde axonal transport |
| N01055 | Mutation-caused aberrant SNCA to anterograde axonal transport |
| N01158 | Mutation-caused aberrant DCTN1 to retrograde axonal transport |
| N01159 | Mutation-caused aberrant TUBA4A to retrograde axonal transport |
| N01285 | Microtubule-RHOA signaling pathway |
| N01286 | Escherichia EspG to Microtubule-RHOA signaling pathway |
| N01295 | Rab7-regulated microtubule minus-end directed transport |
| N01297 | Arl8-regulated microtubule plus-end directed transport |
| N01298 | Salmonella SifA to microtubule plus-end directed transport |
| N01299 | Salmonella PipB2 to microtubule plus-end directed transport |
| N01403 | Zn to anterograde axonal transport |
| N01414 | Iron to anterograde axonal transport |
| N01535 | Kinetochore microtubule attachment |
| N01547 | Kinetochore fiber organization |
| N01549 | Branching microtubule nucleation |
| N01553 | Promotion of microtubule growth |
| N01561 | Microtubule depolymerization |
| N01562 | Microtubule depolymerization at the minus ends |
| N01832 | NTN1-MAP1B axon guidance signaling |
| N01833 | DRAXIN-MAP1B axon guidance signaling |
| N01834 | SEMA3A-MAP1B axon guidance signaling |
| N01835 | SEMA3-CRMP2/MAPT axon guidance signaling |
| N01836 | Microtubule plus end regulation network |
| N01837 | Regulation of neurite extension, NAV1-TRIO |
| N01838 | Regulation of synaptic plasticity, p140Cap |
| N01839 | Severing of microtubule, SPAST/KATN |
| N01840 | Severing of microtubule, KIF2A |
| N01841 | Anterograde axonal transport, Kinesin-2 |
| N01842 | Anterograde axonal/dendrite transport, Kinesin-3 |
| N01843 | Anterograde dendrite transport, Kinesin-4 |
| N01844 | Anterograde dendrite transport, Kinesin-6 |
| N01845 | Anterograde axonal/dendrite transport, Kinesin-12 |
| N01846 | Retrograde axonal/dendrite transport, Dynein |
| N01857 | SEMA3A-DCX axon guidance signaling |
| N01858 | EFNB1-MAPT axon guidance signaling |
| N01859 | Anterograde axonal/dendrite transport, Kinesin-1 |
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| Disease |
| H00058 | Amyotrophic lateral sclerosis (ALS) |
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| Brite |
KEGG Orthology (KO) [BR:hsa00001]
09140 Cellular Processes
09141 Transport and catabolism
04145 Phagosome
7277 (TUBA4A)
09142 Cell motility
04814 Motor proteins
7277 (TUBA4A)
09160 Human Diseases
09171 Infectious disease: bacterial
05130 Pathogenic Escherichia coli infection
7277 (TUBA4A)
09164 Neurodegenerative disease
05010 Alzheimer disease
7277 (TUBA4A)
05012 Parkinson disease
7277 (TUBA4A)
05014 Amyotrophic lateral sclerosis
7277 (TUBA4A)
05016 Huntington disease
7277 (TUBA4A)
05020 Prion disease
7277 (TUBA4A)
05022 Pathways of neurodegeneration - multiple diseases
7277 (TUBA4A)
09180 Brite Hierarchies
09182 Protein families: genetic information processing
03019 Messenger RNA biogenesis [BR:hsa03019]
7277 (TUBA4A)
03036 Chromosome and associated proteins [BR:hsa03036]
7277 (TUBA4A)
09183 Protein families: signaling and cellular processes
04812 Cytoskeleton proteins [BR:hsa04812]
7277 (TUBA4A)
04147 Exosome [BR:hsa04147]
