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Urologic Oncology: Recent Advances in Clinical Diagnosis and Treatment

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Oncology".

Deadline for manuscript submissions: 20 December 2024 | Viewed by 1016

Special Issue Editor


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Guest Editor
Unit of Radiation Oncology, Ospedale del Mare, ASL Napoli 1 Centro, 80147 Naples, Italy
Interests: urologic oncology; oncologic radiotherapy; radiodiagnosis; radiomics; precision medicine

Special Issue Information

Dear Colleagues,

Prostate cancer, as you well know, comprises 4% of malignancies, and about 1,414,259 people worldwide were diagnosed with prostate cancer in 2020. It is the fourth most commonly diagnosed cancer in the world and causes 330,000 deaths annually. A team of medical professionals, including radiation oncologists, medical oncologists, radiologists, nuclear medicine specialists and urologists, work together to help patients manage this condition. Treatment options vary based on factors such as cancer type and stage, patient preferences, and potential side effects.

Radiation therapy is a key treatment for prostate cancer. Radiotherapy can be used alone or with other treatments, such as surgery and hormonal therapy, to destroy cancer cells. Benefits of radiotherapy include the preservation of organ function and its effectiveness on all kinds of patients, allowing them to avoid the side effects caused by surgery. The use of AI in prostate radiological diagnosis and radiotherapeutic treatment has shown promising results in optimizing and standardizing patient workflow. AI algorithms can help identify patterns and predict oncological and toxicity outcomes, leading to better clinical decision-making.

Hormono-radiotherapy is the currently accepted treatment for local and locally advanced prostate cancer. Nevertheless, recent developments in radiotherapy, particularly intensity-modulated radiotherapy, molecular imaging-guided radiotherapy, adaptive radiotherapy, and proton therapy, show that image-guided MRI therapy can reduce the long-term toxicity of radiation therapy and improve efficacy. Lastly, the immune system plays a vital role in fighting these cancers, and we have a lot of data with promising results for recurrent or metastatic prostate cancers, where an addictive effect was demonstrated with radiotherapy in oligometastatic patients, particularly.

For this Special Issue, I invite you to submit research papers, reviews, cancer biomarkers, and professional opinions that discuss the topic of local, locally advanced, and metastatic prostate cancers.

Prof. Dr. Cesare Guida
Guest Editor

Manuscript Submission Information

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Keywords

  • urologic oncology
  • oncologic radiotherapy
  • radiodiagnosis
  • radiomics
  • precision medicine

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Published Papers (1 paper)

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13 pages, 3424 KiB  
Case Report
Germ Cell Tumor of the Testis: Lethal Subtypes of a Curable Cancer
by Jamaal C. Jackson, Darren Sanchez, Andrew C. Johns, Matthew T. Campbell, Ahmet M. Aydin, Neriman Gokden, Sanjay Maraboyina, Jason L. Muesse, John F. Ward, Louis L. Pisters, Niki M. Zacharias, Charles C. Guo and Shi-Ming Tu
J. Clin. Med. 2024, 13(12), 3436; https://doi.org/10.3390/jcm13123436 - 12 Jun 2024
Viewed by 767
Abstract
Germ cell tumor of the testis (GCT) is a curable cancer even when it is widely metastatic; however, outcomes can differ based on tumor histology. Chemo-resistance in certain phenotypes, such as teratoma and yolk sac tumor, contributes to poor clinical outcomes in some [...] Read more.
Germ cell tumor of the testis (GCT) is a curable cancer even when it is widely metastatic; however, outcomes can differ based on tumor histology. Chemo-resistance in certain phenotypes, such as teratoma and yolk sac tumor, contributes to poor clinical outcomes in some patients with GCT. Despite this resistance to S-YSTemic therapy, many of these tumor subtypes remain amenable to surgical resection and possible cure. In this study, we report on a series of seven patients highlighting two chemo-resistant subtypes of nonseminomatous germ cell tumor (NSGCT), sarcomatoid yolk sac tumor (S-YST), and epithelioid trophoblastic tumor (ETT) for which early resection rather than additional salvage chemotherapy or high-dose intense chemotherapy might provide a superior clinical outcome and enhance cure rate. Full article
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