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Recent Advances in MRI of Multiple Sclerosis

A special issue of Diagnostics (ISSN 2075-4418). This special issue belongs to the section "Medical Imaging and Theranostics".

Deadline for manuscript submissions: 30 November 2025 | Viewed by 1389

Special Issue Editor

Special Issue Information

Dear Colleagues,

We are excited to extend an invitation for the submission of your original or review research papers on multiple sclerosis (MS) imaging. As MS continues to pose significant challenges in diagnosis, monitoring, and treatment, the role of advanced imaging techniques in unraveling its complex pathophysiology has become increasingly pivotal. We welcome submissions encompassing a diverse range of topics, including the following: the development and validation of novel MRI methods for the early detection and characterization of MS lesions; advancements in quantitative imaging techniques and biomarkers to aid in disease monitoring, treatment response assessment, and prognostication; elucidation of the mechanisms underlying neurodegeneration and remyelination processes through longitudinal imaging studies; exploration of the role of advanced imaging in unraveling the heterogeneity of MS phenotypes and guiding personalized therapeutic strategies; and the integration of multimodal imaging approaches in order to provide comprehensive insights into the structural, functional, and molecular alterations that occur in the MS brain and spinal cord. Your contributions hold the potential to advance our understanding of MS pathophysiology and transform clinical practice, ultimately leading to improved outcomes for individuals living with this challenging neurological disorder.

Prof. Dr. Tim Duong
Guest Editor

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Keywords

  • primary progressive MS (PPMS)
  • secondary progressive MS (SPMS)
  • relapsing–remitting MS (RRMS)
  • MRI
  • demyelination
  • dys-myelination
  • neurocognitive function
  • EDSS score

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Published Papers (1 paper)

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Review

25 pages, 6842 KiB  
Review
Ultra-High Contrast (UHC) MRI of the Brain, Spinal Cord and Optic Nerves in Multiple Sclerosis Using Directly Acquired and Synthetic Bipolar Filter (BLAIR) Images
by Paul Condron, Daniel M. Cornfeld, Mark Bydder, Eryn E. Kwon, Karen Whitehead, Emanuele Pravatà, Helen Danesh-Meyer, Catherine Shi, Taylor C. Emsden, Gil Newburn, Miriam Scadeng, Samantha J. Holdsworth and Graeme M. Bydder
Diagnostics 2025, 15(3), 329; https://doi.org/10.3390/diagnostics15030329 - 30 Jan 2025
Viewed by 958
Abstract
In this educational review, the basic physics underlying the use of ultra-high contrast (UHC) bipolar filter (BLAIR) sequences, including divided subtracted inversion recovery (dSIR), is explained. These sequences can increase the contrast produced by small changes in T1 by a factor of [...] Read more.
In this educational review, the basic physics underlying the use of ultra-high contrast (UHC) bipolar filter (BLAIR) sequences, including divided subtracted inversion recovery (dSIR), is explained. These sequences can increase the contrast produced by small changes in T1 by a factor of ten or more compared with conventional IR sequences. In illustrative cases, the sequences were used in multiple sclerosis (MS) patients during relapse and remission and were compared with positionally matched conventional (T2-weighted spin echo, T2-FLAIR) images. Well-defined focal lesions were seen with dSIR sequences in areas where little or no change was seen with conventional sequences. In addition, widespread abnormalities affecting almost all of the white matter of the brain were seen during relapses when there were no corresponding abnormalities seen on conventional sequences (the whiteout sign). Grayout signs, in which there is a loss of contrast in gray matter or between gray matter and CSF, were also seen, as well as high signal boundaries around lesions. Disruption of the usual high signal boundary between white and gray matter was seen in leucocortical lesions. Lesions in the spinal cord were better seen or only seen with dSIR sequences. Generalized change was observed in the optic nerve with the dSIR sequence in a case of optic neuritis. UHC BLAIR sequences may be of considerable value for recognition of abnormalities in clinical practice and in research studies on MS. Full article
(This article belongs to the Special Issue Recent Advances in MRI of Multiple Sclerosis)
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