| Entry |
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| Symbol |
TUBB, CDCBM6, CSCSC1, M40, OK/SW-cl.56, TUBB1, TUBB5
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| Name |
(RefSeq) tubulin beta class I
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| KO |
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| Organism |
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| Pathway |
| hsa05022 | Pathways of neurodegeneration - multiple diseases |
| hsa05130 | Pathogenic Escherichia coli infection |
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| Network |
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| Element |
| N00976 | Retrograde axonal transport |
| N00977 | Mutation-caused aberrant Htt to retrograde axonal transport |
| N00978 | Anterograde axonal transport |
| N00979 | Mutation-caused aberrant Htt to anterograde axonal transport |
| N01018 | Mutation-caused aberrant Abeta to anterograde axonal transport |
| N01055 | Mutation-caused aberrant SNCA to anterograde axonal transport |
| N01158 | Mutation-caused aberrant DCTN1 to retrograde axonal transport |
| N01285 | Microtubule-RHOA signaling pathway |
| N01286 | Escherichia EspG to Microtubule-RHOA signaling pathway |
| N01295 | Rab7-regulated microtubule minus-end directed transport |
| N01297 | Arl8-regulated microtubule plus-end directed transport |
| N01298 | Salmonella SifA to microtubule plus-end directed transport |
| N01299 | Salmonella PipB2 to microtubule plus-end directed transport |
| N01403 | Zn to anterograde axonal transport |
| N01414 | Iron to anterograde axonal transport |
| N01535 | Kinetochore microtubule attachment |
| N01547 | Kinetochore fiber organization |
| N01549 | Branching microtubule nucleation |
| N01553 | Promotion of microtubule growth |
| N01561 | Microtubule depolymerization |
| N01562 | Microtubule depolymerization at the minus ends |
| N01832 | NTN1-MAP1B axon guidance signaling |
| N01833 | DRAXIN-MAP1B axon guidance signaling |
| N01834 | SEMA3A-MAP1B axon guidance signaling |
| N01835 | SEMA3-CRMP2/MAPT axon guidance signaling |
| N01836 | Microtubule plus end regulation network |
| N01837 | Regulation of neurite extension, NAV1-TRIO |
| N01838 | Regulation of synaptic plasticity, p140Cap |
| N01839 | Severing of microtubule, SPAST/KATN |
| N01840 | Severing of microtubule, KIF2A |
| N01841 | Anterograde axonal transport, Kinesin-2 |
| N01842 | Anterograde axonal/dendrite transport, Kinesin-3 |
| N01843 | Anterograde dendrite transport, Kinesin-4 |
| N01844 | Anterograde dendrite transport, Kinesin-6 |
| N01845 | Anterograde axonal/dendrite transport, Kinesin-12 |
| N01846 | Retrograde axonal/dendrite transport, Dynein |
| N01857 | SEMA3A-DCX axon guidance signaling |
| N01858 | EFNB1-MAPT axon guidance signaling |
| N01859 | Anterograde axonal/dendrite transport, Kinesin-1 |
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| Disease |
| H01579 | Congenital symmetric circumferential skin creases |
| H01881 | Complex cortical dysplasia with other brain malformations |
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| Drug target |
| Brentuximab vedotin: | D09587<JP/US> |
| Denintuzumab mafodotin: | D11232 |
| Enfortumab vedotin: | D11525<JP/US> |
| Farletuzumab ecteribulin: | D12183 |
| Lorvotuzumab mertansine: | D09927 |
| Mirvetuximab soravtansine: | D10954<US> |
| Tasidotin hydrochloride: | D06009 |
| Trastuzumab emtansine: | D09980<JP/US> |
| Tusamitamab ravtansine: | D12310 |
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| Brite |
KEGG Orthology (KO) [BR:hsa00001]
09140 Cellular Processes
09141 Transport and catabolism
04145 Phagosome
203068 (TUBB)
09142 Cell motility
04814 Motor proteins
