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Keywords = image processing

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22 pages, 2496 KiB  
Article
Design and Analysis of a Novel Fractional-Order System with Hidden Dynamics, Hyperchaotic Behavior and Multi-Scroll Attractors
by Fei Yu, Shuai Xu, Yue Lin, Ting He, Chaoran Wu and Hairong Lin
Mathematics 2024, 12(14), 2227; https://doi.org/10.3390/math12142227 - 17 Jul 2024
Viewed by 241
Abstract
The design of chaotic systems with complex dynamic behaviors has always been a key aspect of chaos theory in engineering applications. This study introduces a novel fractional-order system characterized by hidden dynamics, hyperchaotic behavior, and multi-scroll attractors. By employing fractional calculus, the system’s [...] Read more.
The design of chaotic systems with complex dynamic behaviors has always been a key aspect of chaos theory in engineering applications. This study introduces a novel fractional-order system characterized by hidden dynamics, hyperchaotic behavior, and multi-scroll attractors. By employing fractional calculus, the system’s order is extended beyond integer values, providing a richer dynamic behavior. The system’s hidden dynamics are revealed through detailed numerical simulations and theoretical analysis, demonstrating complex attractors and bifurcations. The hyperchaotic nature of the system is verified through Lyapunov exponents and phase portraits, showing multiple positive exponents that indicate a higher degree of unpredictability and complexity. Additionally, the system’s multi-scroll attractors are analyzed, showcasing their potential for secure communication and encryption applications. The fractional-order approach enhances the system’s flexibility and adaptability, making it suitable for a wide range of practical uses, including secure data transmission, image encryption, and complex signal processing. Finally, based on the proposed fractional-order system, we designed a simple and efficient medical image encryption scheme and analyzed its security performance. Experimental results validate the theoretical findings, confirming the system’s robustness and effectiveness in generating complex chaotic behaviors. Full article
(This article belongs to the Special Issue Chaotic Systems and Their Applications, 2nd Edition)
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13 pages, 2867 KiB  
Article
Innovative Approaches to Clinical Diagnosis: Transfer Learning in Facial Image Classification for Celiac Disease Identification
by Elif Keskin Bilgiç, İnci Zaim Gökbay and Yusuf Kayar
Appl. Sci. 2024, 14(14), 6207; https://doi.org/10.3390/app14146207 - 17 Jul 2024
Viewed by 263
Abstract
Background: Celiac disease arises from gluten consumption and shares symptoms with other conditions, leading to delayed diagnoses. Untreated celiac disease heightens the risk of autoimmune disorders, neurological issues, and certain cancers like lymphoma while also impacting skin health due to intestinal disruptions. This [...] Read more.
Background: Celiac disease arises from gluten consumption and shares symptoms with other conditions, leading to delayed diagnoses. Untreated celiac disease heightens the risk of autoimmune disorders, neurological issues, and certain cancers like lymphoma while also impacting skin health due to intestinal disruptions. This study uses facial photos to distinguish individuals with celiac disease from those without. Surprisingly, there is a lack of research involving transfer learning for this purpose despite its benefits such as faster training, enhanced performance, and reduced overfitting. While numerous studies exist on endoscopic intestinal photo classification and a few have explored the link between facial morphology measurements and celiac disease, none have concentrated on diagnosing celiac disease through facial photo classification. Methods: This study sought to apply transfer learning techniques with VGG16 to address a gap in research by identifying distinct facial features that differentiate patients with celiac disease from healthy individuals. A dataset containing a total of 200 facial images of adult individuals with and without celiac condition was utilized. Half of the dataset had a ratio of 70% females to 30% males with celiac condition, and the rest had a ratio of 60% females to 40% males without celiac condition. Among those with celiac condition, 28 were newly diagnosed and 72 had been previously diagnosed, with 25 not adhering to a gluten-free diet and 47 partially adhering to such a diet. Results: Utilizing transfer learning, the model achieved a 73% accuracy in classifying the facial images of the patients during testing, with corresponding precision, recall, and F1 score values of 0.54, 0.56, and 0.52, respectively. The training process involved 50,178 parameters, showcasing the model’s efficacy in diagnostic image analysis. Conclusions: The model correctly classified approximately three-quarters of the test images. While this is a reasonable level of accuracy, it also suggests that there is room for improvement as the dataset contains images that are inherently difficult to classify even for humans. Increasing the proportion of newly diagnosed patients in the dataset and expanding the dataset size could notably improve the model’s efficacy. Despite being the first study in this field, further refinement holds promise for the development of a diagnostic tool for celiac disease using transfer learning in medical image analysis, addressing the lack of prior studies in this area. Full article
(This article belongs to the Special Issue Application of Decision Support Systems in Biomedical Engineering)
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25 pages, 22407 KiB  
Article
Analysing Land Cover Change in the Valencian Community through Landsat Imagery: From 1984 to 2022
by Jose Antonio Sobrino, Sergio Gimeno, Virginia Crisafulli and Álvaro Sobrino-Gómez
Land 2024, 13(7), 1072; https://doi.org/10.3390/land13071072 - 17 Jul 2024
Viewed by 288
Abstract
Land cover change represents one of the most significant global transformations, which has profound impacts on ecosystems, biological diversity, and the ongoing climate crisis. In this study, our objective was to analyse land cover transformation in the Valencian Community over the last four [...] Read more.
