Acta Pharmacologica Sinica

Structure genomics of SARS-CoV-2 and its Omicron variant

Targeted degradation of membrane and extracellular proteins with LYTACs

Yu-yang Li
Yang Yang
Song-bo Xie

Review Article 05 August 2024

Featured

The correlation between mitochondria-associated endoplasmic reticulum membranes (MAMs) and Ca²⁺ transport in the pathogenesis of diseases

Wen-bin Zhao
Rui Sheng
Review Article08 Aug 2024
Foxp3 inhibitory peptide encapsulated in a novel CD25-targeted nanoliposome promotes efficient tumor regression in mice

Alejandro Serrano
Noelia Casares
MarÃa J. Garrido
ArticleOpen Access29 Jul 2024
A small molecule compound targeting hemagglutinin inhibits influenza A virus and exhibits broad-spectrum antiviral activity

Yin-yan Li
Guo-dong Liang
Jie Yang
Article10 Jul 2024
Luteolin-7-diglucuronide, a novel PTP1B inhibitor, ameliorates hepatic stellate cell activation and liver fibrosis in mice

Bi-xi Tang
Yong Zhang
Yi Zang
Article05 Aug 2024

Current issue

The regulation and function of Nrf2 signaling in ferroptosis-activated cancer therapy

Xin Jiang
Min Yu
Li-feng Feng
Review Article17 Jul 2024
Glial growth factor 2 treatment alleviates ischemia and reperfusion-damaged integrity of the blood-brain barrier through decreasing Mfsd2a/caveolin-1-mediated transcellular and Pdlim5/YAP/TAZ-mediated paracellular permeability

Xiao-ling Zhang
Wei-hong Du
Xin-chun Jin
Article20 Jun 2024
Single-dose methamphetamine administration impairs ORM retrieval in mice via excessive DA-mediated inhibition of PrL^Glu activity

Jian-chi Ma
Xiao-hang Che
Jing-yu Yang
Article24 Jun 2024
A new tau dephosphorylation-targeting chimera for the treatment of tauopathies

Jing-fen Su
Yue Xiao
Jian-zhi Wang
Article02 Jul 2024
Urolithin A promotes atherosclerotic plaque stability by limiting inflammation and hypercholesteremia in Apolipoprotein Eâdeficient mice

Meng-yun Xu
Jing-jing Xu
Suo-wen Xu
Article17 Jun 2024
In situ reprogramming of cardiac fibroblasts into cardiomyocytes in mouse heart with chemicals

Zi-yang Chen
Si-jia Ji
Xin Xie
Article18 Jun 2024

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Announcements

JOIN US | Deputy Director Position of SKLDR

State Key Laboratory of Drug Research (SKLDR), which was approved by Chinese Academy of Sciences under the unremitting efforts of reorganizing the state key laboratory system, is recruiting a Deputy Director. The candidate is expected to help SKLDR to continuously improve the academic influence and the ability to transform new drug achievements into real productivity.

Browse articles

How improvements in US FDA regulatory process and procedures led to the drug approval for first ever treatment of a common liver disease

Brian E. Harvey
Article07 Nov 2024
Smad transcription factors as mediators of 7 transmembrane G protein-coupled receptor signalling

Zheng-Jie Chia
Hirushi Kumarapperuma
Danielle Kamato
Review ArticleOpen Access06 Nov 2024
Dependence of NPPS creates a targetable vulnerability in RAS-mutant cancers

Rui-xue Xia
Pei-chen Zou
Hui-min Lei
ArticleOpen Access06 Nov 2024
Intestinal human carboxylesterase 2 (CES2) expression rescues drug metabolism and most metabolic syndrome phenotypes in global Ces2 cluster knockout mice

Yao-geng Wang
Chang-pei Gan
Alfred H. Schinkel
ArticleOpen Access04 Nov 2024
Luteolin ameliorates chronic stress-induced depressive-like behaviors in mice by promoting the Arginase-1⁺ microglial phenotype via a PPARÎ³-dependent mechanism

Nai-jun Yuan
Wen-jun Zhu
Jia-xu Chen
Article04 Nov 2024
Poria cocos: traditional uses, triterpenoid components and their renoprotective pharmacology

Zhi-yuan Guo
Xin Wu
Ying-yong Zhao
Review Article31 Oct 2024
VEGFD/VEGFR3 signaling contributes to the dysfunction of the astrocyte IL-3/microglia IL-3RÎ± cross-talk and drives neuroinflammation in mouse ischemic stroke

Shuai Wang
Yi Guo
Hui-ling Zhang
Article30 Oct 2024
Sequential activation of ERÎ±-AMPKÎ± signaling by the flavonoid baicalin down-regulates viral HNF-dependent HBV replication

Yi-jun Niu
Cheng-jie Xia
Xun-long Shi
ArticleOpen Access30 Oct 2024
Clozapine impaired glucose-stimulated insulin secretion partly by increasing plasma 5-HT levels due to the inhibition of OCT1-mediated hepatic 5-HT uptake in mice

Wen-han Wu
Hao Zhi
Li Liu
Article29 Oct 2024

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Science jobs

Assistant Professor of Molecular Metabolism

The Department of Molecular Metabolism (MET) at the Harvard Chan School invites applications for the level of assistant professor.