7277 (TUBA4A)
Messenger RNA biogenesis [BR:hsa03019]
Eukaryotic type
mRNA surveillance and transport factors
mRNA cycle factors
P-body specific factors
7277 (TUBA4A)
Chromosome and associated proteins [BR:hsa03036]
Eukaryotic type
Centrosome formation proteins
Microtubules and associated factors
Other tubulins
7277 (TUBA4A)
Cytoskeleton proteins [BR:hsa04812]
Eukaryotic cytoskeleton proteins
Microtubules
Tubulins
7277 (TUBA4A)
Exosome [BR:hsa04147]
Exosomal proteins
Exosomal proteins of haemopoietic cells (B-cell, T-cell, DC-cell, reticulocyte, and mast cell)
7277 (TUBA4A)
Exosomal proteins of other body fluids (saliva and urine)
7277 (TUBA4A)
Exosomal proteins of colorectal cancer cells
7277 (TUBA4A)
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| SSDB |
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| Motif |
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| Other DBs |
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| LinkDB |
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| Position |
2:complement(219249710..219254740)
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| AA seq |
448 aa
MRECISVHVGQAGVQMGNACWELYCLEHGIQPDGQMPSDKTIGGGDDSFTTFFCETGAGK
HVPRAVFVDLEPTVIDEIRNGPYRQLFHPEQLITGKEDAANNYARGHYTIGKEIIDPVLD
RIRKLSDQCTGLQGFLVFHSFGGGTGSGFTSLLMERLSVDYGKKSKLEFSIYPAPQVSTA
VVEPYNSILTTHTTLEHSDCAFMVDNEAIYDICRRNLDIERPTYTNLNRLISQIVSSITA
SLRFDGALNVDLTEFQTNLVPYPRIHFPLATYAPVISAEKAYHEQLSVAEITNACFEPAN
QMVKCDPRHGKYMACCLLYRGDVVPKDVNAAIAAIKTKRSIQFVDWCPTGFKVGINYQPP
TVVPGGDLAKVQRAVCMLSNTTAIAEAWARLDHKFDLMYAKRAFVHWYVGEGMEEGEFSE
AREDMAALEKDYEEVGIDSYEDEDEGEE |
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| NT seq |
1347 nt +upstreamnt +downstreamnt
atgcgtgaatgcatctcagtccacgtggggcaggcaggtgtccagatgggcaatgcctgc
tgggagctctattgcttggaacatgggattcagcctgatgggcagatgcccagtgacaag
accattggtggaggggacgactccttcaccaccttcttctgtgaaactggtgctggaaaa
cacgtaccccgggcagtttttgtggatctggagcctacggtcattgatgagatccgaaat
ggcccataccgacagctcttccacccagagcagctcatcactgggaaagaggatgctgcc
aacaactatgcccgtggtcactataccattggcaaggagatcattgacccagtgctggat
cggatccgcaagctgtctgaccagtgcacaggacttcagggcttcctggtgttccacagc
tttggtgggggcactggctctggcttcacctcactcctgatggagcggctctctgttgac
tatggcaagaaatccaagctggaattctccatctacccagccccccaggtgtctacagcc
gtggtcgagccctacaactctatcctgaccacccacaccaccctggagcactcagactgt
gccttcatggtggacaacgaagcaatctatgacatctgccgccgcaacctagacatcgag
cgcccaacctacaccaacctcaatcgcctcattagccaaattgtctcctccatcacagct
tctctgcgctttgacggggccctcaatgtggacctgacagagttccagaccaacctggtg
ccctaccctcgcatccacttccccctggccacctatgcaccagtcatctctgcagaaaag
gcataccacgagcagctgtcggtggcagagatcaccaatgcctgctttgagcctgccaac
cagatggtaaagtgtgatccccggcacggcaagtacatggcctgctgcctgctgtaccgt
ggagatgtggtgcccaaggatgtcaacgctgccattgccgccatcaagaccaagcgcagc
attcagtttgtggactggtgccccacaggcttcaaggttggtatcaactaccagcctccc
actgtggtgcctgggggtgacctggccaaggtgcagcgtgccgtgtgcatgctgagcaac
acgaccgccatcgccgaggcctgggcccgcctggaccacaagttcgacctgatgtatgcc
aagagggcgtttgtgcactggtatgtgggtgagggcatggaggagggtgagttctccgag
gcccgtgaggatatggctgccctggagaaggattatgaggaggtgggcatcgactcctat
gaggacgaggatgagggagaagaataa |
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