Land cover change represents one of the most significant global transformations, which has profound impacts on ecosystems, biological diversity, and the ongoing climate crisis. In this study, our objective was to analyse land cover transformation in the Valencian Community over the last four decades. Utilising Landsat 5, 8, and 9 summer images, a Random Forest algorithm renowned for its ability to handle large datasets and complex variables, was employed to produce land cover classifications consisting of five categories: ‘Urban Areas’, ‘Dense Vegetation’, ‘Sparse Vegetation’, ‘Water Bodies’, and Other’. The results were validated through in situ measurements comparing with pre-existing products and utilising a confusion matrix. Over the study period, the urban area practically doubled, increasing from approximately 482 to 940 square kilometres. This expansion was concentrated mainly in the proximity of the already existing urban zone and occurred primarily between 1985 and 1990. The Dense and Sparse Vegetation classes exhibit substantial fluctuations over the years, displaying a subtle trend towards a decrease in their cumulative value. Water bodies and Other classes do not show substantial changes over the years. The Random Forest algorithm showed a high Overall Accuracy (OA) of 95% and Kappa values of 93%, showing good agreement with field measurements (88% OA), ESA World Cover (80% OA), and the Copernicus Global Land Service Land Cover Map (73% OA), confirming the effectiveness of this methodology in generating land cover classifications. Full article
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18 pages, 2231 KiB  
Article
Reducing Manual Annotation Costs for Cell Segmentation by Upgrading Low-Quality Annotations
by Serban Vădineanu, Daniël M. Pelt, Oleh Dzyubachyk and Kees Joost Batenburg
J. Imaging 2024, 10(7), 172; https://doi.org/10.3390/jimaging10070172 - 17 Jul 2024
Viewed by 244
Abstract
Deep-learning algorithms for cell segmentation typically require large data sets with high-quality annotations to be trained with. However, the annotation cost for obtaining such sets may prove to be prohibitively expensive. Our work aims to reduce the time necessary to create high-quality annotations [...] Read more.
Deep-learning algorithms for cell segmentation typically require large data sets with high-quality annotations to be trained with. However, the annotation cost for obtaining such sets may prove to be prohibitively expensive. Our work aims to reduce the time necessary to create high-quality annotations of cell images by using a relatively small well-annotated data set for training a convolutional neural network to upgrade lower-quality annotations, produced at lower annotation costs. We investigate the performance of our solution when upgrading the annotation quality for labels affected by three types of annotation error: omission, inclusion, and bias. We observe that our method can upgrade annotations affected by high error levels from 0.3 to 0.9 Dice similarity with the ground-truth annotations. We also show that a relatively small well-annotated set enlarged with samples with upgraded annotations can be used to train better-performing cell segmentation networks compared to training only on the well-annotated set. Moreover, we present a use case where our solution can be successfully employed to increase the quality of the predictions of a segmentation network trained on just 10 annotated samples. Full article
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16 pages, 11233 KiB  
Article
Study on the Anti-Inflammatory Mechanism of Coumarins in Peucedanum decursivum Based on Spatial Metabolomics Combined with Network Pharmacology
by Zeyu Li and Qian Li
Molecules 2024, 29(14), 3346; https://doi.org/10.3390/molecules29143346 - 17 Jul 2024
Viewed by 340
Abstract
Peucedanum decursivum (Miq.) Maxim (P. decursivum) is a traditional Chinese medicinal plant with pharmacological effects such as anti-inflammatory and anti-tumor effects, the root of which is widely used as medicine. Determining the spatial distribution and pharmacological mechanisms of metabolites is necessary [...] Read more.