Boston, Massachusetts

Harvard T.H. Chan School of Public Health, Department of Nutrition
Recruitment of Overseas Outstanding Young Scholars

State Key Laboratory of Materials-Oriented Chemical Engineering in the field of materials-oriented chemical engineering.

Nanjing, Jiangsu, China

State Key Laboratory of Materials-Oriented Chemical Engineering, Nanjing Tech University
Faculty Positions at SUSTech School of Medicine

SUSTech School of Medicine offers equal opportunities and welcome applicants from the world with all ethnic backgrounds.

Shenzhen, Guangdong, China

Southern University of Science and Technology, School of Medicine
Al Medical Engineering at School of Biomedical Engineering

Tsinghua BME offers faculty positions in the emerging research direction of AI Medical Engineering

Beijing, China

Tsinghua University
Faculty Positions at the Center for Advanced Microbiome Research

Faculty Positions in Microbiome Research at the Center for Advanced Microbiome Research and Innovation, Institute for Genome Sciences, UM SOM

Baltimore, Maryland

Institute for Genome Sciences, University of Maryland School of Medicine

This journal is a member of and subscribes to the principles of the Committee on Publication Ethics.

Targeted degradation of membrane and extracellular proteins with LYTACs

Featured

The correlation between mitochondria-associated endoplasmic reticulum membranes (MAMs) and Ca²⁺ transport in the pathogenesis of diseases

Foxp3 inhibitory peptide encapsulated in a novel CD25-targeted nanoliposome promotes efficient tumor regression in mice

A small molecule compound targeting hemagglutinin inhibits influenza A virus and exhibits broad-spectrum antiviral activity

Luteolin-7-diglucuronide, a novel PTP1B inhibitor, ameliorates hepatic stellate cell activation and liver fibrosis in mice

Current issue

The regulation and function of Nrf2 signaling in ferroptosis-activated cancer therapy

Glial growth factor 2 treatment alleviates ischemia and reperfusion-damaged integrity of the blood-brain barrier through decreasing Mfsd2a/caveolin-1-mediated transcellular and Pdlim5/YAP/TAZ-mediated paracellular permeability

Single-dose methamphetamine administration impairs ORM retrieval in mice via excessive DA-mediated inhibition of PrL^Glu activity

A new tau dephosphorylation-targeting chimera for the treatment of tauopathies

Urolithin A promotes atherosclerotic plaque stability by limiting inflammation and hypercholesteremia in Apolipoprotein Eâdeficient mice

In situ reprogramming of cardiac fibroblasts into cardiomyocytes in mouse heart with chemicals

Announcements

JOIN US | Deputy Director Position of SKLDR

Browse articles

How improvements in US FDA regulatory process and procedures led to the drug approval for first ever treatment of a common liver disease

Smad transcription factors as mediators of 7 transmembrane G protein-coupled receptor signalling

Dependence of NPPS creates a targetable vulnerability in RAS-mutant cancers

Intestinal human carboxylesterase 2 (CES2) expression rescues drug metabolism and most metabolic syndrome phenotypes in global Ces2 cluster knockout mice

Luteolin ameliorates chronic stress-induced depressive-like behaviors in mice by promoting the Arginase-1⁺ microglial phenotype via a PPARÎ³-dependent mechanism

Poria cocos: traditional uses, triterpenoid components and their renoprotective pharmacology

VEGFD/VEGFR3 signaling contributes to the dysfunction of the astrocyte IL-3/microglia IL-3RÎ± cross-talk and drives neuroinflammation in mouse ischemic stroke

Sequential activation of ERÎ±-AMPKÎ± signaling by the flavonoid baicalin down-regulates viral HNF-dependent HBV replication

Clozapine impaired glucose-stimulated insulin secretion partly by increasing plasma 5-HT levels due to the inhibition of OCT1-mediated hepatic 5-HT uptake in mice

Trending - Altmetric

Science jobs

Assistant Professor of Molecular Metabolism

Recruitment of Overseas Outstanding Young Scholars

Faculty Positions at SUSTech School of Medicine

Al Medical Engineering at School of Biomedical Engineering

Faculty Positions at the Center for Advanced Microbiome Research

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Endothelial dysfunction in COVID-19: an overview of evidence, biomarkers, mechanisms and potential therapies

Nicotine and inflammatory neurological disorders

AlphaFold2 versus experimental structures: evaluation on G protein-coupled receptors

Smad transcription factors as mediators of 7 transmembrane G protein-coupled receptor signalling

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