203068 (TUBB)
09160 Human Diseases
09171 Infectious disease: bacterial
05130 Pathogenic Escherichia coli infection
203068 (TUBB)
09164 Neurodegenerative disease
05010 Alzheimer disease
203068 (TUBB)
05012 Parkinson disease
203068 (TUBB)
05014 Amyotrophic lateral sclerosis
203068 (TUBB)
05016 Huntington disease
203068 (TUBB)
05020 Prion disease
203068 (TUBB)
05022 Pathways of neurodegeneration - multiple diseases
203068 (TUBB)
09180 Brite Hierarchies
09182 Protein families: genetic information processing
03036 Chromosome and associated proteins [BR:hsa03036]
203068 (TUBB)
09183 Protein families: signaling and cellular processes
04812 Cytoskeleton proteins [BR:hsa04812]
203068 (TUBB)
04147 Exosome [BR:hsa04147]
203068 (TUBB)
Chromosome and associated proteins [BR:hsa03036]
Eukaryotic type
Centrosome formation proteins
Microtubules and associated factors
Other tubulins
203068 (TUBB)
Cytoskeleton proteins [BR:hsa04812]
Eukaryotic cytoskeleton proteins
Microtubules
Tubulins
203068 (TUBB)
Exosome [BR:hsa04147]
Exosomal proteins
Exosomal proteins of other body fluids (saliva and urine)
203068 (TUBB)
Exosomal proteins of colorectal cancer cells
203068 (TUBB)
Exosomal proteins of bladder cancer cells
203068 (TUBB)
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| SSDB |
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| Motif |
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| Other DBs |
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| Structure |
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| LinkDB |
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| Position |
6:30720352..30725422
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| AA seq |
444 aa
MREIVHIQAGQCGNQIGAKFWEVISDEHGIDPTGTYHGDSDLQLDRISVYYNEATGGKYV
PRAILVDLEPGTMDSVRSGPFGQIFRPDNFVFGQSGAGNNWAKGHYTEGAELVDSVLDVV
RKEAESCDCLQGFQLTHSLGGGTGSGMGTLLISKIREEYPDRIMNTFSVVPSPKVSDTVV
EPYNATLSVHQLVENTDETYCIDNEALYDICFRTLKLTTPTYGDLNHLVSATMSGVTTCL
RFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTSRGSQQYRALTVPELTQQVFDAKNMM
AACDPRHGRYLTVAAVFRGRMSMKEVDEQMLNVQNKNSSYFVEWIPNNVKTAVCDIPPRG
LKMAVTFIGNSTAIQELFKRISEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVS
EYQQYQDATAEEEEDFGEEAEEEA |
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| NT seq |
1335 nt +upstreamnt +downstreamnt
atgagggaaatcgtgcacatccaggctggtcagtgtggcaaccagatcggtgccaagttc
tgggaggtgatcagtgatgaacatggcatcgaccccaccggcacctaccacggggacagc
gacctgcagctggaccgcatctctgtgtactacaatgaagccacaggtggcaaatatgtt
cctcgtgccatcctggtggatctagaacctgggaccatggactctgttcgctcaggtcct
tttggccagatctttagaccagacaactttgtatttggtcagtctggggcaggtaacaac
tgggccaaaggccactacacagagggcgccgagctggttgattctgtcctggatgtggta
cggaaggaggcagagagctgtgactgcctgcagggcttccagctgacccactcactgggc
gggggcacaggctctggaatgggcactctccttatcagcaagatccgagaagaataccct
gatcgcatcatgaataccttcagtgtggtgccttcacccaaagtgtctgacaccgtggtc
gagccctacaatgccaccctctccgtccatcagttggtagagaatactgatgagacctat
tgcattgacaacgaggccctctatgatatctgcttccgcactctgaagctgaccacacca
acctacggggatctgaaccaccttgtctcagccaccatgagtggtgtcaccacctgcctc
cgtttccctggccagctcaatgctgacctccgcaagttggcagtcaacatggtccccttc
ccacgtctccatttctttatgcctggctttgcccctctcaccagccgtggaagccagcag
tatcgagctctcacagtgccggaactcacccagcaggtcttcgatgccaagaacatgatg
gctgcctgtgacccccgccacggccgatacctcaccgtggctgctgtcttccgtggtcgg
atgtccatgaaggaggtcgatgagcagatgcttaacgtgcagaacaagaacagcagctac
tttgtggaatggatccccaacaatgtcaagacagccgtctgtgacatcccacctcgtggc
ctcaagatggcagtcaccttcattggcaatagcacagccatccaggagctcttcaagcgc
atctcggagcagttcactgccatgttccgccggaaggccttcctccactggtacacaggc
gagggcatggacgagatggagttcaccgaggctgagagcaacatgaacgacctcgtctct
gagtatcagcagtaccaggatgccaccgcagaagaggaggaggatttcggtgaggaggcc
gaagaggaggcctaa |
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