Peucedanum decursivum (Miq.) Maxim (P. decursivum) is a traditional Chinese medicinal plant with pharmacological effects such as anti-inflammatory and anti-tumor effects, the root of which is widely used as medicine. Determining the spatial distribution and pharmacological mechanisms of metabolites is necessary when studying the effective substances of medicinal plants. As a means of obtaining spatial distribution information of metabolites, mass spectrometry imaging has high sensitivity and allows for molecule visualization. In this study, matrix-assisted laser desorption mass spectrometry (MALDI-TOF-MSI) and network pharmacology were used for the first time to visually study the spatial distribution and anti-inflammatory mechanism of coumarins, which are metabolites of P. decursivum, to determine their tissue localization and mechanism of action. A total of 27 coumarins were identified by MALDI-TOF-MSI, which mainly concentrated in the cortex, periderm, and phloem of the root of P. decursivum. Network pharmacology studies have identified key targets for the anti-inflammatory effect of P. decursivum, such as TNF, PTGS2, and PRAKA. GO enrichment and KEGG pathway analyses indicated that coumarins in P. decursivum mainly participated in biological processes such as inflammatory response, positive regulation of protein kinase B signaling, chemical carcinogenesis receptor activation, pathways in cancer, and other biological pathways. The molecular docking results indicated that there was good binding between components and targets. This study provides a basis for understanding the spatial distribution and anti-inflammatory mechanism of coumarins in P. decursivum. Full article
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16 pages, 4099 KiB  
Article
Multi-Frequency Spectral–Spatial Interactive Enhancement Fusion Network for Pan-Sharpening
by Yunxuan Tang, Huaguang Li, Guangxu Xie, Peng Liu and Tong Li
Electronics 2024, 13(14), 2802; https://doi.org/10.3390/electronics13142802 - 16 Jul 2024
Viewed by 233
Abstract
The objective of pan-sharpening is to effectively fuse high-resolution panchromatic (PAN) images with limited spectral information and low-resolution multispectral (LR-MS) images, thereby generating a fused image with a high spatial resolution and rich spectral information. However, current fusion techniques face significant challenges, including [...] Read more.
The objective of pan-sharpening is to effectively fuse high-resolution panchromatic (PAN) images with limited spectral information and low-resolution multispectral (LR-MS) images, thereby generating a fused image with a high spatial resolution and rich spectral information. However, current fusion techniques face significant challenges, including insufficient edge detail, spectral distortion, increased noise, and limited robustness. To address these challenges, we propose a multi-frequency spectral–spatial interaction enhancement network (MFSINet) that comprises the spectral–spatial interactive fusion (SSIF) and multi-frequency feature enhancement (MFFE) subnetworks. The SSIF enhances both spatial and spectral fusion features by optimizing the characteristics of each spectral band through band-aware processing. The MFFE employs a variant of wavelet transform to perform multiresolution analyses on remote sensing scenes, enhancing the spatial resolution, spectral fidelity, and the texture and structural features of the fused images by optimizing directional and spatial properties. Moreover, qualitative analysis and quantitative comparative experiments using the IKONOS and WorldView-2 datasets indicate that this method significantly improves the fidelity and accuracy of the fused images. Full article
(This article belongs to the Topic Computational Intelligence in Remote Sensing: 2nd Edition)
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20 pages, 5692 KiB  
Article
HLFSRNN-MIL: A Hybrid Multi-Instance Learning Model for 3D CT Image Classification
by Huilong Chen and Xiaoxia Zhang
Appl. Sci. 2024, 14(14), 6186; https://doi.org/10.3390/app14146186 - 16 Jul 2024
Viewed by 284
Abstract
At present, many diseases are diagnosed by computer tomography (CT) image technology, which affects the health of the lives of millions of people. In the process of disease confrontation, it is very important for patients to detect diseases in the early stage by [...] Read more.
At present, many diseases are diagnosed by computer tomography (CT) image technology, which affects the health of the lives of millions of people. In the process of disease confrontation, it is very important for patients to detect diseases in the early stage by deep learning of 3D CT images. The paper offers a hybrid multi-instance learning model (HLFSRNN-MIL), which hybridizes high-low frequency feature fusion (HLFFF) with sequential recurrent neural network (SRNN) for CT image classification tasks. Firstly, the hybrid model uses Resnet-50 as the deep feature. The main feature of the HLFSRNN-MIL lies in its ability to make full use of the advantages of the HLFFF and SRNN methods to make up for their own weakness; i.e., the HLFFF can extract more targeted feature information to avoid the problem of excessive gradient fluctuation during training, and the SRNN is used to process the time-related sequences before classification. The experimental study of the HLFSRNN-MIL model is on two public CT datasets, namely, the Cancer Imaging Archive (TCIA) dataset on lung cancer and the China Consortium of Chest CT Image Investigation (CC-CCII) dataset on pneumonia. The experimental results show that the model exhibits better performance and accuracy. On the TCIA dataset, HLFSRNN-MIL with Residual Network (ResNet) as the feature extractor achieves an accuracy (ACC) of 0.992 and an area under curve (AUC) of 0.997. On the CC-CCII dataset, HLFSRNN-MIL achieves an ACC of 0.994 and an AUC of 0.997. Finally, compared with the existing methods, HLFSRNN-MIL has obvious advantages in all aspects. These experimental results demonstrate that HLFSRNN-MIL can effectively solve the disease problem in the field of 3D CT images. Full article
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41 pages, 33915 KiB  
Article
Four Transformer-Based Deep Learning Classifiers Embedded with an Attention U-Net-Based Lung Segmenter and Layer-Wise Relevance Propagation-Based Heatmaps for COVID-19 X-ray Scans
by Siddharth Gupta, Arun K. Dubey, Rajesh Singh, Mannudeep K. Kalra, Ajith Abraham, Vandana Kumari, John R. Laird, Mustafa Al-Maini, Neha Gupta, Inder Singh, Klaudija Viskovic, Luca Saba and Jasjit S. Suri
Diagnostics 2024, 14(14), 1534; https://doi.org/10.3390/diagnostics14141534 - 16 Jul 2024
Viewed by 390
Abstract
Background: Diagnosing lung diseases accurately is crucial for proper treatment. Convolutional neural networks (CNNs) have advanced medical image processing, but challenges remain in their accurate explainability and reliability. This study combines U-Net with attention and Vision Transformers (ViTs) to enhance lung disease [...] Read more.
Background: Diagnosing lung diseases accurately is crucial for proper treatment. Convolutional neural networks (CNNs) have advanced medical image processing, but challenges remain in their accurate explainability and reliability. This study combines U-Net with attention and Vision Transformers (ViTs) to enhance lung disease segmentation and classification. We hypothesize that Attention U-Net will enhance segmentation accuracy and that ViTs will improve classification performance. The explainability methodologies will shed light on model decision-making processes, aiding in clinical acceptance. Methodology: A comparative approach was used to evaluate deep learning models for segmenting and classifying lung illnesses using chest X-rays. The Attention U-Net model is used for segmentation, and architectures consisting of four CNNs and four ViTs were investigated for classification. Methods like Gradient-weighted Class Activation Mapping plus plus (Grad-CAM++) and Layer-wise Relevance Propagation (LRP) provide explainability by identifying crucial areas influencing model decisions. Results: The results support the conclusion that ViTs are outstanding in identifying lung disorders. Attention U-Net obtained a Dice Coefficient of 98.54% and a Jaccard Index of 97.12%. ViTs outperformed CNNs in classification tasks by 9.26%, reaching an accuracy of 98.52% with MobileViT. An 8.3% increase in accuracy was seen while moving from raw data classification to segmented image classification. Techniques like Grad-CAM++ and LRP provided insights into the decision-making processes of the models. Conclusions: This study highlights the benefits of integrating Attention U-Net and ViTs for analyzing lung diseases, demonstrating their importance in clinical settings. Emphasizing explainability clarifies deep learning processes, enhancing confidence in AI solutions and perhaps enhancing clinical acceptance for improved healthcare results. Full article
(This article belongs to the Special Issue Artificial Intelligence in Biomedical Image Analysis—2nd Edition)
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16 pages, 1341 KiB  
Article
DSCEH: Dual-Stream Correlation-Enhanced Deep Hashing for Image Retrieval
by Yulin Yang, Huizhen Chen, Rongkai Liu, Shuning Liu, Yu Zhan, Chao Hu and Ronghua Shi
Mathematics 2024, 12(14), 2221; https://doi.org/10.3390/math12142221 - 16 Jul 2024
Viewed by 234
Abstract
Deep Hashing is widely used for large-scale image-retrieval tasks to speed up the retrieval process. Current deep hashing methods are mainly based on the Convolutional Neural Network (CNN) or Vision Transformer (VIT). They only use the local or global features for low-dimensional mapping [...] Read more.
Deep Hashing is widely used for large-scale image-retrieval tasks to speed up the retrieval process. Current deep hashing methods are mainly based on the Convolutional Neural Network (CNN) or Vision Transformer (VIT). They only use the local or global features for low-dimensional mapping and only use the similarity loss function to optimize the correlation between pairwise or triplet images. Therefore, the effectiveness of deep hashing methods is limited. In this paper, we propose a dual-stream correlation-enhanced deep hashing framework (DSCEH), which uses the local and global features of the image for low-dimensional mapping and optimizes the correlation of images from the model architecture. DSCEH consists of two main steps: model training and deep-hash-based retrieval. During the training phase, a dual-network structure comprising CNN and VIT is employed for feature extraction. Subsequently, feature fusion is achieved through a concatenation operation, followed by similarity evaluation based on the class token acquired from VIT to establish edge relationships. The Graph Convolutional Network is then utilized to enhance correlation optimization between images, resulting in the generation of high-quality hash codes. This stage facilitates the development of an optimized hash model for image retrieval. In the retrieval stage, all images within the database and the to-be-retrieved images are initially mapped to hash codes using the aforementioned hash model. The retrieval results are subsequently determined based on the Hamming distance between the hash codes. We conduct experiments on three datasets: CIFAR-10, MSCOCO, and NUSWIDE. Experimental results show the superior performance of DSCEH, which helps with fast and accurate image retrieval. Full article
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17 pages, 3887 KiB  
Article
Investigation of Metal Powder Blending for PBF-LB/M Using Particle Tracing with Ti-6Al-4V
by Ina Ludwig, Anatol Gerassimenko and Philipp Imgrund
J. Manuf. Mater. Process. 2024, 8(4), 151; https://doi.org/10.3390/jmmp8040151 - 16 Jul 2024
Viewed by 383
Abstract
Laser-based powder bed fusion of metals (PBF-LB/M) is the most used additive manufacturing (AM) technology for metal parts. Nevertheless, challenges persist in effectively managing metal powder, particularly in blending methodologies in the choice of blenders as well as in the verification of blend [...] Read more.
Laser-based powder bed fusion of metals (PBF-LB/M) is the most used additive manufacturing (AM) technology for metal parts. Nevertheless, challenges persist in effectively managing metal powder, particularly in blending methodologies in the choice of blenders as well as in the verification of blend results. In this study, a bespoke laboratory-scale AM blender is developed, tailored to address these challenges, prioritizing low-impact blending to mitigate powder degradation. As a blending type, a V-shape tumbling geometry meeting the requirements for laboratory AM usage is chosen based on a literature assessment. The implementation of thermal oxidation as a powder marking technique enables particle tracing. Blending validation is achieved using light microscopy for area measurement based on binary image processing. The powder size and shape remain unaffected after marking and blending. Only a small narrowing of the particle size distribution is detected after 180 min of blending. The V-shape tumbling blender efficiently yields a completely random state in under 10 min for rotational speeds of 20, 40, and 60 rounds per minute. In conclusion, this research underscores the critical role of blender selection in AM and advocates for continued exploration to refine powder blending practices, with the aim of advancing the capabilities and competitiveness of AM technologies. Full article
(This article belongs to the Special Issue Industry 4.0: Manufacturing and Materials Processing)
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19 pages, 9328 KiB  
Article
Covert Communication for Dual Images with Two-Tier Bits Flipping
by Shuying Xu, Jui-Chuan Liu, Ching-Chun Chang and Chin-Chen Chang
Mathematics 2024, 12(14), 2219; https://doi.org/10.3390/math12142219 - 16 Jul 2024
Viewed by 237
Abstract
Data hiding in digital images is a potent solution for covert communication, embedding sensitive data into cover images. However, most existing methods are tailored for one-to-one scenarios, which present security risks. To mitigate this vulnerability, we introduce an innovative one-to-two data hiding scheme [...] Read more.
Data hiding in digital images is a potent solution for covert communication, embedding sensitive data into cover images. However, most existing methods are tailored for one-to-one scenarios, which present security risks. To mitigate this vulnerability, we introduce an innovative one-to-two data hiding scheme that employs a two-tier bit-flipping strategy to embed sensitive data in dual images. This process produces two stego images which are then transmitted to two distinct recipients who cannot extract any sensitive data alone. The sensitive data can only be extracted when the two recipients trust each other. Through this method, we can secure the stego images. The experimental results illustrate that our method achieves an excellent data payload while maintaining high visual quality. Full article
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11 pages, 3199 KiB  
Communication
Accurate Determination of Camera Quantum Efficiency from a Single Image
by Yuri Rzhanov
J. Imaging 2024, 10(7), 169; https://doi.org/10.3390/jimaging10070169 - 16 Jul 2024
Viewed by 308
Abstract
Knowledge of spectral sensitivity is important for high-precision comparison of images taken by different cameras and recognition of objects and interpretation of scenes for which color is an important cue. Direct estimation of quantum efficiency curves (QECs) is a complicated and tedious process [...] Read more.
Knowledge of spectral sensitivity is important for high-precision comparison of images taken by different cameras and recognition of objects and interpretation of scenes for which color is an important cue. Direct estimation of quantum efficiency curves (QECs) is a complicated and tedious process requiring specialized equipment, and many camera manufacturers do not make spectral characteristics publicly available. This has led to the development of indirect techniques that are unreliable due to being highly sensitive to noise in the input data, and which often require the imposition of additional ad hoc conditions, some of which do not always hold. We demonstrate the reason for the lack of stability in the determination of QECs and propose an approach that guarantees the stability of QEC reconstruction, even in the presence of noise. A device for the realization of this approach is also proposed. The reported results were used as a basis for the granted US patent. Full article
(This article belongs to the Special Issue Color in Image Processing and Computer Vision)
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18 pages, 9010 KiB  
Article
Real-Time Precision in 3D Concrete Printing: Controlling Layer Morphology via Machine Vision and Learning Algorithms
by João M. Silva, Gabriel Wagner, Rafael Silva, António Morais, João Ribeiro, Sacha Mould, Bruno Figueiredo, João M. Nóbrega and Paulo J. S. Cruz
Inventions 2024, 9(4), 80; https://doi.org/10.3390/inventions9040080 - 16 Jul 2024
Viewed by 362
Abstract
3D concrete printing (3DCP) requires precise adjustments to parameters to ensure accurate and high-quality prints. However, despite technological advancements, manual intervention still plays a prominent role in this process, leading to errors and inconsistencies in the final printed part. To address this issue, [...] Read more.
3D concrete printing (3DCP) requires precise adjustments to parameters to ensure accurate and high-quality prints. However, despite technological advancements, manual intervention still plays a prominent role in this process, leading to errors and inconsistencies in the final printed part. To address this issue, machine learning vision models have been developed and utilized to analyze captured images and videos of the printing process, detecting defects and deviations. The data collected enable automatic adjustments to print settings, improving quality without the need for human intervention. This work first examines various techniques for real-time and offline corrections. It then introduces a specialized computer vision setup designed for real-time control in robotic 3DCP. Our main focus is on a specific aspect of machine learning (ML) within this system, called speed control, which regulates layer width by adjusting the robot motion speed or material flow rate. The proposed framework consists of three main elements: (1) a data acquisition and processing pipeline for extracting printing parameters and constructing a synthetic training dataset, (2) a real-time ML model for parameter optimization, and (3) a depth camera installed on a customized 3D-printed rotary mechanism for close-range monitoring of the printed layer. Full article
(This article belongs to the Special Issue Innovations in 3D Printing 3.0)
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9 pages, 2547 KiB  
Article
De Novo DNM1L Mutation in a Patient with Encephalopathy, Cardiomyopathy and Fatal Non-Epileptic Paroxysmal Refractory Vomiting
by Beatrice Berti, Daniela Verrigni, Alessia Nasca, Michela Di Nottia, Daniela Leone, Alessandra Torraco, Teresa Rizza, Emanuele Bellacchio, Andrea Legati, Concetta Palermo, Silvia Marchet, Costanza Lamperti, Antonio Novelli, Eugenio Maria Mercuri, Enrico Silvio Bertini, Marika Pane, Daniele Ghezzi and Rosalba Carrozzo
Int. J. Mol. Sci. 2024, 25(14), 7782; https://doi.org/10.3390/ijms25147782 - 16 Jul 2024
Viewed by 248
Abstract
Mitochondrial fission and fusion are vital dynamic processes for mitochondrial quality control and for the maintenance of cellular respiration; they also play an important role in the formation and maintenance of cells with high energy demand including cardiomyocytes and neurons. The DNM1L (dynamin-1 [...] Read more.
Mitochondrial fission and fusion are vital dynamic processes for mitochondrial quality control and for the maintenance of cellular respiration; they also play an important role in the formation and maintenance of cells with high energy demand including cardiomyocytes and neurons. The DNM1L (dynamin-1 like) gene encodes for the DRP1 protein, an evolutionary conserved member of the dynamin family that is responsible for the fission of mitochondria; it is ubiquitous but highly expressed in the developing neonatal heart. De novo heterozygous pathogenic variants in the DNM1L gene have been previously reported to be associated with neonatal or infantile-onset encephalopathy characterized by hypotonia, developmental delay and refractory epilepsy. However, cardiac involvement has been previously reported only in one case. Next-Generation Sequencing (NGS) was used to genetically assess a baby girl characterized by developmental delay with spastic–dystonic, tetraparesis and hypertrophic cardiomyopathy of the left ventricle. Histochemical analysis and spectrophotometric determination of electron transport chain were performed to characterize the muscle biopsy; moreover, the morphology of mitochondria and peroxisomes was evaluated in cultured fibroblasts as well. Herein, we expand the phenotype of DNM1L-related disorder, describing the case of a girl with a heterozygous mutation in DNM1L and affected by progressive infantile encephalopathy, with cardiomyopathy and fatal paroxysmal vomiting correlated with bulbar transitory abnormal T2 hyperintensities and diffusion-weighted imaging (DWI) restriction areas, but without epilepsy. In patients with DNM1L mutations, careful evaluation for cardiac involvement is recommended. Full article
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11 pages, 6455 KiB  
Article
Atmospheric Turbulence Phase Reconstruction via Deep Learning Wavefront Sensing
by Yutao Liu, Mingwei Zheng and Xingqi Wang
Sensors 2024, 24(14), 4604; https://doi.org/10.3390/s24144604 - 16 Jul 2024
Viewed by 231
Abstract
The fast and accurate reconstruction of the turbulence phase is crucial for compensating atmospheric disturbances in free-space coherent optical communication. Traditional methods suffer from slow convergence and inadequate phase reconstruction accuracy. This paper introduces a deep learning-based approach for atmospheric turbulence phase reconstruction, [...] Read more.
The fast and accurate reconstruction of the turbulence phase is crucial for compensating atmospheric disturbances in free-space coherent optical communication. Traditional methods suffer from slow convergence and inadequate phase reconstruction accuracy. This paper introduces a deep learning-based approach for atmospheric turbulence phase reconstruction, utilizing light intensity images affected by turbulence as the basis for feature extraction. The method employs extensive light intensity-phase samples across varying turbulence intensities for training, enabling phase reconstruction from light intensity images. The trained U-Net model reconstructs phases for strong, medium, and weak turbulence with an average processing time of 0.14 s. Simulation outcomes indicate an average loss function value of 0.00027 post-convergence, with a mean squared error of 0.0003 for individual turbulence reconstructions. Experimental validation yields a mean square error of 0.0007 for single turbulence reconstruction. The proposed method demonstrates rapid convergence, robust performance, and strong generalization, offering a novel solution for atmospheric disturbance correction in free-space coherent optical communication. Full article
(This article belongs to the Section Optical Sensors)
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